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Novel Nanostructured Dental Glass-Ionomers for Advanced Dental Restoratives

用于高级牙科修复的新型纳米结构牙科玻璃离子聚合物

基本信息

批准号：
7361411
负责人：
DONG XIE
金额：
$ 17.94万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-03-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7361411
关键词：
ARHGEF5 gene Achievement Aging Basic Science Biocompatible Biocompatible Materials Biological Assay Biomedical Engineering Class Clinical Collaborations Composite Dental Resin Composite Resins Decompression Sickness Dental Dental Materials Dental Students Dental caries Dentin Dentists Development Discipline Drug Formulations Electrons Environment Evaluation Exhibits Filler Fluorides Fracture Fuji II LC cement Gel Chromatography Glass Glass Ionomer Cements Goals Hardness Hybrids In Vitro Intervention Length Light Liquid substance Magnetic Resonance Spectroscopy Mechanics Methacrylates Microscopic Modification Molecular Weight Nanostructures Nuclear Object Attachment Pediatric Dentistry Plant Resins Polymers Powder dose form Property Research Research Project Grants Resistance Scanning Scheme Scientist Screening procedure Series Shapes Silicon Dioxide Site Spectrum Analysis Stress Students Surface System Techniques Technology Testing Tetrazolium Training Viscosity Water Work acrylic acid aqueous base biomaterial compatibility cytotoxicity dental adhesive experience glass ionomer improved innovation macromolecule nanoparticle nanosized nanostructured novel physical property polymerization polymerization shrinkage response restoration restorative dentistry restorative material tool

项目摘要

DESCRIPTION (provided by applicant): Currently, none of the commercially available glass-ionomer cements (GICs) are being used for Class I and II restorations due to their poor wear-resistance and low mechanical strengths, although these cements have numerous advantages over composite resins. We have demonstrated that novel star-shape polyacid-constructed hybrid glass-ionomer cement exhibits outstanding and comparable wear resistance as well as mechanical strengths to current composite resins. Further, nanofiller-strengthened GIC showed significantly improved hardness and wear-resistance. Combined with surface-modified nanofillers, the above star-shape polymer-constructed GIC may be developed into a novel dental restorative for sites requiring wear-resistance and high-strength restorations. The objective of this research is to develop a novel biocompatible nanostructured light-cured glass-ionomer system with comparable wear-resistance and mechanical strengths to current dental composite resins, in response to NIDCR's FOA for Nanostructured Dental Composite Restorative Materials. In this research, a series of starshape poly (acrylic acid)s and nanoparticles with polymer surface modification will be synthesized using advanced aqueous ATRP technology. Both nanosized functional polymers and fillers will be characterized and used to construct a novel biocompatible high-strength light-cured GIC. The system will be optimized based upon molecular weight, length of the polymer on nanofiller surface, tethering ratio of methacrylate on the polymer, nanofiller loading ratio, total filler powder/polymer liquid ratio, working viscosity, and efficiency of the initiator system. Flexural strength, hardness and viscosity will be used as primary screening tools for evaluation. Wear resistance and fracture toughness will be used as secondary screening tools. Other important mechanical and physical properties will also be evaluated. In vitro biocompatibility of the new system will be evaluated using MTT assay. This project will build on an ongoing collaboration between a dental materials scientist with strong polymer synthesis experience and a clinical dentist with strong dental materials research background. Successful achievement of the goals of this project will positively impact the fields of Restorative Dentistry and early caries intervention by providing a new attractive adhesive dental restorative. This project will also provide an ideal training environment for biomedical engineering students and dental materials students because it will allow them, through close interactions with the collaborators from different disciplines, to develop a broad perspective on dental materials research.

描述（申请人提供）：目前，市售的玻璃离子水门汀（GIC）由于其耐磨性差和机械强度低，没有一种被用于 I 类和 II 类修复体，尽管这些水门汀比复合树脂具有许多优点。我们已经证明，新型星形聚酸结构的混合玻璃离子水门汀具有与当前复合树脂相当的出色的耐磨性和机械强度。此外，纳米填料强化的 GIC 显示出显着提高的硬度和耐磨性。上述星形聚合物结构的GIC与表面改性纳米填料相结合，可开发成一种新型牙科修复材料，用于需要耐磨和高强度修复的部位。本研究的目的是开发一种新型生物相容性纳米结构光固化玻璃离聚物系统，其耐磨性和机械强度可与当前牙科复合树脂相媲美，以响应 NIDCR 的纳米结构牙科复合修复材料 FOA。在这项研究中，将利用先进的水性ATRP技术合成一系列具有聚合物表面改性的星形聚丙烯酸和纳米颗粒。纳米功能聚合物和填料都将被表征并用于构建新型生物相容性高强度光固化 GIC。该系统将根据分子量、纳米填料表面聚合物的长度、聚合物上甲基丙烯酸酯的束缚比、纳米填料负载比、总填料粉末/聚合物液体比、工作粘度和引发剂系统的效率进行优化。弯曲强度、硬度和粘度将作为评估的主要筛选工具。耐磨性和断裂韧性将作为二次筛选工具。其他重要的机械和物理性能也将被评估。新系统的体外生物相容性将使用 MTT 测定进行评估。该项目将建立在具有丰富聚合物合成经验的牙科材料科学家和具有强大牙科材料研究背景的临床牙医之间持续合作的基础上。该项目目标的成功实现将通过提供一种新的有吸引力的粘合牙科修复剂，对修复牙科和早期龋齿干预领域产生积极影响。该项目还将为生物医学工程学生和牙科材料学生提供理想的培训环境，因为它将使他们能够通过与来自不同学科的合作者的密切互动，对牙科材料研究形成广阔的视野。