Novel Amino Acid-Based Glass-Ionomer Biomaterials

新型氨基酸基玻璃离聚物生物材料

• 批准号: 6737905
• 负责人: DONG XIE
• 金额: $ 27.73万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-19 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6737905
• 关键词: aminoacid; bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biotechnology; chemical synthesis; dental materials; glass; interdisciplinary collaboration; laboratory rat; orthopedics; polymers

DESCRIPTION (provided by applicant): It is known that resin-modified glass-ionomer cement (RMGIC) is an attractive dental restorative because it has enhanced mechanical strength, bonding and handling properties. However, a disadvantage of this cement is that it contains a large quantity of 2-hydroxyethyl methacrylate (HEMA). Since unreacted HEMA is cytotoxic to pulp and surrounding tissues, elimination of HEMA could make this "intelligent" cement more attractive for both dental and orthopedic applications. We have demonstrated that new and novel amino acid-modified and non-HEMA containing RMGICs exhibit significantly improved mechanical strengths, adhesion and self-etching capabilities. The objective of this research is to develop these novel amino acid based glass-ionomers for both dental and orthopedic applications, in response to NIBIB's RFA for development of novel biomaterials with improved biological and mechanical properties. In this research, inexpensive and biostable amino acid-based polycarboxylic acid will be synthesized and formulated with amino acid derivatives to form an innovative non-HEMA containing RMGIC system. Design of Experiment (DOE) methodology will be applied to optimize molar ratio, molecular weight, grafting ratio of synthesized poly(amino acid), formulations and filler contents. Mechanical strengths and other physical properties of the new cements will be evaluated. The proposed amino acid-based cements will provide extra salt-bridges, thus enhancing adhesion and mechanical strengths. In vitro direct cell contact as well as methylthiazolyldiphenyl tetrazolium (MTT) studies and in vivo bone response will be conducted to determine the biocompatibility and bioactivity of the new cements. Novel restoratives for both dentistry and orthopedics should be an outcome of this basic research to establish commercial biomaterials for future industrial development. Successful achievement of the goal of this project will significantly impact the field of restorative dentistry and orthopedic surgery. This project will create a university-wide collaboration between synthetic polymer chemist, biomaterials scientist, biomechanical engineer and clinical dentist. This project will also provide an ideal training environment for biomedical engineering students because it will allow them, through close interactions with the collaborators from different disciplines, to develop a broad perspective on biomaterials research.

说明(申请人提供)：众所周知，树脂改性玻璃离子水门汀(RMGIC)是一种有吸引力的牙科修复剂，因为它具有更高的机械强度、粘结力和操作性能。然而，这种水泥的缺点是它含有大量的甲基丙烯酸羟乙酯(HEMA)。由于未反应的HEMA对牙髓和周围组织具有细胞毒性，消除HEMA可以使这种“智能”粘固剂在牙科和整形外科应用中更具吸引力。我们已经证明，新的和新型的氨基酸修饰的和非HEMA的RMGIC显示出显著的机械强度、附着力和自腐蚀能力。本研究的目的是为了响应NIBIB的RFA，开发这些用于牙科和整形外科的新型氨基酸玻璃离子，以开发具有更好的生物和机械性能的新型生物材料。在本研究中，我们将合成价格低廉且生物稳定的氨基酸基聚羧酸，并将其与氨基酸衍生物复配，形成一种创新的非HEMA RMGIC体系。采用实验设计(DOE)方法对合成的聚氨基酸的摩尔比、相对分子质量、接枝率、配方和填充剂含量进行优化。将对新水泥的机械强度和其他物理性能进行评估。拟议的氨基酸基水泥将提供额外的盐桥，从而提高粘附力和机械强度。体外直接细胞接触、四甲基偶氮唑盐(四甲基偶氮唑盐)研究和体内骨反应将被用来确定新型骨水泥的生物相容性和生物活性。用于牙科和骨科的新型修复剂应该是这项基础研究的成果，以建立用于未来工业发展的商业生物材料。该项目目标的成功实现将对修复性牙科和矫形外科领域产生重大影响。该项目将在合成聚合物化学家、生物材料科学家、生物机械工程师和临床牙医之间建立一个大学范围内的合作。该项目还将为生物医学工程专业的学生提供理想的培训环境，因为它将使他们通过与来自不同学科的合作者的密切互动，发展对生物材料研究的广阔视角。