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Neuroanatomy of Anticipation in Anxiety Disorders

焦虑症预期的神经解剖学

基本信息

批准号：
7641084
负责人：
Jack B Nitschke
金额：
$ 29.14万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-20 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7641084
关键词：
Address Affect Affective Agoraphobia Amygdaloid structure Animals Anterior Anxiety Anxiety Disorders Area Attenuated Automobile Driving Award Behavioral Biological Brain Brain region Characteristics Clinical Cognitive Comorbidity Conflict (Psychology)Cues Defense Mechanisms Disease Dorsal Economic Burden Event Exhibits Exposure to Eye Movements Feeling hopeless Figs - dietary Functional Magnetic Resonance Imaging Functional disorder Future Generalized Anxiety Disorder Goals Home environment Human Individual Insula of Reil Intervention K-Series Research Career Programs Knowledge Left Life Magnetic Resonance Imaging Major Depressive Disorder Measurement Modeling Mood Disorders Moods Neuroanatomy Neurobiology Neurosciences Research Occupational Outcome Patient Self-Report Patients Performance Population Prefrontal Cortex Preparation Process Public Speaking Recruitment Activity Reporting Research Research Personnel Schools Social Phobia Sum Symptoms System Testing Uncertainty Withdrawal Work base behavior measurement cingulate cortex conditioning depressed depression design healthy volunteer innovation negative mood neural circuit novel strategies programs psychologic relating to nervous system research study response social

项目摘要

DESCRIPTION (provided by applicant): Anxiety and mood disorders are debilitating conditions that cause tremendous personal suffering and engender a high societal and economic burden. A central feature of these disorders is excessive anticipation of potentially aversive outcomes. While anticipation is critical for successful preparation and adaptation to aversive events, dysfunction in this system can interfere markedly with social and occupational functioning. By investigating the neurobiology of this anticipatory system, neural areas associated with specific functions of anticipation, such as autonomic processing, negative affect, and behavioral withdrawal, can be identified and targeted by psychological or biological treatments. In addition, the proposed event-related functional magnetic resonance imaging (fMRI) studies capitalize on 2 key characteristics of anticipation: uncertainty about the future and an inability to control it. Building on prior research using an anticipation paradigm with 1 warning symbol that predicts aversive pictures and another predicting neutral, the first study will manipulate uncertainty (i.e., predictability of picture content) by including an ambiguous warning symbol that is followed by either aversive or neutral pictures. The second study will manipulate uncontrollability by including a condition in which a behavioral response can shorten picture duration. The influence of uncertainty and uncontrollability on key neural areas in the proposed model for aversive anticipation will be tested with healthy volunteers in the first 2 studies. For the final study, both paradigms will be used with relevant clinical populations-generalized anxiety disorder, social anxiety disorder (social phobia), and major depressive disorder-to determine how the normative circuitry identified in the first 2 studies is aberrant in anxiety and mood disorders. The primary prediction is that there is a neural signature for anxiety disorders that corresponds to a general dysfunction in anticipatory processes engaged by potential aversive outcomes, especially in situations of uncertainty and uncontrollability. In sum, the emphasis of this application on the capacity to anticipate impending danger is a novel approach to the study of affective disorders that is geared toward basic knowledge about the neurobiology of healthy defense mechanisms (e.g., anticipation that results in adaptive response) as well as understanding how dysfunction in this system occurs.

描述（由申请人提供）：焦虑和情绪障碍是一种使人衰弱的疾病，会造成巨大的个人痛苦，并产生很高的社会和经济负担。这些疾病的一个主要特征是过度预期潜在的不良结果。虽然预期对于成功准备和适应厌恶事件至关重要，但该系统的功能障碍会显著干扰社会和职业功能。通过研究这种预期系统的神经生物学，与预期的特定功能相关的神经区域，如自主神经处理、负面影响和行为戒断，可以通过心理或生物治疗来识别和靶向。此外，拟议的事件相关功能磁共振成像（fMRI）研究利用了预期的两个关键特征：对未来的不确定性和对未来的无法控制。在先前研究的基础上，使用一个预测厌恶图片的警告符号和另一个预测中性的预测范式，第一项研究将通过包括一个模糊的警告符号，然后是厌恶或中性的图片，来操纵不确定性（即图片内容的可预测性）。第二项研究将通过包括行为反应可以缩短图像持续时间的条件来操纵不可控性。不确定性和不可控性对厌恶预期模型中关键神经区域的影响将在前两个研究中通过健康志愿者进行测试。在最后的研究中，这两种范式将被用于相关的临床人群——广泛性焦虑障碍、社交焦虑障碍（社交恐惧症）和重度抑郁症——以确定前两项研究中确定的规范回路在焦虑和情绪障碍中是如何异常的。主要的预测是，焦虑障碍的神经特征与潜在的厌恶结果所涉及的预期过程的一般功能障碍相对应，特别是在不确定和不可控的情况下。总而言之，这项应用的重点在于预测即将发生的危险的能力，这是一种研究情感性障碍的新方法，它旨在了解健康防御机制的神经生物学基础知识（例如，导致适应性反应的预期），以及了解该系统的功能障碍是如何发生的。