Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru

研究培训：秘鲁的慢性非传染性心血管疾病和合并症

• 批准号: 10680600
• 负责人: Victor G. Davila-Roman
• 金额: $ 24.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10680600
• 关键词: Address; Area; Awareness; Baltimore; Cardiovascular Diseases; Career Mobility; Chronic; Collaborations; Discipline; Disease; Dissemination and Implementation; Doctor of Philosophy; Environmental Exposure; Evidence based intervention; Faculty; Fogarty International Center; Foundations; Funding; German population; Goals; Grant; Health Professional; Healthcare; High Prevalence; Hypertension; Institution; International; Intervention; Leadership; Mentors; National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Peru; Peruvian; Policies; Postdoctoral Fellow; Public Health; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Risk Factors; Scientist; Secure; Stroke; Structure; Training; Training Programs; Training and Infrastructure; Translations; United States National Institutes of Health; Universities; Washington; burden of illness; cardiovascular disorder risk; career; comorbidity; design; global health; implementation science; improved; low and middle-income countries; low socioeconomic status; multidisciplinary; programs; skills; social factors; training opportunity

PROJECT SUMMARY MPIs: de las Fuentes, Lisa; Davila-Roman, Victor G.; Málaga, German; Hartinger, Stella D43 Project Title: “Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru” Project start / end: 9/1/2021-8/31/2026 Chronic cardiovascular disease (CVD) is the leading cause of M&M worldwide and in Peru. In addition to the usual CVD risk factors, social factors such a low socioeconomic status and environmental exposure further contribute to chronic CVD burden. Among non-communicable diseases (NCDs), high prevalence of hypertension with low rates of awareness, treatment and control represent an important health care gap that contributes to CVD burden in Peru. This application for D43 Training Grant represents a collaboration between US investigators (Washington University in St. Louis and Johns Hopkins University in Baltimore) and Peruvian investigators (Universidad Peruana Cayetano Heredia in Lima, Universidad Nacional del Altiplano de Puno, AB PRISMA in Lima and Puno). The D43 training program will leverage existing research projects and infrastructure in Peru to train Peruvian scientists and health professionals in chronic NCDs/CVD. Our group has been successful in securing grant support (i.e., NIH, Gates Foundation); however, the limited number of Peruvian investigators conducting and leading NCD/CVD studies represents a significant barrier to implementing an effective and sustainable NCD/CVD research program. The proposed training program will provide support (tuition, stipend, research funds) for 14 trainees over five years: 8 master’s, 4 PhD, and 2 postdoctoral Peruvian trainees and/or junior faculty. The objectives of this structured program are to develop the research careers of trainees in the areas of chronic CVD, stroke, implementation science, and environmental exposure; to provide mentoring and support by an internationally renowned faculty with multidisciplinary expertise; and to provide opportunities for career advancement and engagement in research projects. The program will provide intensive training opportunities and build capacity in a range of scientific disciplines and skills relevant to achieving research independence. The long-term goal of this program is to build a sustainable and collaborative research-training infrastructure to develop Peruvian research scientists capable of designing and executing interventions addressing unmet healthcare needs, including the translation of evidence-based interventions and the implementation and dissemination of effective policies to improve public health in Peru. This application is responsive to partnering institutions of PAR-18-901 including the NHLBI (HTN/CVD), Fogarty International Center (global health and LMIC), National Institute of Aging (NCDs including CVD/HTN), National Institute of Neurological Disorders and Stroke (stroke), and National Institutes of Environmental Health Sciences (environmental exposure as risk factors for NCDs/CVD). The ultimate goals of this D43 training program are twofold: 1) to equip outstanding junior investigators with the necessary expertise to solve challenging problems presented by the burden of chronic NCDs/CVD in Peru; and 2) to complete a full transition of program administration and leadership from the US to Peruvian MPIs, faculty, and institutions by D43 Year 5.

项目概要 MPI：de las Fuentes、Lisa；达维拉-罗曼，维克多·G.；马拉加，德语；斯特拉·哈廷格 D43 项目名称：“研究培训：秘鲁的慢性非传染性心血管疾病和合并症” 项目开始/结束：9/1/2021-8/31/2026 慢性心血管疾病 (CVD) 是全世界和秘鲁 M&M 的主要原因。除了 通常的CVD危险因素、社会经济地位低等社会因素和环境暴露进一步 造成慢性CVD负担。在非传染性疾病（NCD）中，高血压患病率较高 由于认识率低，治疗和控制是一个重要的医疗保健缺口，导致 秘鲁的CVD负担。此 D43 培训补助金申请代表了美国与美国之间的合作 研究人员（圣路易斯华盛顿大学和巴尔的摩约翰霍普金斯大学）和 秘鲁调查人员（利马秘鲁卡耶塔诺埃雷迪亚大学、国立大学） Altiplano de Puno，利马和普诺的 AB PRISMA）。 D43 培训计划将利用现有研究 秘鲁的项目和基础设施，旨在培训秘鲁科学家和卫生专业人员处理慢性非传染性疾病/心血管疾病。 我们的团队已成功获得拨款支持（即 NIH、盖茨基金会）；然而，有限的 进行和领导非传染性疾病/心血管疾病研究的秘鲁研究人员数量是一个重大障碍 实施有效且可持续的非传染性疾病/心血管疾病研究计划。拟议的培训计划将 五年内为 14 名学员提供支持（学费、津贴、研究经费）：8 名硕士、4 名博士和 2 名 秘鲁博士后实习生和/或初级教师。该结构化计划的目标是开发 学员在慢性心血管疾病、中风、实施科学和环境领域的研究生涯 接触;由国际知名多学科教师提供指导和支持 专业知识;并提供职业发展和参与研究项目的机会。这 该计划将提供强化培训机会并建设一系列科学学科和领域的能力 与实现研究独立相关的技能。该计划的长期目标是建立一个可持续发展的 和合作研究培训基础设施，以培养具有设计能力的秘鲁研究科学家 并执行干预措施来解决未满足的医疗保健需求，包括翻译基于证据的 干预措施以及实施和传播有效政策以改善秘鲁的公共卫生。 此应用程序响应 PAR-18-901 的合作机构，包括 NHLBI (HTN/CVD)、Fogarty 国际中心（全球健康和 LMIC）、国家老龄化研究所（非传染性疾病，包括 CVD/HTN）、国家 神经疾病和中风研究所和美国国立环境健康科学研究所 （环境暴露是非传染性疾病/心血管疾病的危险因素）。此 D43 培训计划的最终目标是 双重：1）为优秀的初级研究者提供必要的专业知识来解决具有挑战性的问题 秘鲁慢性非传染性疾病/心血管疾病负担带来的问题； 2) 完成完整的过渡 D43 5 年级之前，美国向秘鲁 MPI、教师和机构提供项目管理和领导。