High-performance Biocompatible GIC System with Permanent Antibacterial Function

具有永久抗菌功能的高性能生物相容性GIC系统

• 批准号: 7827813
• 负责人: DONG XIE
• 金额: $ 39.84万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7827813
• 关键词: Achievement; Address; Adherence; Adhesions; Aging; Ammonium; Anti-Bacterial Agents; Area; Biocompatible; Biocompatible Materials; Biological Assay; Cations; Cell model; Composite Dental Resin; Composite Resins; Dental; Dental Amalgam; Dental Pulp; Dental Restoration Failure; Dental caries; Dentin; Dentistry; Dentists; Disadvantaged; Drug Formulations; Evaluation; Exhibits; Face; Failure; Fatigue; Fibroblasts; Filler; Fluorides; Fracture; Fuji II LC cement; Glass; Glass Ionomer Cements; Goals; Hardness; In Vitro; Incidence; Intervention; Liquid substance; Longevity; Mechanics; Methacrylates; Microbial Biofilms; Minimum Inhibitory Concentration measurement; Modeling; Molecular Structure; Molecular Weight; Performance; Plant Resins; Polymers; Powder dose form; Prevention; Preventive; Property; Research; Research Project Grants; Resistance; Risk; Screening procedure; Secondary to; Series; Services; Shapes; Streptococcus mutans; Stress; System; Techniques; Technology; Testing; Tetrazolium; Time; Tooth structure; Upper arm; Viscosity; Water; Work; bactericide; base; biomaterial compatibility; combat; dental adhesive; design; in vitro activity; minimally invasive; nanoscale; novel; oral bacteria; physical property; polymerization; polymerization shrinkage; prevent; response; restoration; restorative dentistry; tool

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (13) Smart Biomaterials-Theranostics and specific Challenge Topic, 13-DE-102: Dental Resin Composite and Caries. It is known that half of all dental restorations fail within 10 years and replacing them consumes 60% of the average dentist's practice time. Secondary caries and fracture of the restoration are found to be the main reasons for restoration failure. To face these challenges, dental restoratives must be made strong and stable enough to withstand fracture and wear, and antibacterial enough to prevent or reduce secondary caries. The overall goal of this research project is to develop a novel high-performance biocompatible glass-ionomer cement (GIC) system with permanent antibacterial function to combat bacterial destruction, prevent biofilm formation and withstand fracture and wear for enhancing restoration longevity. Currently, none of the commercially available GICs are being used for high stress- and high wear-bearing restorations as are composite resins, due to their poor wear-resistance and low mechanical strengths, although these cements have numerous advantages over composite resins. Furthermore, none of the dental restoratives are permanently antibacterial, which significantly increases the incidence of secondary caries. We have demonstrated that novel star-shaped polyacid-constructed resin-modified GIC (RMGIC) exhibited outstanding and comparable wear-resistance as well as mechanical strengths to some of the current composite resins, in addition to its inherent adhesion to tooth that composite resins do not have. In this challenge proposal, we propose to develop a novel antibacterial and biocompatible high-performance RMGIC system constructed with well- designed highly-branched polymers along with covalently attached quaternary ammonium cations (Quats) for stronger and longer-lasting restoration as well as secondary cavity prevention or reduction. This system is uniquely designed to combine all the major advantages but minimize the disadvantages that composite resins, conventional GICs and RMGICs have. In this research, a series of well-designed as well as well- constructed highly-branched polymers and a series of new antibacterial Quats will be synthesized and used to formulate a high-performance GIC system with permanent antibacterial function. Flexural strength, wear- resistance and viscosity will be used as primary screening tools for cement formulation and optimization. Bactericidal testing against Streptococcus mutans will be used as a primary screening tool for Quat's antibacterial evaluation. Important mechanical properties, physical properties, in vitro antibacterial activity and in vitro biocompatibility of the optimal system will be evaluated. Successful achievement of the goals of this project will positively impact the fields of restorative, preventive and minimally invasive dentistry and early caries intervention by providing a new attractive antibacterial adhesive dental restorative. Secondary caries and fracture of the restoration are found to be the main reasons for dental restoration failure. To face these challenges, dental restoratives must be made strong and stable enough to withstand fracture and wear, and antibacterial enough to prevent or reduce secondary caries. The objective of this research is to develop a novel high-performance biocompatible glass-ionomer cement system with permanent antibacterial function to combat bacterial destruction, prevent biofilm formation and withstand fracture and wear for enhancing restoration longevity.

描述（由申请人提供）： 该申请涉及广泛的挑战领域（13）智能生物材料 - 静脉液和特定的挑战主题，13-DE-102：牙科树脂复合材料和龋齿。众所周知，所有牙科修复体的一半在10年内失败，并取代他们消耗了平均牙医练习时间的60％。发现次要龋齿和修复的断裂是恢复失败的主要原因。为了面对这些挑战，必须使牙齿恢复效果足够强大，足以承受骨折和磨损，并且足以预防或减少次要龋齿。该研究项目的总体目标是开发具有永久性抗菌功能的新型高性能生物相容性玻璃离子水泥（GIC）系统，以抵抗细菌破坏，防止生物膜形成并承受骨折和磨损，以增强恢复寿命。当前，由于这些水泥比复合树脂具有许多优势，但由于它们的磨损差和机械强度较低，因此没有像复合树脂那样用于高应力和高磨损恢复的高应力和高磨损修复体，而没有任何商业上可用的GIC。此外，牙齿修复剂均未永久性抗菌作用，这显着增加了继发性龋齿的发生率。我们已经证明了新型的星形多酸化树脂修饰的GIC（RMGIC）表现出出色的可比磨损耐药性以及与当前一些复合树脂的机械强度，除了其对牙齿的固有粘合剂外，该复合物树脂还没有。在这项挑战提案中，我们建议开发一种新型的抗菌和生物相容性的高性能RMGIC系统，该系统由精心设计的高度支线高度聚合物以及共同附着的Quaternary铵阳离子（Quats）构建，以实现更强大，更持久的恢复以及预防或减少次级液化或减少。该系统的设计独特，旨在结合所有主要优势，但最大程度地减少了复合树脂，常规GIC和RMGICS的缺点。在这项研究中，将合成一系列精心设计的且构建的高度支线高度分支聚合物以及一系列新的抗菌量子，并用于制定具有永久性抗菌功能的高性能GIC系统。弯曲强度，耐磨损和粘度将用作水泥配方和优化的主要筛选工具。针对链球菌突变的杀菌测试将用作Quat抗菌评估的主要筛选工具。将评估重要的机械性能，物理特性，体外抗菌活性和最佳系统的体外生物相容性。成功实现该项目的目标将通过提供一种新的有吸引力的抗菌粘合剂牙齿修复剂，从而对修复，预防和微创牙科和早期龋齿干预的领域产生积极影响。发现次要龋齿和修复的断裂是牙齿恢复衰竭的主要原因。为了面对这些挑战，必须使牙齿恢复效果足够强大，足以承受骨折和磨损，并且足以预防或减少次要龋齿。这项研究的目的是开发一种具有永久性抗菌功能的新型高性能生物相容性玻璃离子化水泥系统，以打击细菌破坏，防止生物膜形成并承受骨折和磨损，以增强恢复寿命。