Baylor College of Medicine Cancer Center

描述(由申请人提供)：这是贝勒医学院癌症中心(BCMCC)对NCI指定的初始申请，并在NCI P20规划拨款的第三年提交。贝勒医学院(BCM)位于休斯敦的德克萨斯医疗中心(TMC)，这是美国最大也可能是最复杂的医疗中心，拥有40个成员机构。休斯顿是美国第四大城市，人口非常多样化。BCMCC是一个联合体癌症中心，BCM是主要合作伙伴，我们的四家附属医院--德克萨斯儿童医院、圣卢克圣公会医院、德巴基退伍军人事务医疗中心和本陶布综合医院--作为正式的临床合作伙伴。此外，作为创建自己的门诊护理设施的BCM战略的一部分，BCMCC正在牵头规划将于2008年完成的综合多学科癌症诊所。BCMCC于2002年正式成立，目的是整合BCM和我们的合作伙伴已经强大和有组织的科学和临床项目，并创造新的协同效应和利用这一独特环境的项目。TMC独特的环境为科学、临床和教育合作创造了许多机会，BCMCC充分利用了这一机会。 BCMCC获得了成功完成这项任务的资源和权力，并在过去三年中取得了令人振奋的进展。它现在有260多个正式成员，这项提案中记录的与癌症相关的年度研究资金总额接近1亿美元，其中近4000万美元来自NCI。通过P-20进程组织的8个研究和翻译方案仍然存在，并正在变得更加强大。这些专业是癌症生物学、分子癌变、核受体、乳腺癌、癌细胞和基因治疗、前列腺癌、癌症预防和儿童癌症。此外，虽然相对较新，但 该中心已经促进了其成员之间的互动，导致了几个正在开发的研究项目，包括胰腺癌、基因组不稳定和干细胞生物学等。此外，此应用程序还包括9个共享研究资源；6个基于BCM现有的强大能力；3个(生物统计学、临床试验支持单位以及病理学和组织银行)，由BCMCC领导和/或资金创建。该中心还设立了外联和健康差距办公室，以更好地将我们在这一领域的广泛研究专门知识转化为我们在TMC和该区域的合作伙伴和同事之间更协调的社区行动。最后，BCMCC最近从一个美好的休斯顿家庭得到了1亿美元的慈善礼物。这笔捐赠完全是为了支持中心、其项目及其成员的发展，并促进与其他机构的合作。即使设立了长期捐赠基金以确保未来的稳定，明年仍将有大量资金可供使用。因此，CCSG概述了组织结构、杰出的领导、综合的科学研究计划、专家共享资源、社区外展的过程、充足和多样化的患者资源以及建立杰出的NCI指定的机构支持 这将使休斯顿社区和地区受益。

DESCRIPTION (provided by applicant): This is the initial application of the Baylor College of Medicine Cancer Center (BCMCC) for NCI designation and is being submitted in the 3rd year of an NCI P20 planning grant. Baylor College of Medicine (BCM) is located in the Texas Medical Center (TMC) in Houston, the largest and perhaps most complex medical center in the country with 40 member institutions. Houston is the 4th largest city in the US with a very diverse population. The BCMCC is a consortium cancer center with BCM as the lead partner, and our four hospital affiliates, Texas Children's Hospital, St. Luke's Episcopal Hospital, The DeBakey Veterans Affairs Medical Center, and Ben Taub General Hospital, as formal clinical partners. In addition, as part of a BCM strategy to create its own ambulatory care facilities, the BCMCC is leading the planning for a comprehensive multidisciplinary cancer clinic to be completed in 2008. The BCMCC was formally established in 2002 to integrate the already strong and organized scientific and clinical programs at BCM and our partners, and to create new synergies and programs that take advantage of this unique environment. The unique environment of the TMC creates many opportunities for scientific, clinical, and educational collaborations, of which the BCMCC takes full advantage. The BCMCC has been given the resources and authority to be successful at this task and has made exciting progress over the past three years. It now includes over 260 formal members, and total annual cancer-relevant research funding documented in this proposal approaches $100 million, with close to $40 million coming from the NCI. The 8 research and translational Programs that were organized through the P-20 process remain in place and are growing stronger. These Programs are Cancer Biology, Molecular Carcinogenesis, Nuclear Receptors, Breast Cancer, Cancer Cell and Gene Therapy, Prostate Cancer, Cancer Prevention, and Pediatric Cancer. In addition, although relatively new, the Center has already fostered interactions among its members that have led to several developing research programs including pancreas cancer, genomic instability, and stem cell biology among others. In addition 9 Shared Research Resources are included in this application; 6 based on strong-capabilities present at BCM, and 3 (Biostatistics, the Clinical Trials Support Unit, and Pathology and Tissue Banking), created through BCMCC leadership and/or funding. The Center has also established an Office of Outreach and Health Disparities to better translate our extensive research expertise in this area into more coordinated community action among our partners and colleagues in the TMC and the region. Finally, the BCMCC has been recently blessed with a $100 million philanthropic gift from a wonderful Houston family. This gift has been entirely dedicated to support the development of the Center, its programs and its members and to foster collaboration with other institutions. Substantial funds will be available for use in the next year even as a long term endowment is created to ensure future stability. Thus, the CCSG outlines an organizational structure, outstanding leadership, integrated scientific research programs, expert Shared Resources, a process for community outreach, adequate and diverse patient resources, and the institutional support to build an outstanding NCI-designated Cancer Center that will benefit the Houston Community and region.