Univ. of Miami Comprehensive Sickle Cell Center: Basic & Translational Research

大学。

• 批准号: 7636762
• 负责人: Floyd Daniel Armstrong
• 金额: $ 55.26万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-15 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7636762
• 关键词: Univ.; Miami; Comprehensive; Sickle; Cell

DESCRIPTION (provided by applicant): The aims of this Comprehensive Sickle Cell Center are to (1) establish a research center that promotes collaboration to conduct clinical trials in clinical research in sickle cell disease; (2) rapidly advance access to effective treatment by participating in multi-center Phase II and high-risk clinical trials; (3) improve access to quality sickle cell care throughout the region through the implementation of strong clinical and patient services cores, (4) carry out clinical, patient services, and translation research studies in advance knowledge about the treatment of sickle cell disease, and (5) contribute to the future workforce of professionals who are able to conduct research and provide high-quality service to patients with sickle cell. We will establish (a) collaborative relationships with other programs to provide services to children and adults with sickle cell disease for the purpose of conducting research and disseminating information to the community; (b) a clinical core and will provide the necessary infrastructure for participating in clinical research, and will provide a common resource for assessing stroke risk for all participants in our studies; and (c) a patient services core that will enhance the capacity and outcomes of the newborn screening program, provide just-in-time information about sickle cell disease on the Internet to the community that interacts with individuals with sickle cell disease, and improve continuity of care by establishing a transition program between adolescent and young adult care. We will conduct (a) a clinical research study that focuses on safety and effectiveness of bosenten in the treatment of sickle pain, (b) a patient services research study evaluating an intervention to improve academic achievement, reduce family conflict, and improve health status, and (c) a translational study evaluating the role hypoxia on brain development and the application of this information to an intervention using oxygen supplementation to improve cognitive function in children with chronic hypoxia. We will also establish a training program in sickle cell disease for doctoral-level professionals, and promote careers in sickle cell disease through a high school summer program. This will all be accomplished by an integrated team of basic, clinical, and behavioral scientist working at the University of Miami and in collaboration with other centers. The public health benefit of this project will be improved access to knowledge, new approaches to care, and opportunities to advance knowledge by participation in research.

描述（由申请人提供）： 该综合性镰状细胞病中心的目标是：（1）建立一个促进合作的研究中心，在镰状细胞病的临床研究中进行临床试验;（2）通过参与多中心II期和高风险临床试验，快速推进有效治疗的获得;（3）通过实施强有力的临床和患者服务核心，改善整个地区获得高质量镰状细胞病护理的机会，（4）开展临床和患者服务，和翻译研究的研究，提前了解有关治疗镰状细胞病，和（5）有助于未来的专业人员谁能够进行研究，并提供高质量的服务，镰状细胞患者。我们将建立（a）与其他项目的合作关系，为患有镰状细胞病的儿童和成人提供服务，以便开展研究并向社区传播信息;（B）临床核心，并将为参与临床研究提供必要的基础设施，并将为我们研究的所有参与者提供评估中风风险的公共资源;以及（c）一个病人服务核心，将提高新生儿筛查计划的能力和结果，在互联网上向与镰状细胞病患者互动的社区提供及时的镰状细胞病信息，并通过建立青少年和年轻成人护理之间的过渡计划来改善护理的连续性。我们将进行（a）一项临床研究，重点是bosenten治疗镰状疼痛的安全性和有效性，（B）一项患者服务研究，评估一种干预措施，以提高学业成绩，减少家庭冲突，改善健康状况，以及（c）一项转化研究，评估缺氧对大脑发育的作用，并将此信息应用于氧气补充干预改善慢性缺氧儿童的认知功能。我们还将为医生级专业人员建立镰状细胞病培训计划，并通过高中暑期课程促进镰状细胞病的职业发展。这一切都将由一个综合团队完成的基础，临床和行为科学家在迈阿密大学工作，并与其他中心合作。该项目的公共卫生效益将是改善获得知识的机会，新的护理方法，以及通过参与研究来促进知识的机会。