Lanthanide Containing ZnS Nanoparticles

含有 ZnS 纳米粒子的镧系元素

基本信息

  • 批准号:
    7825382
  • 负责人:
  • 金额:
    $ 17.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-06-01 至 2012-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal describes a program to develop nanoparticles with advanced luminescence properties by combining zinc sulfide (ZnS) semiconductor nanoparticles and luminescent lanthanide cations so that the photophysical advantages of each are exploited. The aim is to use ZnS nanoparticles, with their large absorption cross section, to sensitize the lanthanide cations emission by an "antenna effect" and to provide a matrix that protects the lanthanides from nonradiative deactivation. ZnS is a desirable matrix because it is less toxic than the widely used CdSe nanocrystals, however the ZnS bandgap lies in the ultraviolet/blue spectral region, which has made them incompatible with biological imaging applications because of the strong interference between UV/blue photons and biological systems. However, the addition of lanthanide cations to the ZnS matrix causes the excitation energy to be released through the lanthanide cations as sharp emission bands in the visible and near infrared, determined by the nature of the lanthanide action. The lanthanide cations have sharp well defined emission bands that are insensitive to their environment (such as temperature, pH, pressure or biological environment) and allows for spectral discrimination from biological background (autofluorescence). Lanthanide cations also have longer luminescent lifetimes (micro- to milliseconds) than many other fluorescence emitters, allowing for temporal discrimination between the analyte signal and the background fluorescence. Chemical derivatization of the nanoparticle surface will be used to provide the biochemical selectivity for the nanocrystal probe and to make the material safe and soluble for the targeted biological applications. These materials will be tested in tissue and cell-based preparations and compared to commercially available probes for use in fluorescence microscopy applications. The toxicity of the nanocrystals will be evaluated using highly sensitive optical imaging methodologies for detecting cellular damage and death in primary cell culture models. PUBLIC HEALTH RELEVANCE: We will develop a novel family of luminescent nanoparticles that emit visible or near infrared light and are specifically designed to operate as fluorescent reporters in a broad range of "in vivo" and "in vitro" bioanalytical applications, including biological imaging. Ultimately, these nanoparticles will constitute a versatile luminescence platform whose optical properties will complement existing fluorophores, their signal being easily discriminated from the native fluorescence of biological systems.
描述(由申请人提供):该提案描述了通过将硫化锌(ZnS)半导体纳米颗粒和发光镧系元素阳离子组合以开发具有先进发光特性的纳米颗粒的计划,从而利用每种纳米颗粒的物理学优势。目的是使用ZnS纳米颗粒,其大的吸收截面,敏化镧系元素阳离子发射的“天线效应”,并提供一个矩阵,保护镧系元素从非辐射失活。ZnS是一种理想的基质,因为它比广泛使用的CdSe纳米晶体毒性更小,然而ZnS带隙位于紫外/蓝色光谱区域,这使得它们与生物成像应用不相容,因为UV/蓝色光子和生物系统之间的强烈干扰。然而,将镧系元素阳离子添加到ZnS基质中导致激发能通过镧系元素阳离子释放为可见光和近红外中的尖锐发射带,这由镧系元素作用的性质决定。镧系元素阳离子具有清晰明确的发射谱带,其对其环境(例如温度、pH、压力或生物环境)不敏感,并且允许从生物背景(自发荧光)进行光谱区分。镧系元素阳离子还具有比许多其他荧光发射体更长的发光寿命(微米至毫秒),允许分析物信号和背景荧光之间的时间区分。纳米颗粒表面的化学衍生化将用于为纳米晶体探针提供生化选择性,并使材料安全且可溶于目标生物应用。这些材料将在基于组织和细胞的制剂中进行测试,并与用于荧光显微镜应用的市售探针进行比较。纳米晶体的毒性将使用用于检测原代细胞培养模型中的细胞损伤和死亡的高灵敏度光学成像方法来评估。 公共卫生关系:我们将开发一种新型的发光纳米颗粒,发射可见光或近红外光,并专门设计为在广泛的“体内”和“体外”生物分析应用,包括生物成像中作为荧光报告。最终,这些纳米颗粒将构成一个通用的发光平台,其光学特性将补充现有的荧光团,它们的信号很容易从生物系统的天然荧光中区分出来。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Perfluorinated aromatic spacers for sensitizing europium(III) centers in dinuclear oligomers: better than the best by chemical design?
  • DOI:
    10.1002/anie.201205082
  • 发表时间:
    2012-11-05
  • 期刊:
  • 影响因子:
    16.6
  • 作者:
    Lemonnier, Jean-Francois;Babel, Lucille;Guenee, Laure;Mukherjee, Prasun;Waldeck, David H.;Eliseeva, Svetlana V.;Petoud, Stephane;Piguet, Claude
  • 通讯作者:
    Piguet, Claude
Lanthanide sensitization in II-VI semiconductor materials: a case study with terbium(III) and europium(III) in zinc sulfide nanoparticles.
  • DOI:
    10.1021/jp109786w
  • 发表时间:
    2011-04-28
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mukherjee P;Shade CM;Yingling AM;Lamont DN;Waldeck DH;Petoud S
  • 通讯作者:
    Petoud S
Optimizing sensitization processes in dinuclear luminescent lanthanide oligomers: selection of rigid aromatic spacers.
  • DOI:
    10.1021/ja206806t
  • 发表时间:
    2011-10-12
  • 期刊:
  • 影响因子:
    15
  • 作者:
    Lemonnier, Jean-Francois;Guenee, Laure;Beuchat, Cesar;Wesolowski, Tomasz A.;Mukherjee, Prasun;Waldeck, David H.;Gogick, Kristy A.;Petoud, Stephane;Piguet, Claude
  • 通讯作者:
    Piguet, Claude
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DAVID H WALDECK其他文献

DAVID H WALDECK的其他文献

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{{ truncateString('DAVID H WALDECK', 18)}}的其他基金

Development of Nanoscale Plasmonic Devices for Creation of a Next Generation Surf
开发纳米级等离激元器件以创造下一代冲浪
  • 批准号:
    8252113
  • 财政年份:
    2010
  • 资助金额:
    $ 17.8万
  • 项目类别:
Development of Nanoscale Plasmonic Devices for Creation of a Next Generation Surf
开发纳米级等离激元器件以创造下一代冲浪
  • 批准号:
    8071591
  • 财政年份:
    2010
  • 资助金额:
    $ 17.8万
  • 项目类别:
Development of Nanoscale Plasmonic Devices for Creation of a Next Generation Surf
开发纳米级等离激元器件以创造下一代冲浪
  • 批准号:
    7762447
  • 财政年份:
    2010
  • 资助金额:
    $ 17.8万
  • 项目类别:
Lanthanide Containing ZnS Nanoparticles
含有 ZnS 纳米粒子的镧系元素
  • 批准号:
    7573743
  • 财政年份:
    2009
  • 资助金额:
    $ 17.8万
  • 项目类别:

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