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Synaptic Afferent-Target Relations in Gustatory NTS

味觉 NTS 中的突触传入-目标关系

基本信息

批准号：
7892031
负责人：
ALEV ERISIR
金额：
$ 15.4万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7892031
关键词：
Address Adult Anatomy Axon Behavioral Biological Models Brain Brain Stem Brain region Cells Chemicals Communication Confocal Microscopy Defect Dendritic Cells Dependence Development Electron Microscopy Environment Evaluation Faculty Feedback Fostering Glutamate Receptor Glutamates Incidence Individual Lead Mediating Modeling Molecular Morphology N-Methyl-D-Aspartate Receptors Nature Nerve Neurons Nucleus solitarius Outcome Pathway interactions Pattern Perforation Plastics Procedures Property Relative (related person)Research Role Sensory Source Specificity Stimulus Structure Synapses Synaptic plasticity System Taste Perception Techniques Testing Trees Variant Vesicle Visual system structure afferent nerve base cell type chorda tympani density design developmental plasticity glossopharyngeal in vivo indexing neural circuit novel postsynaptic programs receptor research study sensory stimulus sensory system

项目摘要

The malleability of neuronal circuits by environmental conditions is a crucial property in developing brain in fostering adaptive development of perceptual and behavioral faculties. This is particularly obvious in sensory systems. Brainstem taste pathway is potentially a suitable model system to understand competitive interactions and activity dependent reorganization, two possible mechanisms of neuronal malleability, also termed plasticity. Understanding the mechanisms of plasticity is a major step in developing strategies to avoid developmental defects, and to foster normal development of the brain function. A research program is designed to determine whether taste circuits have cellular and molecular components that may allow sensory systems to undergo changes during deviations from normal environmental stimuli. The first study aims to obtain evidence for whether distinct gustatory nerves converge upon individual neurons, using a combination of anterograde and retrograde tract-tracing anatomy, confocal microscopy using multiple markers and electron microscopy. How and when in development such input convergences occur will have important outcomes for our understanding of the role of competitive interactions in plasticity. The second aim of the proposed project will examine fine structure and glutamate receptor signature of axons that are destined to withdraw during development of taste pathways. The potential findings of the proposed experiments shall provide novel information on target selectivity of two gustatory nerves, as well as underlining gustatory afferent development as a model to study developmental plasticity and lifelong synaptic stability.

神经元回路受环境条件影响的可塑性是一个至关重要的特性开发大脑促进知觉和行为的适应性发展院系。这在感觉系统中尤其明显。脑干味觉通路是可能是一个合适的模型系统来理解竞争性互动和活动依赖性重组，神经元可塑性的两种可能机制，称为可塑性。了解可塑性机制是迈出的重要一步制定避免发育缺陷并促进正常发育的策略的大脑功能。一项研究计划旨在确定味觉回路是否具有可以让感觉系统经历的细胞和分子成分偏离正常环境刺激时发生的变化。第一项研究旨在获得证据证明不同的味觉神经是否汇聚到单个神经元上，结合顺行和逆行束追踪解剖学、共聚焦使用多个标记的显微镜和电子显微镜。如何以及何时进入这种输入融合的发展将对我们产生重要的成果了解竞争性相互作用在可塑性中的作用。第二个目标是拟议的项目将检查轴突的精细结构和谷氨酸受体特征它们注定会在味觉通路的发育过程中消失。潜力拟议实验的结果应提供有关目标选择性的新信息两个味觉神经，以及强调味觉传入发育作为研究发育可塑性和终生突触稳定性的模型。