Interdisciplinary Research in Mental Retardation

精神发育迟滞的跨学科研究

• 批准号: 7931446
• 负责人: WILLIAM J MCILVANE
• 金额: $ 7.5万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7931446
• 关键词: Interdisciplinary; Research; Mental; Retardation

DESCRIPTION (provided by applicant): Fundamental issues both within and beyond biology are how the brain develops and how its interactions with the environment influence behavior. The Developmental Disabilities Research Center (DDRC) at the University of Massachusetts Medical School (UMMS) addresses these issues through wide-ranging programs of research on typical and atypical development, which include biomedical, biobehavioral, behavioral, and social science dimensions. Specific focus areas include developmental neuroscience, genetics of neurodevelopmental disorders, sensory systems and information processing, behavioral and cognitive neuroscience, cognitive psychology and behavior analysis, and social process and policy analysis. The DDRC and its companion University Center for Excellence in Developmental Disabilities (UCEDD) also train professionals for careers in research and service to people with disabilities and their families. Research interests of the UMMS DDRC include (1) understanding biological processes that occur during development of the nervous system; (2) characterizing molecular defects in genetic disorders which affect the nervous system; (3) establishing the genetic basis of neurodevelopmental disorders, along with potentially related neuropsychiatric and neurodegenerative disorders; (4) identifying brain regions and functional systems that may be involved in MRDD; (5) advancing knowledge of fundamental processes involved in learning, perception, language, and cognition; (6) applying the latter knowledge to improve the educational opportunities for persons with MRDD, and (7) understanding social processes and social policy implications relevant to persons with MRDD and their families. This revised application for MRDDRC funding encompasses a number of new interdisciplinary collaborations among UMMS faculty and programs. Four core units are proposed to encourage further collaborations relevant to the missions of the DDRC and NICHD. The core units are: Administration, Neuroscience Integration and Support, Scientific and Technical Information Services, and Clinical and Translational Research Support. Each core unit features equipment, facilities, and/or problem-solving capability, and each gives quality, cost-effective service to numerous PHS-funded projects. The collective operations of the cores will both enhance existing MRDD research, and stimulate new interdisciplinary and translational research in MRDD at UMMS and its affiliated institutions.

描述（由申请人提供）：生物学内外的基本问题是大脑如何发育以及它与环境的相互作用如何影响行为。 马萨诸塞州大学医学院（UMMS）的发育障碍研究中心（DDRC）通过对典型和非典型发育的广泛研究计划来解决这些问题，其中包括生物医学，生物行为，行为和社会科学方面。 具体的重点领域包括发育神经科学，神经发育障碍的遗传学，感觉系统和信息处理，行为和认知神经科学，认知心理学和行为分析，以及社会过程和政策分析。 DDRC及其同伴大学卓越发展障碍中心（UCEDD）还培训专业人员从事研究和服务残疾人及其家庭的职业。 UMMS DDRC的研究兴趣包括（1）了解神经系统发育过程中发生的生物学过程;（2）表征影响神经系统的遗传性疾病的分子缺陷;（3）建立神经发育障碍的遗传基础，沿着潜在相关的神经精神和神经退行性疾病;（4）识别可能参与MRDD的大脑区域和功能系统;（5）推进学习、感知、语言和认知的基本过程的知识;（6）应用后一种知识来改善MRDD患者的教育机会，（7）了解与MRDD患者及其家庭相关的社会进程和社会政策影响。 修订后的MRDDRC资金申请包括UMMS教师和课程之间的一些新的跨学科合作。 建议设立四个核心单位，以鼓励与发展研究中心和国家排雷中心的任务有关的进一步合作。 核心单位是：管理，神经科学集成和支持，科学和技术信息服务，以及临床和转化研究支持。 每个核心单位都配备了设备、设施和/或解决问题的能力，并为许多公共卫生服务资助的项目提供高质量、高成本效益的服务。 核心的集体运作将加强现有的MRDD研究，并刺激UMMS及其附属机构的MRDD新的跨学科和转化研究。