INBRE: WINTHROP U: FACULTY & UNDERGRADUATE RESEARCH DEVELOPMENT

INBRE：温思罗普大学：教师

• 批准号: 7610028
• 负责人: PATRICK OWENS
• 金额: $ 42.97万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610028
• 关键词: Address; Affect; Bioinformatics; Biology; Biomedical Research; Cardiac; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Development; Educational Curriculum; Environment; Faculty; Female; Foundations; Funding; Future; Goals; Grant; Health; Hepatitis B Virus; Human; Individual; Institution; Malignant neoplasm of prostate; Mentors; Mentorship; Metals; Minority; Molecular; Numbers; Obesity; Oncogenic; Organism; Pathway interactions; Play; Positioning Attribute; Process; Proteins; Range; Recruitment Activity; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Science; Scientist; Source; South Carolina; Students; Techniques; Tissues; Training; United States National Institutes of Health; Universities; angiogenesis; cell motility; experience; human disease; improved; laboratory facility; multidisciplinary; programs; repaired; research and development; tool; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recognition of the critical need to improve the health of South Carolina's citizens and as the State's second largest PUI, Winthrop University proposes to establish a distinctive biomedical research program to focus on major human health concerns. Over the next five years, Winthrop will invest $1.7 million of its own funds to accomplish this goal. Winthrop proposes six research projects focusing on: 1) examining repair mechanisms for cardiac tissue damage, 2) investigating potential mechanisms that regulate angiogenesis and cell motility in prostate cancer, 3) developing new spectroscopic tools to better understand a wide range of specific interactions between metals and molecules in living systems, 4) completing the structural analysis of a protein recently implicated in obesity development, 5) revealing the specific role that oncogenic proteins play in cancer progression by identifying the molecular regions that are critical to these processes, and 6) using bioinformatic techniques to project evolutionary pathways of the Hepatitis B virus. These six projects will be supported by: 1) a biomedical core laboratory facility that includes four new staff scientist positions, and 2) targeted mentorship to provide assistance, advice, and resources to meet individual project goals. Winthrops molecular biomedical focus provides students with a multidisciplinary perspective that underpins and spans the range of South Carolina's regenerative medicine efforts. Advances in a molecular understanding of human disease processes provide the potential for significant progress in addressing critical problems affecting human health. Winthrops focus provides tremendous overlap among projects, a multidisciplinary environment for training of students, and the synergistic development of a strong lab core. The specific objectives of Winthrops program are to: 1) dramatically expand biomedical research capacity, 2) increase the competitiveness of faculty for external biomedical research funding, 3) establish a strong biomedical research infrastructure support core, 4) provide students with a strong interdisciplinary foundation in the biomedical sciences and with experience in biomedical research through the establishment of an integrated chemistry-biology biomedical science curriculum, 5) increase the number and the percentage of biology and chemistry graduates that enter biomedical research fields, and 6) recruit, train and mentor Winthrop's many current and future students from underrepresented groups to increase the number and the percentage of Winthrop female and minority graduates that enter the biomedical research profession.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 认识到改善南卡罗来纳州公民健康的迫切需要，并且作为该州第二大 PUI，温思罗普大学提议建立一个独特的生物医学研究项目，重点关注重大人类健康问题。 未来五年，Winthrop 将投入 170 万美元自有资金来实现这一目标。 Winthrop提出了六个研究项目，重点关注：1）检查心脏组织损伤的修复机制，2）研究调节前列腺癌中血管生成和细胞运动的潜在机制，3）开发新的光谱工具以更好地了解生命系统中金属和分子之间的广泛特定相互作用，4）完成最近与肥胖发展有关的蛋白质的结构分析，5）揭示致癌物质的具体作用 通过识别对这些过程至关重要的分子区域，蛋白质在癌症进展中发挥作用，6) 使用生物信息学技术来预测乙型肝炎病毒的进化途径。 这六个项目将得到以下支持：1）生物医学核心实验室设施，其中包括四个新的科学家职位，2）有针对性的指导，以提供帮助、建议和资源，以实现各个项目目标。温思罗普的分子生物医学重点为学生提供了多学科视角，支撑并跨越了南卡罗来纳州再生医学工作的范围。 对人类疾病过程的分子理解的进步为解决影响人类健康的关键问题提供了重大进展的潜力。 温思罗普的重点是项目之间的巨大重叠、学生培训的多学科环境以及强大的实验室核心的协同发展。温思罗普项目的具体目标是：1）大幅扩大生物医学研究能力，2）提高教师获得外部生物医学研究经费的竞争力，3）建立强大的生物医学研究基础设施支持核心，4）通过建立化学-生物学综合生物医学科学，为学生提供强大的生物医学跨学科基础和生物医学研究经验 课程，5）增加进入生物医学研究领域的生物和化学毕业生的数量和百分比，以及6）从代表性不足的群体中招募、培训和指导温思罗普的许多当前和未来的学生，以增加进入生物医学研究专业的温思罗普女性和少数族裔毕业生的数量和百分比。