ULTRASOUND SYSTEM FOR CARDIOVASCULAR PHENOTYPE STUDIES IN HUMANS

用于人类心血管表型研究的超声系统

• 批准号: 7594861
• 负责人: Victor G. Davila-Roman
• 金额: $ 23.66万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7594861
• 关键词: Age; Aortic Valve Stenosis; Applications Grants; Area; Arts; Blood Vessels; Body Weight decreased; Cardiac; Cardiovascular Diseases; Cardiovascular system; Clinical Medicine; Clinical Research; Communities; Deep Vein Thrombosis; Diagnosis; Discipline; Equipment; Evaluation; Funding; Future; Genotype; Goals; Grant; Heart Diseases; Heart Valves; Housing; Human; Insulin-Dependent Diabetes Mellitus; Laboratories; Metabolic syndrome; Methods; Mission; Morbidity - disease rate; Obesity; Phenotype; Physicians; Play; Postmenopause; Postoperative Period; Prevention; Research; Research Activity; Research Personnel; Role; Scientist; Sickle Cell Anemia; Structure; System; Time; Tissues; Ultrasonics; Ultrasonography; United States; United States National Institutes of Health; Universities; Ventricular; Washington; Woman; cardiovascular imaging; heart metabolism; hypertensive heart disease; instrument; instrumentation; member; mortality; multidisciplinary; novel; novel strategies; programs; public health relevance; research study; success; translational study

DESCRIPTION (provided by applicant): This is the first resubmission of a Shared Instrumentation Grant (SIG) proposal requesting a state-of-the art GE Vivid 7 Ultrasound System, which will be used for exquisite cardiovascular phenotyping of humans for clinical research studies sponsored by the NIH and other organizations at Washington University. The requested system will be housed and operated in the Cardiovascular Imaging and Clinical Research Core Laboratory (CIRCL) located in the Center for Clinical Studies at Washington University. This dedicated ultrasound system will replace an existing ultrasound system which was purchased through the SIG mechanism in May 2000, and will be 9+ years by the time it is replaced through the current proposal. The current ultrasound system has been the workhorse of CIRCL, where the number of cardiac and vascular ultrasound studies has increased steadily since its original acquisition. Two major issues justify replacement: 1) the system has been malfunctioning for a number of years, thus creating difficulties in serving the current NIH-sponsored user group and 2) new technological advances requested by the user group justify the acquisition of a more modern system. The requested system will serve a user group composed primarily of 16 NIH-funded investigators at WU, representing a diverse range of disciplines, divisions, and departments. Each member of the user group has successfully used the present system, and a significant need for this system has been demonstrated during the past 9 years. The requested shared instrument will continue to have a major impact on the success of current and future NIH-supported research activities of the User Group and the clinical research community at Washington University. The requested system will be maintained and supervised by a Technical Director with administrative and scientific oversight by the CIRCL Director and PI for the requested instrument. This state-of-the-art cardiovascular ultrasound imaging system will continue to promote the success of the user group research programs and facilitate multidisciplinary efforts aimed at the characterization of cardiac and ventricular structure and function for translational studies in clinical medicine. The requested ultrasound system is critical for clinical research studies targeting major research areas, including: 1) Phenotype-genotype correlations in hypertensive heart disease; 2) Cardiac metabolism, structure and systolic/diastolic function in aging, T1DM, and in postmenopausal women; 3) Cardiac/vascular function in obesity and weight loss; 4) Vascular function in metabolic syndrome and regression with novel pharmacologic agents; 5) Cardiac/vascular function in HIV-AIDS; 6) Vascular structure-function and phenotype-genotype correlations in metabolic syndrome; 7)Cardiac and valve function in aortic stenosis and regression with novel pharmacologic agents; 8) Ultrasonic tissue characterization; 9) Cardiac function in Sickle Cell disease; 10) Novel strategies for prevention of postoperative deep venous thrombosis. Acquisition of the new ultrasound system will provide immediate benefit to the user group in accomplishing the scientific goals of their NIH funded projects. PUBLIC HEALTH RELEVANCE: Cardiovascular disease is the major cause of morbidity and mortality in the United States. Our mission as NIH- sponsored academic physician-scientists is to develop new methods for diagnosis and treatment of cardiovascular disease. The requested state-of-the-art ultrasound imaging equipment will continue to play a critical role in the evaluation of subjects with diseases of the heart and blood vessels for NIH-sponsored clinical research studies.

描述（由申请人提供）：这是共享仪器资助（SIG）提案的首次重新提交，该提案要求提供最先进的GE Vivid 7超声系统，该系统将用于由NIH和华盛顿大学的其他组织申办的临床研究中的人体精密心血管表型分析。所申请的系统将在位于华盛顿大学临床研究中心的心血管成像和临床研究核心实验室（CIRCL）中进行存放和操作。这一专用超声波系统将取代2000年5月通过SIG机制购买的现有超声波系统，到通过目前的提案取代时，该系统将使用9年以上。目前的超声系统一直是CIRCL的主力，自最初收购以来，心脏和血管超声研究的数量稳步增加。有两个主要问题需要更换：1）该系统多年来一直出现故障，因此难以为当前NIH赞助的用户群提供服务; 2）用户群要求的新技术进步需要购买更现代化的系统。所要求的系统将服务于一个主要由16个NIH资助的研究人员组成的用户组，代表了不同的学科，部门和部门。用户组的每一个成员都成功地使用了本系统，在过去9年中，对本系统的需求量很大。所请求的共享工具将继续对用户组和华盛顿大学临床研究社区当前和未来NIH支持的研究活动的成功产生重大影响。所要求的系统将由技术总监维护和监督，CIRCL总监和PI将对所要求的仪器进行行政和科学监督。这种最先进的心血管超声成像系统将继续促进用户组研究计划的成功，并促进旨在表征心脏和心室结构和功能的多学科努力，用于临床医学的转化研究。所要求的超声系统对于针对主要研究领域的临床研究至关重要，包括：1）高血压性心脏病中的表型-基因型相关性; 2）老年、T1 DM和绝经后女性中的心脏代谢、结构和收缩/舒张功能; 3）肥胖和体重减轻中的心脏/血管功能; 4）代谢综合征中的血管功能和新型药物的消退; 5）HIV-AIDS患者的心脏/血管功能; 6）代谢综合征患者的血管结构-功能和表型-基因型相关性; 7）主动脉瓣狭窄患者的心脏和瓣膜功能以及新型药物治疗后的消退; 8）超声组织表征; 9）镰状细胞病患者的心脏功能; 10）预防术后深静脉血栓形成的新策略。购买新的超声系统将为用户组提供直接的好处，以实现其NIH资助项目的科学目标。 公共卫生相关性：心血管疾病是美国发病率和死亡率的主要原因。我们的使命作为美国国立卫生研究院赞助的学术医生，科学家是开发新的方法，诊断和治疗心血管疾病。所要求的最先进的超声成像设备将继续在NIH申办的临床研究的心脏和血管疾病受试者评价中发挥关键作用。