Brain Mechanisms of Anticipatory Processing in Anxiety Disorders

焦虑症预期处理的大脑机制

• 批准号: 7895583
• 负责人: Jack B Nitschke
• 金额: $ 9.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7895583
• 关键词: Address; Adverse event; Affect; Amygdaloid structure; Anterior; Anxiety; Anxiety Disorders; Area; Aversive Stimulus; Brain; Brain region; Client; Clinical; Comorbidity; Data; Deep Brain Stimulation; Defense Mechanisms; Development Plans; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Economic Burden; Environment; Event; Exposure to; Feeling hopeless; Figs - dietary; Fright; Functional disorder; Future; Generalized Anxiety Disorder; Hippocampus (Brain); Human; Individual; Insula of Reil; Intervention; Investigation; Knowledge; Laboratories; Major Depressive Disorder; Mental Depression; Mental disorders; Methods; Modeling; Neurobiology; Neurosciences Research; Obsessive-Compulsive Disorder; Outcome; Patients; Pattern; Pharmaceutical Preparations; Population; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Psychiatry; Psychotherapy; Recovery; Recruitment Activity; Reporting; Research; Research Personnel; Residual state; Resources; Sampling; Schools; Services; Specific Phobia; Specificity; Sum; Symptoms; System; Testing; Training; Transcranial magnetic stimulation; Uncertainty; Work; adverse outcome; base; career development; cingulate cortex; conditioned fear; design; emotional stimulus; interest; knowledge base; neuromechanism; novel strategies; programs; relating to nervous system; response; social; tool; white matter

DESCRIPTION (provided by applicant): Anxiety disorders are a debilitating form of mental illness that affect many people and carry a high societal and economic burden. A central feature of these disorders is the excessive anticipation of potential adverse outcomes. Considerable work in the candidate's and others' labs has identified multiple brain areas recruited during the anticipation of aversive events. The primary research objectives of this application are to probe these areas for abnormalities during anticipation in anxiety disorder patients and to examine the impact of uncertainty and uncontrollability, which figure prominently in anxiety. The planned research will also assess functional associations and white matter connections among the brain networks identified. In service of that, training in functional and structural connectivity methods is the major focus of the career development plan. These rapidly developing areas examining connectivity are an obvious next step for the candidate's research program and career development and will be crucial in his efforts to continue contributing to our developing knowledge base about brain function in anxiety. The environment is ideal for the pursuit of these research and career development objectives, with outstanding facilities, collaborators, and resources as well as a high degree of support from both the Department of Psychiatry and the Waisman Center. The proposed research will examine anticipatory function in generalized anxiety disorder and social anxiety disorder using a picture paradigm designed and developed in the candidate's laboratory over the past 7 years. The high levels of comorbidity with depression for these two anxiety disorders will be systematically investigated by including patients with major depressive disorder. The discovery of neural abnormalities in anticipatory processes should add to the body of work already being used in developing new clinical tools for directly targeting specific brain regions in anxiety and depression, such as transcranial magnetic stimulation, epidural electrocortical stimulation, and deep brain stimulation. Psychotherapy clients may benefit from greater focus of intervention strategies on anticipatory processes relevant to their symptoms. Research findings from the proposed project might have implications for determining which individuals would be likely to benefit from a particular treatment, building on recent findings by the candidate and his colleagues that greater anticipatory activity in the anterior cingulate predicts better response to an 8-week medication trial.

描述（由申请人提供）：焦虑症是一种使人衰弱的精神疾病，影响许多人，并带来很高的社会和经济负担。这些疾病的一个中心特征是对潜在不良后果的过度预期。在候选人和其他人的实验室中进行的大量工作已经确定了在预期厌恶事件时招募的多个大脑区域。本申请的主要研究目标是在焦虑症患者的预期期间探测这些区域的异常，并检查不确定性和不可控性的影响，这在焦虑中占突出地位。计划中的研究还将评估已确定的大脑网络之间的功能关联和白色物质联系。为此，职业发展计划的主要重点是职能和结构连接方法方面的培训。 这些快速发展的领域检查连接是候选人的研究计划和职业发展的一个明显的下一步，并将在他的努力继续为我们发展有关焦虑大脑功能的知识基础做出贡献至关重要。环境是追求这些研究和职业发展目标的理想选择，拥有出色的设施，合作者和资源，以及精神病学系和魏斯曼中心的高度支持。拟议的研究将使用过去7年来在候选人实验室设计和开发的图片范例来检查广泛性焦虑症和社交焦虑症的预期功能。通过纳入重度抑郁症患者，将系统研究这两种焦虑症与抑郁症的高水平共病。预期过程中神经异常的发现应该会增加已经用于开发新的临床工具的工作，这些工具可以直接针对焦虑和抑郁症的特定大脑区域，例如经颅磁刺激，硬膜外皮层电刺激和深部脑刺激。心理治疗的客户可能会受益于更大的干预策略的预期过程相关的症状。拟议项目的研究结果可能对确定哪些人可能从特定治疗中受益具有影响，该候选人及其同事最近的研究结果表明，前扣带的预期活动越大，对8周药物试验的反应越好。