Pediatric HIV Treatment Strategies

儿童艾滋病毒治疗策略

基本信息

项目摘要

Worldwide, there are over one million children with HIV infection. 41At year-end 2000, the Thai Ministry of Public Health (MOPH) reported 20,052 and 2, 332 cases of children living with HIV and AIDS respectively, and 4,185 newly infected childrenC-The use of highly active antiretroviral therapy (HAART) has resulted in a significant reduction of morbidity and mortality among adults and children with HIV infection. 4344Nevertheless, few children have access to treatment and care for HIV disease, and less than 1% of children are on effective ARV therapy. Applicability of this study to both resource-rich and resource-limited settin.qs In resource-limited countries such as Thailand where ARV treatment for HIV-infected children according to international and national guidelines is not affordable, mechanisms for selecting groups of children to receive ARV treatment are needed. In resource-rich countries where the majority of children have access to care, the initiation of ARV therapy, if sooner than needed, can result in unnecessary morbidity. Once begun on ARV therapy, children are committed to life-long treatment. The use of ARV therapy can be associated with significant morbidity, namely toxicity and development of virological resistance. Lipodystrophy, dyslipidaemia and diabetes mellitus are examples of side effects that can result 45 4647 in poor health and quality of life. Lactic acidosis and mitochondrial toxicity are potentially life-threatening side effects 4649Successful treatment with ARV in children requires high-level compliance, which is not an easy task, and can be stressful for families and the children themselves.so As there is currently no cure for HIV infection, a balance between treating the disease and maintaining good health and quality of life must be weighed carefully. We believe that for both resource-rich and resource-limited settings, an evaluation of the appropriate time of initiation of ARV therapy is needed. The treatment strategy of deferred ARV therapy must be evaluated.
全世界有100多万儿童感染艾滋病毒。41. 2000年底,泰国公共卫生部报告了20,052例和2,332例分别感染艾滋病毒和艾滋病的儿童,以及4,185名新感染的儿童。4344然而,很少有儿童能够获得艾滋病的治疗和护理,只有不到1%的儿童在接受有效的抗逆转录病毒治疗。 本研究对资源丰富和资源有限环境的适用性 在泰国等资源有限的国家,无法负担根据国际和国家准则为感染艾滋病毒的儿童提供抗逆转录病毒治疗的费用,因此需要建立机制,选择接受抗逆转录病毒治疗的儿童群体。 在资源丰富的国家,大多数儿童都能得到护理,如果过早开始抗逆转录病毒治疗,可能导致不必要的发病。儿童一旦开始接受抗逆转录病毒治疗,就必须终生接受治疗。抗逆转录病毒治疗的使用可能与严重的发病率,即毒性和病毒耐药性的发展有关。脂肪代谢障碍、血脂异常和糖尿病是可能导致的副作用的例子 454647健康状况不佳,生活质量不高。乳酸酸中毒和线粒体毒性是潜在的危及生命的副作用4649ARV在儿童中的成功治疗需要高水平的依从性,这不是一件容易的事情,并且可能对家庭和儿童造成压力themselves.so由于目前没有治愈艾滋病毒感染的方法,必须仔细权衡治疗疾病和保持良好健康和生活质量之间的平衡。 我们认为,对于资源丰富和资源有限的环境,需要对开始抗逆转录病毒治疗的适当时间进行评估。必须对推迟抗逆转录病毒治疗的治疗策略进行评估。

项目成果

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Kiat Ruxrungtham其他文献

Kiat Ruxrungtham的其他文献

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{{ truncateString('Kiat Ruxrungtham', 18)}}的其他基金

Data Management and Statistical Support
数据管理和统计支持
  • 批准号:
    7900787
  • 财政年份:
    2009
  • 资助金额:
    $ 5.88万
  • 项目类别:
Training Support
培训支持
  • 批准号:
    7900789
  • 财政年份:
    2009
  • 资助金额:
    $ 5.88万
  • 项目类别:
Pharmacy Support
药房支持
  • 批准号:
    7900784
  • 财政年份:
    2009
  • 资助金额:
    $ 5.88万
  • 项目类别:
Treatment of HIV/Tuberculosis Co-Disease
HIV/结核病合并疾病的治疗
  • 批准号:
    7900782
  • 财政年份:
    2009
  • 资助金额:
    $ 5.88万
  • 项目类别:
Laboratory Support
实验室支持
  • 批准号:
    7900791
  • 财政年份:
    2009
  • 资助金额:
    $ 5.88万
  • 项目类别:
Reduction of Risk Behaviour in People with HIV Infection
减少艾滋病毒感染者的危险行为
  • 批准号:
    7900783
  • 财政年份:
    2009
  • 资助金额:
    $ 5.88万
  • 项目类别:
Administrative Support
行政支持
  • 批准号:
    7900790
  • 财政年份:
    2009
  • 资助金额:
    $ 5.88万
  • 项目类别:
Simplfied Monitoring of Antiretroviral Therapy
简化抗逆转录病毒治疗监测
  • 批准号:
    7900779
  • 财政年份:
    2009
  • 资助金额:
    $ 5.88万
  • 项目类别:
Neurodevelopment
神经发育
  • 批准号:
    7668264
  • 财政年份:
    2008
  • 资助金额:
    $ 5.88万
  • 项目类别:
Data Management and Statistical Suppport
数据管理和统计支持
  • 批准号:
    7668253
  • 财政年份:
    2008
  • 资助金额:
    $ 5.88万
  • 项目类别:

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