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High-performance Biocompatible GIC System with Permanent Antibacterial Function

具有永久抗菌功能的高性能生物相容性GIC系统

基本信息

批准号：
7933990
负责人：
DONG XIE
金额：
$ 39.9万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-17 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7933990
关键词：
Achievement Address Adherence Adhesions Aging Ammonium Anti-Bacterial Agents Area Biocompatible Biocompatible Materials Biological Assay Cations Cell model Composite Dental Resin Composite Resins Dental Dental Amalgam Dental Pulp Dental Restoration Failure Dental caries Dentin Dentistry Dentists Disadvantaged Drug Formulations Evaluation Exhibits Face Failure Fatigue Fibroblasts Filler Fluorides Fracture Fuji II LC cement Glass Glass Ionomer Cements Goals Hardness In Vitro Incidence Intervention Liquid substance Longevity Mechanics Methacrylates Microbial Biofilms Minimum Inhibitory Concentration measurement Modeling Molecular Structure Molecular Weight Performance Plant Resins Polymers Powder dose form Prevention Preventive Property Research Research Project Grants Resistance Risk Screening procedure Secondary to Series Services Shapes Streptococcus mutans Stress System Techniques Technology Testing Tetrazolium Time Tooth structure Viscosity Water Work arm bactericide base biomaterial compatibility combat dental adhesive design in vitro activity minimally invasive nanoscale novel oral bacteria physical property polymerization polymerization shrinkage prevent response restoration restorative dentistry tool

项目摘要

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (13) Smart Biomaterials-Theranostics and specific Challenge Topic, 13-DE-102: Dental Resin Composite and Caries. It is known that half of all dental restorations fail within 10 years and replacing them consumes 60% of the average dentist's practice time. Secondary caries and fracture of the restoration are found to be the main reasons for restoration failure. To face these challenges, dental restoratives must be made strong and stable enough to withstand fracture and wear, and antibacterial enough to prevent or reduce secondary caries. The overall goal of this research project is to develop a novel high-performance biocompatible glass-ionomer cement (GIC) system with permanent antibacterial function to combat bacterial destruction, prevent biofilm formation and withstand fracture and wear for enhancing restoration longevity. Currently, none of the commercially available GICs are being used for high stress- and high wear-bearing restorations as are composite resins, due to their poor wear-resistance and low mechanical strengths, although these cements have numerous advantages over composite resins. Furthermore, none of the dental restoratives are permanently antibacterial, which significantly increases the incidence of secondary caries. We have demonstrated that novel star-shaped polyacid-constructed resin-modified GIC (RMGIC) exhibited outstanding and comparable wear-resistance as well as mechanical strengths to some of the current composite resins, in addition to its inherent adhesion to tooth that composite resins do not have. In this challenge proposal, we propose to develop a novel antibacterial and biocompatible high-performance RMGIC system constructed with well- designed highly-branched polymers along with covalently attached quaternary ammonium cations (Quats) for stronger and longer-lasting restoration as well as secondary cavity prevention or reduction. This system is uniquely designed to combine all the major advantages but minimize the disadvantages that composite resins, conventional GICs and RMGICs have. In this research, a series of well-designed as well as well- constructed highly-branched polymers and a series of new antibacterial Quats will be synthesized and used to formulate a high-performance GIC system with permanent antibacterial function. Flexural strength, wear- resistance and viscosity will be used as primary screening tools for cement formulation and optimization. Bactericidal testing against Streptococcus mutans will be used as a primary screening tool for Quat's antibacterial evaluation. Important mechanical properties, physical properties, in vitro antibacterial activity and in vitro biocompatibility of the optimal system will be evaluated. Successful achievement of the goals of this project will positively impact the fields of restorative, preventive and minimally invasive dentistry and early caries intervention by providing a new attractive antibacterial adhesive dental restorative. Secondary caries and fracture of the restoration are found to be the main reasons for dental restoration failure. To face these challenges, dental restoratives must be made strong and stable enough to withstand fracture and wear, and antibacterial enough to prevent or reduce secondary caries. The objective of this research is to develop a novel high-performance biocompatible glass-ionomer cement system with permanent antibacterial function to combat bacterial destruction, prevent biofilm formation and withstand fracture and wear for enhancing restoration longevity.

描述（由申请人提供）：该应用解决了广泛的挑战领域 (13) 智能生物材料治疗诊断学和特定挑战主题 13-DE-102：牙科树脂复合材料和龋齿。据了解，一半的牙齿修复体会在 10 年内失效，而更换牙齿会占用牙医平均 60% 的执业时间。继发龋和修复体断裂被发现是修复体失败的主要原因。为了应对这些挑战，牙科修复体必须足够坚固和稳定，以承受断裂和磨损，并且足够抗菌，以预防或减少继发龋齿。该研究项目的总体目标是开发一种新型高性能生物相容性玻璃离子水门汀（GIC）系统，该系统具有永久抗菌功能，可对抗细菌破坏、防止生物膜形成并抵抗断裂和磨损，从而提高修复体的使用寿命。目前，尽管这些水泥与复合树脂相比具有许多优点，但由于其耐磨性差和机械强度低，目前市售的 GIC 还没有像复合树脂那样用于高应力和高磨损修复体。此外，没有一种牙科修复剂具有永久抗菌性，这会显着增加继发龋的发生率。我们已经证明，新型星形聚酸结构树脂改性 GIC（RMGIC）除了具有复合树脂所不具备的对牙齿的固有粘附力外，还表现出与某些现有复合树脂相当的出色的耐磨性和机械强度。在这一挑战提案中，我们建议开发一种新型抗菌和生物相容性高性能RMGIC系统，该系统由精心设计的高度支化聚合物和共价连接的季铵阳离子（Quats）构成，以实现更强、更持久的修复以及预防或减少二次蛀牙。该系统经过独特设计，结合了复合树脂、传统 GIC 和 RMGIC 的所有主要优点，同时最大限度地减少了其缺点。本研究将合成一系列精心设计和构建的高支化聚合物和一系列新型抗菌季铵盐，并用于配制具有永久抗菌功能的高性能GIC系统。弯曲强度、耐磨性和粘度将用作水泥配方和优化的主要筛选工具。针对变形链球菌的杀菌测试将用作季铵盐抗菌评估的主要筛选工具。将评估最佳系统的重要机械性能、物理性能、体外抗菌活性和体外生物相容性。该项目目标的成功实现将通过提供一种新型有吸引力的抗菌粘合牙科修复剂，对修复、预防和微创牙科以及早期龋齿干预领域产生积极影响。继发龋和修复体断裂被发现是牙齿修复体失败的主要原因。为了应对这些挑战，牙科修复体必须足够坚固和稳定，以承受断裂和磨损，并且足够抗菌，以预防或减少继发龋齿。本研究的目的是开发一种新型高性能生物相容性玻璃离子水门汀系统，具有永久抗菌功能，可对抗细菌破坏、防止生物膜形成、抵抗断裂和磨损，从而提高修复体的使用寿命。