Diabetes and Persistent Organic Pollutants

糖尿病和持久性有机污染物

• 批准号: 7921558
• 负责人: Mary Ellen Turyk
• 金额: $ 18.95万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921558
• 关键词: Adipose tissue; Age; Aging; Antibodies; Biological Markers; Body mass index; C-reactive protein; Chemicals; Confounding Factors (Epidemiology); Cross-Sectional Studies; Data; Development; Diabetes Mellitus; Diabetes prevention; Diagnosis; Dioxins; Disease; Endocrine; Environmental Exposure; Environmental Pollutants; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Ethers; Exclusion; Exposure to; Fishes; Future; Gender; General Population; Genetic; Glutamate Decarboxylase; Glycosylated hemoglobin A; Goals; Health Status; Incidence; Investigation; Knowledge; Length; Measurement; Measures; Mediator of activation protein; Metabolism; Modification; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Occupational Exposure; Participant; Persons; Pesticides; Polybrominated Biphenyls; Polychlorinated Biphenyls; Population; Prevalence; Prospective Studies; Research; Risk; Risk Factors; Role; Sampling; Serum; Sports; Testing; Time; Transferase; Triglycerides; Work; adiponectin; cohort; diabetes risk; dibenzo(1,4)dioxin; dichlorodiphenyltrichloroethane; environmental agent; environmental chemical; exposed human population; follow-up; high risk; insight; modifiable risk; pollutant; prospective; public health relevance

DESCRIPTION (provided by applicant): Diabetes is related to both genetic and environmental factors. While obesity and physical inactivity are dominant etiologic factors, exposure to environmental chemicals may also contribute to risk. Persistent organic pollutants (POPs) such as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (PBDEs) are detectable in most of the US population. Recently, general population exposures to POPs, such as dioxins, PCBs, and DDE, have been associated with type 2 diabetes in several cross sectional studies and PCBs were associated with diabetes in one prospective study. The proposed project will build upon 15 years of research observation of a POP-exposed, aging cohort of Great Lakes sport fish consumers, who are at higher risk of exposure to PCBs and related compounds. POPs were measured in 947 participants at various times between 1994 and 2005. Follow up of 471 participants shows a strong association of DDE with incident diabetes. The new study will expand data on confounding variables and extend follow up of the cohort for incident diabetes, increasing the number of incident cases and the power to detect effects of PBDEs and gender specific effects of DDE and PCBs; evaluating effect modification among multiple exposures and adiposity; and determining if the association of DDE and diabetes remains significant in participants with incident diabetes more than 10 years after exposure measurements. Associations of POPs with biomarkers of diabetes risk will be investigated by testing banked serum samples for adiponectin, C reactive protein, glutamic acid decarboxylase antibodies, and 3-glutamyl transferase. The proposed research allows for efficient follow up of important findings in a well defined cohort, and will provide insight into promising avenues for future epidemiologic and toxicologic investigations on the effect of environmental exposures on diabetes. It will be the first prospective diabetes study for DDE and PBDE exposure and will be the first study of to investigate biomarkers of diabetes risk and DDE exposure. Given the ubiquitous exposure of human populations to POPs and the increasing incidence of diabetes, investigations that further delineate the role of these potentially modifiable environmental agents are important for prevention of diabetes. PUBLIC HEALTH RELEVANCE: Project Narrative This investigation will study the effect of exposure to environmental pollutants on development of diabetes. The chemicals under study are polychlorinated biphenyls (PCBs), dioxins, polybrominated biphenyl ethers (PBDEs), and p,p'-diphenyldichloroethene (DDE), a metabolite of the pesticide DDT (dichlorodiphenyltrichloroethane). It is important to find out if exposure to persistent pollutants is related to the development of diabetes because most of the population is exposed to small amounts of these chemicals.

描述（申请人提供）：糖尿病与遗传和环境因素有关。虽然肥胖和缺乏身体活动是主要的致病因素，但接触环境化学品也可能导致风险。持久性有机污染物（POP），如二恶英，多氯联苯（PCBs），p，p '-二苯基二氯乙烯（DDE）和多溴联苯醚（PBDEs）在大多数美国人口中是可检测的。最近，一般人群暴露于持久性有机污染物，如二恶英，多氯联苯和DDE，已与2型糖尿病在几个横断面研究和多氯联苯与糖尿病在一个前瞻性研究。拟议的项目将建立在对接触持久性有机污染物的五大湖运动鱼类消费者老龄群体进行15年研究观察的基础上，这些消费者接触多氯联苯和相关化合物的风险较高。1994年至2005年期间，在不同时间对947名参与者进行了持久性有机污染物测量。对471名参与者的随访显示DDE与糖尿病事件有很强的关联。这项新的研究将扩大混杂变量的数据，并扩大糖尿病发病队列的随访，增加发病病例的数量和检测多溴联苯醚影响以及DDE和PCB的性别特异性影响的能力;评估多次暴露和肥胖之间的影响修正;并确定DDE和糖尿病的关联在暴露测量后超过10年的糖尿病事件参与者中是否仍然显著。将通过检测库存血清样本中的脂联素、C反应蛋白、谷氨酸脱羧酶抗体和3-谷氨酰转移酶来研究持久性有机污染物与糖尿病风险生物标志物的相关性。拟议的研究允许在一个明确定义的队列中有效跟踪重要发现，并将为未来环境暴露对糖尿病影响的流行病学和毒理学调查提供有前途的途径。这将是第一个关于DDE和PBDE暴露的前瞻性糖尿病研究，也将是第一个研究糖尿病风险和DDE暴露的生物标志物的研究。鉴于人类普遍暴露于持久性有机污染物，糖尿病发病率不断上升，因此开展调查，进一步确定这些可能改变的环境因子的作用，对于预防糖尿病十分重要。公共卫生关系：本研究将研究暴露于环境污染物对糖尿病发展的影响。正在研究的化学品是多氯联苯（PCB）、二恶英、多溴联苯醚（PBDEs）和p，p '-二苯基二氯乙烯（DDE），后者是杀虫剂滴滴涕（二氯二苯基三氯乙烷）的代谢物。重要的是要查明接触持久性污染物是否与糖尿病的发展有关，因为大多数人口接触少量这些化学品。

项目成果

Longitudinal biomonitoring for polybrominated diphenyl ethers (PBDEs) in residents of the Great Lakes basin.

• DOI: 10.1016/j.chemosphere.2010.07.037
• 发表时间: 2010-09
• 期刊: Chemosphere
• 影响因子: 8.8
• 作者: Turyk ME;Anderson HA;Steenport D;Buelow C;Imm P;Knobeloch L
• 通讯作者: Knobeloch L

Uterine leiomyomata in a cohort of Great Lakes sport fish consumers.

• DOI: 10.1016/j.envres.2011.01.006
• 发表时间: 2011-05
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Lambertino A;Turyk M;Anderson H;Freels S;Persky V
• 通讯作者: Persky V

Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers.

• DOI: 10.1016/j.envres.2015.03.037
• 发表时间: 2015-07
• 期刊: ENVIRONMENTAL RESEARCH
• 影响因子: 8.3
• 作者: Turyk, Mary;Fantuzzi, Giamila;Persky, Victoria;Freels, Sally;Lambertino, Anissa;Pini, Maria;Rhodes, Davina H.;Anderson, Henry A.
• 通讯作者: Anderson, Henry A.