Laboratory Support

目标 为CIPRA项目提供实验室支持 为能力有限的研究中心提供艾滋病毒中心实验室设施 在可能的情况下发展区域实验室的能力 制定质量保证/质量控制程序，以监测实验室间和实验室内的变异性，并使实验室程序标准化 用于专门的研究终点测定 提供药学水平药物非临床研究质量管理规范、实验室原则的区域培训计划 技术与质量管理 具体目标 根据项目增加的活动雇用额外的技术人员 购买更多的实验室设备，以适应与项目相关的活动增加 采购额外的行政基础设施，以支持这一实验室核心 扩大现有的实验室设施，以适应与CIPRA计划相关的额外活动 方法 该署会聘用两名全职化验师和三名助理化验师。这个数字 根据艾滋病毒-NAT实验室工作量分配的现行公式。实验室 行政助理将负责监督四个项目的文书工作。由于艾滋病毒-NAT将是 对于许多中心实验室来说，离心机、生物安全柜和流式细胞仪是必需的， 预期活动增加。现有的设备足够了。 所有四个项目的长期标本储存将需要额外的-80 ℃冰柜。据设想， 长期储存将发生在HIV-NAT。一个系统的标本运输之间的网站和HIV-NAT使用地面 由于固体碳供应的不可靠性，将发展便携式液氮罐的航空运输 二氧化碳（干冰）在偏远地区。在装运前，需要在区域研究中心进行临时本地储存。 将为此购买用于临时样本储存的小型冰柜。

Objectives To provide laboratory support for this CIPRA program To provide central laboratory facilities at HIV-NAT for those sites with limited capacity To develop laboratory capacity in regional sites where possible To develop QA/QC programs to monitor inter- and intra-laboratory variability and to standardize laboratory procedures for specialized study endpoint assays To provide regional training program in principles of pharmaceutical level Good Laboratory Practice, laboratory techniques and quality management Specific aims To employ additional technical personnel in accordance with increased activity according to the projects To purchase additional laboratory equipment to accommodate the increased activity associated with the projects To procure additional administrative infrastructure to support this laboratory core To expand the existing laboratory facilities to accommodate additional activity associated with the CIPRA program Methods Two full-time laboratory technologists and three assistant laboratory technicians will be employed. This number is based on the current formula for workload distribution for employment at the HIV-NAT laboratory. A laboratory administrative assistant will be employed to oversee the clerical aspects of the four projects. As HIV-NAT will be the central laboratory for many sites, the centrifuge, biological safety cabinet and flow cytometer are needed with the expected increase in activity. Other existing equipment is adequate. Additional -80 deg freezers will be needed for-long term specimen storage for all four projects. It is envisaged that most long-term storage will occur at HIV-NAT. A system of specimen transport between the sites and HIV-NAT using ground and air transport with portable liquid nitrogen tanks will be developed due to the unreliable supply of solid carbon dioxide (dry ice) in remote sites. There will be a need for temporary local storage at regional sites prior to shipment. Small freezers for temporary specimen storage will be purchased for this purpose.