High-Throughput Sequencing Instrument for Stanford Cancer Center

描述(由申请人提供)：这项提案要求提供资金购买Illumina基因组分析仪II(GA II)，作为斯坦福大学推进生物医学研究的持续努力的一部分。拟议的高通量测序(HTS)仪器将放置在斯坦福大学医学院的功能基因组学设施(SFGF)中，并成为斯坦福癌症中心的HTS资源。由于SFGF是一个服务中心，美国国立卫生研究院资助的斯坦福大学的整个研究人员社区将能够使用GA II提供的技术。该设施目前利用微阵列技术为基因组学和蛋白质组研究提供专业知识、支持和服务。随着许多研究人员目前将HTS作为功能基因组研究的黄金标准，关键是要有一个共享的资源，这样才能继续进行这里所追求的开创性研究。GA II的HTS能力将使美国国立卫生研究院资助的斯坦福大学的研究人员能够进一步了解我们的遗传密码如何影响人类健康和疾病。与公共卫生相关：所要求的高通量测序(HTS)仪器将用于监测和调查细胞利用的生物分子。了解这些分子的功能将使我们更好地了解它们在人类健康和疾病中的作用。

DESCRIPTION (provided by applicant): This proposal requests funds to purchase an Illumina Genome Analyzer II (GA II) as part of ongoing efforts to advance biomedical research at Stanford University. The proposed High-Throughput Sequencing (HTS) instrument will be placed in the Stanford Functional Genomics Facility (SFGF) within the School of Medicine and be a HTS resource for the Stanford Cancer Center. Since SFGF is a service center, the entire community of NIH funded researchers at Stanford will have access to the technology provide by the GA II. The facility presently offers expertise, support, and services for genomics and proteomics research utilizing microarray technologies. As many investigators are currently turning to HTS as the gold standard for functional genomics studies, it is critical that a shared resource be available so that the pioneering research pursued here continues. The HTS capabilities of the GA II will give NIH funded researchers at Stanford University the ability to further understand how our genetic code affects human health and disease. PUBLIC HEALTH RELEVANCE: The requested high-throughput sequencing (HTS) instrument will be used to monitor and investigate biological molecules utilized by the cell. Knowledge of how these molecules function will give us a better understanding of their role in human health and disease.