Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru

项目摘要 MPIs：de las Fuentes，丽莎; Davila-Roman，维克托G.; Málaga，German; Hartinger，Stella D43项目名称：“研究培训：秘鲁的慢性非传染性心血管疾病和合并症” 项目开始/结束：2021年9月1日-2026年8月31日 慢性心血管疾病（CVD）是全球和秘鲁M&M的主要原因。除了有 通常的心血管疾病危险因素，社会因素，如社会经济地位低，环境暴露进一步 造成慢性CVD负担。在非传染性疾病中， 由于认识率低，治疗和控制是一个重要的卫生保健差距， 秘鲁的CVD负担。D43培训补助金的申请代表了美国 调查人员（圣路易斯的华盛顿大学和巴尔的摩的约翰霍普金斯大学）和 秘鲁研究人员（利马的秘鲁卡耶塔诺埃雷迪亚大学， Altiplano de普诺，AB PRISMA in Lima and普诺）. D43培训计划将利用现有的研究 在秘鲁，教科文组织正在实施一些项目和基础设施，以培训秘鲁科学家和慢性非传染性疾病/心血管疾病方面的卫生专业人员。 我们的团队已经成功地获得了赠款支持（即，美国国立卫生研究院，盖茨基金会）;然而，有限的 许多秘鲁研究人员进行和领导NCD/CVD研究是一个重大障碍， 实施有效和可持续的NCD/CVD研究计划。拟议的培训方案将 在五年内为14名学员提供支持（学费、津贴、研究资金）：8名硕士、4名博士和2名 博士后秘鲁学员和/或初级教师。这个结构化计划的目标是发展 学员在慢性心血管疾病，中风，实施科学和环境领域的研究生涯 接触;由国际知名的多学科教师提供指导和支持 专业知识;并提供职业发展和参与研究项目的机会。的 该计划将提供密集的培训机会，并在一系列科学学科的能力建设， 与实现研究独立性相关的技能。该计划的长期目标是建立一个可持续的 和合作研究培训基础设施，以培养秘鲁研究科学家， 执行干预措施，解决未满足的医疗保健需求，包括翻译基于证据的 在秘鲁，采取干预措施，执行和传播有效的政策，以改善公共卫生。 此应用程序响应PAR-18-901的合作机构，包括NHLBI（HTN/CVD），Fogarty 国际中心（全球健康和LMIC），国家老龄化研究所（NCD，包括CVD/HTN），国家 神经系统疾病和中风研究所（中风）和国立环境健康科学研究所 （环境暴露是非传染性疾病/心血管疾病的风险因素）。D43培训计划的最终目标是 （一）为优秀的初级调查员提供所需的专业知识，以解决具有挑战性的问题。 秘鲁慢性非传染性疾病/心血管疾病负担带来的问题; 2）完成 从美国到秘鲁的MPI，教师和机构的计划管理和领导，由D43年5。

PROJECT SUMMARY MPIs: de las Fuentes, Lisa; Davila-Roman, Victor G.; Málaga, German; Hartinger, Stella D43 Project Title: “Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru” Project start / end: 9/1/2021-8/31/2026 Chronic cardiovascular disease (CVD) is the leading cause of M&M worldwide and in Peru. In addition to the usual CVD risk factors, social factors such a low socioeconomic status and environmental exposure further contribute to chronic CVD burden. Among non-communicable diseases (NCDs), high prevalence of hypertension with low rates of awareness, treatment and control represent an important health care gap that contributes to CVD burden in Peru. This application for D43 Training Grant represents a collaboration between US investigators (Washington University in St. Louis and Johns Hopkins University in Baltimore) and Peruvian investigators (Universidad Peruana Cayetano Heredia in Lima, Universidad Nacional del Altiplano de Puno, AB PRISMA in Lima and Puno). The D43 training program will leverage existing research projects and infrastructure in Peru to train Peruvian scientists and health professionals in chronic NCDs/CVD. Our group has been successful in securing grant support (i.e., NIH, Gates Foundation); however, the limited number of Peruvian investigators conducting and leading NCD/CVD studies represents a significant barrier to implementing an effective and sustainable NCD/CVD research program. The proposed training program will provide support (tuition, stipend, research funds) for 14 trainees over five years: 8 master’s, 4 PhD, and 2 postdoctoral Peruvian trainees and/or junior faculty. The objectives of this structured program are to develop the research careers of trainees in the areas of chronic CVD, stroke, implementation science, and environmental exposure; to provide mentoring and support by an internationally renowned faculty with multidisciplinary expertise; and to provide opportunities for career advancement and engagement in research projects. The program will provide intensive training opportunities and build capacity in a range of scientific disciplines and skills relevant to achieving research independence. The long-term goal of this program is to build a sustainable and collaborative research-training infrastructure to develop Peruvian research scientists capable of designing and executing interventions addressing unmet healthcare needs, including the translation of evidence-based interventions and the implementation and dissemination of effective policies to improve public health in Peru. This application is responsive to partnering institutions of PAR-18-901 including the NHLBI (HTN/CVD), Fogarty International Center (global health and LMIC), National Institute of Aging (NCDs including CVD/HTN), National Institute of Neurological Disorders and Stroke (stroke), and National Institutes of Environmental Health Sciences (environmental exposure as risk factors for NCDs/CVD). The ultimate goals of this D43 training program are twofold: 1) to equip outstanding junior investigators with the necessary expertise to solve challenging problems presented by the burden of chronic NCDs/CVD in Peru; and 2) to complete a full transition of program administration and leadership from the US to Peruvian MPIs, faculty, and institutions by D43 Year 5.