Genetics of MRSA Infection

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Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Recent advances in large‐scale DNA sequencing have the potential for rapid advances in correlating disease phenotypes with genotypes. Infectious disease research has long focused on the pathogen’s role in infection but less so on the impact of the host genotype. The current epidemic of Methicillin Resistant Staphylococcus aureus (MRSA) infection is a Grand Opportunity to apply new genetic methods to understanding this disease. There are multiple outcomes from MRSA infection, ranging from curable localized infection to devastating invasive infection. The project will study 500 subjects with MRSA infections by applying high throughput DNA sequencing to candidate genes involved in immune and other host responses to infection to correlate the outcome of infection with the host genotype. In addition, MRSA isolates from these same patients will be sequenced to determine if there are polymorphisms in the bacteria contributing to disease severity. The long‐range benefit of this information will be rapid prediction of infection outcome leading to rational therapeutic intervention.