SHARED INSTRUMENTATION

共享仪器核心的主要目标是提供方案项目工作人员 以方便、协调的方式获取对计划中的 研究计划。这一核心被设计成帮助调查人员应用 这些技术给他们的项目，无论是在建设和分析他们的 计算机化的行为测试方案。核心的眼球跟踪实验室允许在线 测量参与者的凝视点，提供实时直接的可视化。这个 观测编码设施为PO1调查人员提供了高效和灵活的工具 分析录像数据，包括眼球运动记录。电生理学 实验室将协助研究人员评估神经生理学与 在行为研究、范例方面的表现，包括对 感官功能。最后，核心将与P30支持的MRDDRC协调活动 以支持广泛的计算机化行为测试设备，该设备几乎驱动所有 在计划项目中收集行为数据。 参与项目的人员，包括顾问/合作者。根据需要使用续页 以以下所示格式提供所有参与该项目的个人的必要信息。 主要研究员：特蕾莎·米切尔，密歇根州立大学施莱弗中心精神病学助理教授 联合首席研究员：迈克尔·卡林，密歇根州立大学施莱弗中心精神病学助理教授 第265页 智力低下患者的刺激控制研究。 核心B：Mitchell&Carlin 1.目标和背景 共享仪器核心的主要目标是为方案项目工作人员提供 方便、协调地访问多个方法，这些方法对于 研究项目。我们设计了核心B，以帮助调查人员有效地利用 这些方法论。核心的主要功能是与P30支持的MRDDRC接口 (见一般资源一节)在其职责范围内。MRDDRC科学部 通信和技术信息服务核心将共享运营和财务 负责开发和提供支持行为测试所需的软件 协议。P01共享仪器内核还将提供不能提供的补充服务 目前由P30赠款直接支持，将： &gt；允许调查人员直接在线测量眼球运动 参与者的实时表演(眼球跟踪实验室)； &gt；促进对录像行为的评分(观察编码设施)；以及 &gt；允许测量大脑事件相关电位(ERPs)以应对在 行为测试(电生理学实验室)。 在促进眼球跟踪和电生理实验室内的研究方面，P01分享了 仪器核心还将与MRDDRC临床和翻译研究支持对接 核心。除参与者招募职能外，复员方案核心还将协助 让学员做好准备，获得高质量的录音(见下文)。 2.专业和辅助人员 核心将由特蕾莎·米切尔博士(10%的努力)和迈克尔·卡林(10%的努力)共同执导， 并由兼职研究技术人员提供支持(每人20%的努力)。卡林博士有足够的 学习视觉搜索所使用的自动化测试协议的经验(项目1和2) 和歧视表演(所有项目)。此外，他还拥有使用 眼睛跟踪方法(项目1-3)。 米切尔博士是一位经验丰富的电生理学家，他领导着一家最先进的研究机构(参见 有关施莱弗中心的描述，请参阅下面的资源和常规资源部分 电生理设施)。此外，她现在正在与MRDDRC核心的工作人员合作 调整演示软件包(神经行为系统)-在她自己的演讲中广泛使用 在此处建议的项目类型中使用。 3.行政和运作 与MRDDRC对接。如上所述，共享仪器核心将在 与解除武装、复员和重返社会委员会进行协商和协调。界面的两个点对于 本计划项目： 第一个接口点是与MRDDRC科学通信和技术中心 信息服务核心单位，具体地说是一个子组成部分--科学仪器和 计算机编程单元--由William Dube博士指导。这项服务提供 咨询和直接服务于需要协助的调查人员 实验室，特别是在计算机应用方面。 计算机化的生物行为和行为实验室需要持续的维护和 定期需要定制计算机编程，以用于设备控制和 数据分析。计算机编程通常在两个层面上进行。源代码编程 是实现新功能或过程所必需的；必须完成这样的编程 由一位熟悉编程语言的专家编写，这种语言可以编译成机器- 可读代码(例如，Visual Basic、C++)。这一过程需要程序规范、生产、 测试、安装和文档。应用程序级编程通常是完成的 第266页

The primary objective of the Shared Instrumentation core is to provide program project staff with convenient, coordinated access to technologies that are essential to the proposed programs of research. This core has been designed to assist investigators in the application of these technologies to their projects, both in the construction and analysis of their computerized behavioral testing protocols. The core's Eyetracking Laboratory allows on-line measurement of participants' point of gaze, affording direct visualization in real time. The Observational Coding facility provides tools for PO1 investigators to efficiently and flexibly analyze videotaped data, including eye movement records. The Electrophysiological Laboratories will assist investigators in assessment of neurophysiological correlates of performances on behavioral research,paradigms, including assessment of the integrity of sensory functions. Finally, the core will coordinate activity with the P30-supported MRDDRC in support of the extensive computerized behavioral testing apparatus that drives virtually all behavioral data collection in the program project. PERSONNEL ENGAGED ON PROJECT, INCLUDING CONSULTANTS/COLLABORATORS. Use continuation pages asneeded to provide the required information in the format shown below on all individuals participating in the project. Principal Investigator: Teresa Mitchell, Assistant Professor of Psychiatry, UMMS Shriver Center Co-Principal Investigator: Michael Carlin, Assistant Professor of Psychiatry, UMMS Shriver Center Page 265 Studies of Stimulus Control in Mental Retardation William J. Mcllvane, Ph.D. Core B: Mitchell & Carlin 1. Objective and Background The primary objective of the Shared Instrument core is to provide program project staff with convenient, coordinated access to several methodologies that are essential to the proposed research programs. We have designed Core B to assist investigators in making effective