High-Throughput Sequencing Instrument for Stanford Cancer Center

斯坦福癌症中心的高通量测序仪器

• 批准号: 7595509
• 负责人: PATRICK O. BROWN
• 金额: $ 50万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-19 至 2010-04-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595509
• 关键词: Affect; Biological; Biomedical Research; Cancer Center; Cells; Communities; Disease; Funding; Genetic Code; Genome; Genomics; Gold; Health; Human; Knowledge; Microarray Analysis; Monitor; Proteomics; Request for Proposals; Research; Research Personnel; Resource Sharing; Resources; Role; Services; Technology; United States National Institutes of Health; Universities; functional genomics; instrument; medical schools; public health relevance

DESCRIPTION (provided by applicant): This proposal requests funds to purchase an Illumina Genome Analyzer II (GA II) as part of ongoing efforts to advance biomedical research at Stanford University. The proposed High-Throughput Sequencing (HTS) instrument will be placed in the Stanford Functional Genomics Facility (SFGF) within the School of Medicine and be a HTS resource for the Stanford Cancer Center. Since SFGF is a service center, the entire community of NIH funded researchers at Stanford will have access to the technology provide by the GA II. The facility presently offers expertise, support, and services for genomics and proteomics research utilizing microarray technologies. As many investigators are currently turning to HTS as the gold standard for functional genomics studies, it is critical that a shared resource be available so that the pioneering research pursued here continues. The HTS capabilities of the GA II will give NIH funded researchers at Stanford University the ability to further understand how our genetic code affects human health and disease. PUBLIC HEALTH RELEVANCE: The requested high-throughput sequencing (HTS) instrument will be used to monitor and investigate biological molecules utilized by the cell. Knowledge of how these molecules function will give us a better understanding of their role in human health and disease.

描述（由申请人提供）：该提案请求资金购买 Illumina 基因组分析仪 II (GA II)，作为斯坦福大学持续推进生物医学研究的一部分。拟议的高通量测序 (HTS) 仪器将放置在医学院内的斯坦福功能基因组学设施 (SFGF) 中，并成为斯坦福癌症中心的 HTS 资源。由于 SFGF 是一个服务中心，因此 NIH 资助的斯坦福大学研究人员的整个社区都可以使用 GA II 提供的技术。该设施目前为利用微阵列技术的基因组学和蛋白质组学研究提供专业知识、支持和服务。由于许多研究人员目前正在将 HTS 作为功能基因组学研究的黄金标准，因此共享资源至关重要，以便继续进行开创性研究。 GA II 的 HTS 功能将使 NIH 资助的斯坦福大学研究人员能够进一步了解我们的遗传密码如何影响人类健康和疾病。 公共健康相关性：所需的高通量测序（HTS）仪器将用于监测和研究细胞利用的生物分子。了解这些分子如何发挥作用将使我们更好地了解它们在人类健康和疾病中的作用。