Neuroscience Integration & Support

神经科学集成与支持核心 订正提案介绍 正如前面在应用程序中提到的，我们2002年的提案有两个服务核心， 神经生物学项目对这两个核心的审查似乎贯穿四个关切领域， 而这些担忧导致了两者的平庸评级（核心B：212，核心C：200）。这些关切是： (a)核心单元在概念上和程序上需要更大的差异。 (b)一些核心组成部分被认为比其他组成部分强得多; (c)某些后勤方面需要进一步解释; (d)某些工作人员的资格要求更多的文件。 作为回应，我们重新思考了提出两个神经生物学核心的理由。最终我们 我的结论是，如果将两者结合起来，我们可以提出一个更强有力的建议： 那些被认为不那么引人注目的，增加了将增强核心能力的组成部分， 形成了一个比较全面的综合核心概念。正如修订后的建议所阐明的，我们 提供概念上的综合服务菜单，代表从基因/蛋白质 神经生物学的发现对更大的神经系统的神经生物学结构和功能的研究。 尽管在上一份申请中提出的核心组成部分与 这一点，我们认为，目前的建议是一个大大改善，更好地阐述，更 成熟的建议-实际上是一个新的建议。它无疑代表了一个新的核心概念。因为 变化是如此广泛，我们认为，指出保留的文本段落将更多 对我们的评论者来说，困惑多于帮助。以下内容总结了已经发生的主要变化， 加强我们的MRDDRC提案。

NEUROSCIENCE INTEGRATION & SUPPORT CORE Introduction to the Revised Proposal As noted earlier in the application, our 2002 proposal had two service cores supporting basic neurobiology programs. Four areas of concern appeared to cut across the review of these two cores, and these concerns led to mediocre ratings for both (Core B: 212, Core C: 200). The concerns were: (a) The cores units required greater differentiation conceptually and programmatically. (b) Some core components were judged substantially stronger than others; (c) Certain logistical aspects required further explanation; (d) Certain staff qualifications required more documentation. In response, we rethought the rationale for proposing two neurobiology cores. Ultimately, we concluded that we could make a stronger proposal if the two were combined: We removed components that were judged less compelling, added components that would enhance the core capabilities, and developed a more comprehensive integrative core concept. As the revised proposal will articulate, we offer a conceptually integrated menu of services that represent a progression from gene/protein discovery to the study of the neurobiological structure and function of larger neural systems. Although there is overlap between core components that were proposed in the last application and in this one, we believe that the present proposal is a vastly improved, much better articulated, more mature proposal - virtually a new proposal. It certainly represents a new core concept. Because the changes are so extensive, we thought that indicating text passages that were retained would be more confusing than helpful for our reviewers. What follows summarizes the major changes that have been made to strengthen our MRDDRC proposal.