Auditory Processing and Memory for Complex Signals

复杂信号的听觉处理和记忆

• 批准号: 7901186
• 负责人: DAVID S VICARIO
• 金额: $ 14.78万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-14 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7901186
• 关键词: Acoustic Stimulation; Acoustics; Acute; Adult; Affect; Animals; Auditory; Auditory area; Back; Behavior; Biological Models; Birds; Brain; Chronic; Communication; Complex; Development; Discrimination; Electrodes; Expectancy; Exposure to; Finches; Human; Immediate-Early Genes; Individual; Infusion procedures; Injection of therapeutic agent; Knowledge; Language; Learning; Lesion; Light; Link; Medial; Memory; Methods; Modeling; Molecular Biology; Neurobiology; Neuronal Plasticity; Neurons; Pattern; Physiological; Physiology; Play; Preparation; Process; Production; Property; Prosencephalon; Protein Synthesis Inhibitors; Role; Sensory; Signal Transduction; Songbirds; Speech; Speech Perception; Speech Sound; Stereotyping; Stimulus; System; Taxon; Testing; Time; Work; auditory stimulus; awake; base; bird song; long term memory; male; memory process; memory recognition; neurophysiology; novel; relating to nervous system; response; social communication; sound; speech processing; stimulus interval; vocalization; zebra finch

DESCRIPTION (provided by applicant): The power of spoken language in communication is one of the defining adaptations of the human species, and it depends on the rapid production and perception of speech signals. Songbirds are the most easily studied of the few animal taxa that learn to produce vocal signals for social communication as humans do. Among songbirds, our knowledge of the zebra finch is most advanced. This application proposes to use the properties of auditory neurons in the songbird forebrain to investigate basic neural processes that serve discrimination and memory for auditory communication signals. Young male zebra finches learn their vocalizations from adult tutors through a process of imitation that resembles human speech acquisition. These vocalizations become stereotyped in adulthood and are unique to each individual, providing rich material for quantitative study of the brain processes that serve this natural communication system. Using neurophysiological recording in a forebrain auditory area, the caudo-medial nidopallium (NCM), the P.I. has demonstrated a neuronal form of recognition memory that lasts longer for conspecific than for heterospecific vocal sounds. These long-lasting memories discriminate the unique vocalizations of individual conspecifics, suggesting that NCM plays a special role in processing vocal signals. The significant acoustic and temporal features that distinguish sounds for NCM neurons can be assessed because, in this preparation, repeated presentation of a novel sound results in rapid, quantifiable decreases of the sensory response. When a different sound is presented, the response returns to its initial high level. This is a form of stimulus specific adaptation, reminiscent of similar processes described for the mammalian auditory cortex. The P.I. now proposes to record from NCM in awake zebra finches with advanced physiological methods, including acute and chronic multi-electrode recording, to determine 1) the detailed changes in neural response pattern that accompany memorization of a specific sound signal; 2) the temporal rules that govern the neural processing of more complex sounds composed of syllable sequences, as occurs in song; and 3) the way in which this auditory recognition and memory system is engaged during real-time interaction with conspecifics. The results will not only provide a quantitative description of auditory processing for behaviorally relevant signals in songbirds, but will also shed light on neural processes that link rapid sound sequences into recognizable auditory objects. This is a basic step in decoding speech, as well as song, so these studies may provide useful models for normal and pathological speech processing in humans.

描述（由申请人提供）：口语在交流中的力量是人类物种的定义适应性之一，它依赖于语音信号的快速产生和感知。在为数不多的像人类一样学会发出声音信号进行社会交流的动物类群中，鸣禽是最容易研究的。在鸣禽中，我们对斑胸草雀的了解是最先进的。该应用程序提出利用鸣禽前脑听觉神经元的特性来研究为听觉通信信号提供识别和记忆的基本神经过程。年轻的雄性斑胸草雀通过模仿类似人类语言习得的过程，从成年导师那里学习发声。这些声音在成年后变得定型，对每个人来说都是独一无二的，为定量研究服务于这种自然交流系统的大脑过程提供了丰富的材料。通过对前脑听觉区，即尾内侧乳头（NCM）的神经生理记录，P.I.证明了一种神经元形式的识别记忆，这种记忆对同种声音的持续时间比对异种声音的持续时间更长。这些持久的记忆区分了个体同类的独特发声，表明NCM在处理声音信号中起着特殊的作用。可以评估NCM神经元区分声音的重要声学和时间特征，因为在这种准备中，重复呈现新声音会导致感觉反应的快速，可量化的减少。当出现不同的声音时，响应会恢复到初始的高电平。这是刺激特异性适应的一种形式，让人想起哺乳动物听觉皮层的类似过程。P.I.现在建议用先进的生理学方法记录清醒的斑胸草雀的NCM，包括急性和慢性多电极记录，以确定1)伴随特定声音信号记忆的神经反应模式的详细变化；2)控制由音节序列组成的更复杂声音的神经处理的时间规则，如歌曲；3)这种听觉识别和记忆系统在与同种物的实时交互中是如何参与的。研究结果不仅可以定量描述鸣禽行为相关信号的听觉处理过程，还可以揭示将快速声音序列与可识别的听觉对象联系起来的神经过程。这是解码语音和歌曲的基本步骤，因此这些研究可能为人类正常和病理语音处理提供有用的模型。