INBRE: WINTHROP U: FACULTY & UNDERGRADUATE RESEARCH DEVELOPMENT

INBRE：温思罗普大学：教师

• 批准号: 8168153
• 负责人: PATRICK OWENS
• 金额: $ 43.86万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-12 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168153
• 关键词: Address; Affect; Bioinformatics; Biology; Biomedical Research; Cardiac; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Development; Educational Curriculum; Environment; Faculty; Female; Foundations; Funding; Future; Goals; Grant; Health; Hepatitis B Virus; Human; Individual; Institution; Malignant neoplasm of prostate; Mentors; Mentorship; Metals; Minority; Molecular; Obesity; Oncogenic; Organism; Pathway interactions; Play; Positioning Attribute; Process; Proteins; Recruitment Activity; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Science; Scientist; Source; South Carolina; Students; Techniques; Tissues; Training; United States National Institutes of Health; Universities; angiogenesis; cell motility; experience; human disease; improved; laboratory facility; meetings; multidisciplinary; programs; repaired; research and development; tool; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recognition of the critical need to improve the health of South Carolina's citizens and as the State's second largest PUI, Winthrop University proposes to establish a distinctive biomedical research program to focus on major human health concerns. Over the next five years, Winthrop will invest $1.7 million of its own funds to accomplish this goal. Winthrop proposes six research projects focusing on: 1) examining repair mechanisms for cardiac tissue damage, 2) investigating potential mechanisms that regulate angiogenesis and cell motility in prostate cancer, 3) developing new spectroscopic tools to better understand a wide range of specific interactions between metals and molecules in living systems, 4) completing the structural analysis of a protein recently implicated in obesity development, 5) revealing the specific role that oncogenic proteins play in cancer progression by identifying the molecular regions that are critical to these processes, and 6) using bioinformatic techniques to project evolutionary pathways of the Hepatitis B virus. These six projects will be supported by: 1) a biomedical core laboratory facility that includes four new staff scientist positions, and 2) targeted mentorship to provide assistance, advice, and resources to meet individual project goals. Winthrop's molecular biomedical focus provides students with a multidisciplinary perspective that underpins and spans the range of South Carolina's regenerative medicine efforts. Advances in a molecular understanding of human disease processes provide the potential for significant progress in addressing critical problems affecting human health. Winthrop's focus provides tremendous overlap among projects, a multidisciplinary environment for training of students, and the synergistic development of a strong lab core. The specific objectives of Winthrop's program are to: 1) dramatically expand biomedical research capacity, 2) increase the competitiveness of faculty for external biomedical research funding, 3) establish a strong biomedical research infrastructure support core, 4) provide students with a strong interdisciplinary foundation in the biomedical sciences and with experience in biomedical research through the establishment of an integrated chemistry-biology biomedical science curriculum, 5) increase the number and the percentage of biology and chemistry graduates that enter biomedical research fields, and 6) recruit, train and mentor Winthrop's many current and future students from underrepresented groups to increase the number and the percentage of Winthrop female and minority graduates that enter the biomedical research profession.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在认识到迫切需要改善南卡罗来纳州的公民的健康和作为国家的第二大PUI，温斯洛普大学建议建立一个独特的生物医学研究计划，专注于主要的人类健康问题。 在接下来的五年里，温斯洛普将投入170万美元的自有资金来实现这一目标。 温斯洛普提出了六个研究项目，重点是：1）检查心脏组织损伤的修复机制，2）调查调节前列腺癌中血管生成和细胞运动的潜在机制，3）开发新的光谱工具以更好地理解生命系统中金属和分子之间的广泛的特异性相互作用，4）完成最近与肥胖发展有关的蛋白质的结构分析，5）通过识别对这些过程至关重要的分子区域来揭示致癌蛋白在癌症进展中发挥的特定作用，以及6）使用生物信息学技术来预测B型肝炎病毒的进化途径。 这六个项目将得到以下支持：1）生物医学核心实验室设施，包括四个新的科学家职位，2）有针对性的指导，以提供援助，建议和资源，以实现个别项目的目标。温斯洛普的分子生物医学重点为学生提供了一个多学科的角度，支持和跨越南卡罗来纳州的再生医学努力的范围。 在人类疾病过程的分子理解方面的进展为解决影响人类健康的关键问题提供了重大进展的潜力。 温斯洛普的重点提供了项目之间的巨大重叠，多学科环境的学生培训，以及一个强大的实验室核心的协同发展。温斯洛普方案的具体目标是：1）大大扩大生物医学研究能力，2）提高教师的竞争力，为外部生物医学研究资金，3）建立一个强大的生物医学研究基础设施支持核心，4）为学生提供了强大的跨学科基础，在生物医学科学和生物医学研究的经验，通过建立一个综合化学-生物生物医学科学课程，5）增加进入生物医学研究领域的生物学和化学毕业生的数量和百分比，以及6）招募，培训和指导温斯洛普的许多来自代表性不足群体的当前和未来的学生，以增加进入生物医学研究专业的温斯洛普女性和少数民族毕业生的数量和百分比。