Genetics of MRSA Infection

MRSA 感染的遗传学

• 批准号: 7945358
• 负责人: GEORGE M WEINSTOCK
• 金额: $ 100万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7945358
• 关键词: Abscess; Adult; Antibiotic Therapy; Arts; Bacteria; Bacterial DNA; Bacterial Genome; Bioinformatics; Biological; Candidate Disease Gene; Chicago; Child; Clinical; Communities; Consensus; DNA; DNA Resequencing; DNA Sequence; Data; Data Analyses; Detection; Development; Disease; Drainage procedure; Employee Strikes; Epidemic; Focal Infection; Genes; Genetic; Genetic Polymorphism; Genome; Genotype; Goals; Hospitals; Host Defense; Human; Immune; Immune response; Individual; Infection; Infectious Diseases Research; Inflammatory; Inflammatory Response; Life; Methodology; Methods; Morbidity - disease rate; Muscle; Mutation; Oligonucleotide Probes; Outcome; Patients; Phenotype; Pneumonia; Role; Sampling; Sepsis; Sequence Analysis; Skin; Soft Tissue Infections; Solutions; Subgroup; System; Texas; Text; Therapeutic Intervention; Universities; Validation; Variant; Virulence Factors; Washington; base; bone; candidate validation; clinical phenotype; clinical research site; defense response; disease phenotype; genome sequencing; medical schools; methicillin resistant Staphylococcus aureus; mortality; next generation; pathogen

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Recent advances in large‐scale DNA sequencing have the potential for rapid advances in correlating disease phenotypes with genotypes. Infectious disease research has long focused on the pathogen’s role in infection but less so on the impact of the host genotype. The current epidemic of Methicillin Resistant Staphylococcus aureus (MRSA) infection is a Grand Opportunity to apply new genetic methods to understanding this disease. There are multiple outcomes from MRSA infection, ranging from curable localized infection to devastating invasive infection. The project will study 500 subjects with MRSA infections by applying high throughput DNA sequencing to candidate genes involved in immune and other host responses to infection to correlate the outcome of infection with the host genotype. In addition, MRSA isolates from these same patients will be sequenced to determine if there are polymorphisms in the bacteria contributing to disease severity. The long‐range benefit of this information will be rapid prediction of infection outcome leading to rational therapeutic intervention.

在此输入文本，它是您的应用程序的新摘要信息。此部分不得超过30行文本。 大规模DNA测序的最新进展有可能在疾病表型与基因型别之间的关联方面取得快速进展。长期以来，传染病研究一直侧重于病原体在感染中的作用，而较少关注宿主基因的影响。目前甲氧西林耐药金黄色葡萄球菌(MRSA)感染的流行为应用新的遗传学方法了解这种疾病提供了一个巨大的机会。MRSA感染有多种后果，从可治愈的局部感染到毁灭性的侵袭性感染。该项目将研究500名MRSA感染的受试者，方法是对参与免疫和其他宿主对感染反应的候选基因进行高通量DNA测序，以将感染结果与宿主基因相关联。此外，还将对来自这些患者的MRSA分离株进行测序，以确定细菌中是否存在导致疾病严重程度的多态性。这些信息的长期好处将是快速预测感染结果，从而进行合理的治疗干预。