use of these methodologies. A major function of the core is to interface with the P30-supported MRDDRC (see general Resources section) within its areas of responsibility. The MRDDRC Scientific Communications and Technical Information Services core will share operational and financial responsibility for developing and providing the software necessary to support the behavioral testing protocols. The P01 Shared Instrument core will also provide complementary services that are not presently supported directly by P30 grant which will: > allow investigators to perform direct on-line measurement of eye movements during participants' performances, in real time (the Eyetracking Laboratory); > facilitate the scoring of videotaped behavior (the Observational Coding Facility); and > permit measurement of brain event-related potentials (ERPs) to stimuli presented during behavioral testing (Electrophysiology Laboratories). In facilitating research within the Eyetracking and Electrophysiology laboratories, the P01 Shared Instrument core will interface also with the MRDDRC Clinical and Translational Research Support core. In addition to the participant recruiting function, the MRDDRC core will also assist in the preparation of participants to obtain quality recordings (see below). 2. Professional and Support Staff The core will be co-directed by Drs. Teresa Mitchell (10% effort) and Michael Carlin (10% effort), and each supported by part-time research technicians (each 20% effort). Dr. Carlin has ample experience with the automated test protocols that are used to study visual search (Projects 1 and 2) and discrimination performances (all projects). In addition, he has experience in the use of eyetracking methodologies (Projects 1-3). Dr. Mitchell is an experienced electrophysiologist, who directs a state-of-the-art research facility (see Resources below and the general Resources section for a description of the Shriver Center's electrophysiology facilities). In addition, she is now working with the staff of the MRDDRC core to adapt the Presentation software package (Neurobehavioral Systems) - used extensively in her own work  for use in the types of projects proposed here. 3. Administration and Operations Interface with the MRDDRC. As noted above, the Shared Instrument Core will operate in consultation and coordination with the MRDDRC. Two points of interface are most important for this program project: The first point of interface is with the MRDDRC Scientific Communications and Technical Information Services core unit, specifically a subcomponent - the Scientific Instrumentation and Computer Programming unit - that is directed by Dr.William Dube. This service provides consultation and direct service to investigators who require assistance in instrumentation of their laboratories, particularly with regard to computer applications. Computerized biobehavioral and behavioral laboratories require ongoing maintenance and periodically require custom computer programming for applications such as equipment control and data analysis. Computer programming often takes place at two levels. Source-code programming is necessary to implement new functions or procedures; such programming must be accomplished by an expert familiar with a programming language that can be compiled to produce machine- readable code (e.g., Visual Basic, C++). This process requires program specification, production, testing, installation, and documentation. Applications-level programming is routinely accomplished Page 266