Early Caries Detection with Near-IR Light

使用近红外光进行早期龋齿检测

• 批准号: 7795217
• 负责人: Daniel Fried
• 金额: $ 32.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795217
• 关键词: Anti-Bacterial Agents; Biological Preservation; Clinic; Clinical; Clinical Research; Clinical Trials; Data; Dental; Dental Enamel; Dental caries; Dentin; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic radiologic examination; Early Diagnosis; Elements; Fiber; Fluorides; Future; Gel; Gold; Hand; Histology; Image; Imaging technology; In Vitro; Indium; Intervention; Investigation; Ionizing radiation; Lasers; Lesion; Light; Measures; Microradiography; Molar tooth; Monitor; Nonionizing Radiation; Operating System; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Patients; Pediatric Dentistry; Penetration; Performance; Phase; Polarization Microscopy; Research; Research Personnel; Scanning; Schedule; Secondary Lesion; Severities; Specimen; Staging; Structure; Surface; System; Technology; Testing; Time; Tissues; Tooth structure; Water; absorption; attenuation; cost; deciduous tooth; digital; gallium arsenide; imaging modality; in vivo; indexing; irradiation; light scattering; light transmission; new technology; novel; optical imaging; programs; prototype; restoration; sound; success; tool; transmission process; wisdom tooth

DESCRIPTION (provided by applicant): The overall objective of the proposed research is to develop non-invasive optical devices for the detection and diagnosis of early Dental caries (dental decay). New, more sophisticated diagnostic tools are needed for the detection and characterization of caries lesions in the early stages of development. If carious lesions are detected early enough, they can be arrested/reversed by non-surgical means through fluoride therapy, anti- bacterial therapy, dietary changes, or by low intensity laser irradiation. The principal factor limiting optical imaging through the enamel of the tooth in the visible range of 400-700-nm is light scattering. Light scattering in sound enamel and dentin is sufficiently strong in the visible range to obscure light transmission through the tooth. The magnitude of light scattering in Dental enamel decreases markedly with increasing wavelength. Therefore, we posit that the near-IR region at 1310-nm offers the greatest potential for new optical imaging modalities due to the weak scattering and absorption in sound Dental hard tissue. At longer wavelengths, absorption of water in the tissue increases markedly reducing the penetration of IR light. The overall objective of this application will be achieved through the following Specific Aims: 1) to test the hypothesis that near-IR polarization-sensitive optical coherence tomography (PS-OCT) can be used for the accurate assessment of the depth and severity of natural occlusal lesions in vivo. 2) To test the hypothesis that a near-IR (NIR) imaging system operating at 1310-nm can be used to acquire high-contrast images of interproximal and occlusal caries lesions in vivo. It is likely that if these studies and future clinical trials are a success, that these novel technologies for imaging Dental hard tissue will be employed for the detection and monitoring of early carious lesions without the use of ionizing radiation, thereby enabling conservative non- surgical intervention and the preservation of healthy tissue structure. Moreover, it is probable that this proposed imaging technology would enable the clinician to detect and quantify the severity of occlusal lesions that are not resolvable with conventional radiography due to the surrounding sound tissue structure.

描述(申请人提供)：拟议研究的总体目标是开发用于检测和诊断早期龋齿(龋齿)的非侵入性光学设备。在发育的早期阶段，需要新的、更复杂的诊断工具来检测和描述龋损。如果及早发现龋损，可以通过氟化物治疗、抗菌治疗、改变饮食或低强度激光照射等非手术手段来阻止/逆转龋损。限制通过牙釉质的光学成像在400-700纳米可见光范围内的主要因素是光散射。声音、牙釉质和牙本质中的光散射在可见光范围内足够强，从而遮挡了通过牙齿的光传输。随着波长的增加，牙釉质中的光散射强度明显减小。因此，我们假设1310 nm处的近红外区域由于牙科硬组织的弱散射和吸收而为新的光学成像方式提供了最大的潜力。在较长的波长下，组织对水的吸收显著增加，减少了对红外光的穿透。这项应用的总体目标将通过以下具体目标来实现：1)验证近红外偏振敏感光学相干断层扫描(PS-OCT)可用于在体准确评估天然咬合病变的深度和严重程度的假设。2)验证1310 nm的近红外(NIR)成像系统可用于活体获取邻面和咬合间龋损的高对比度图像的假设。如果这些研究和未来的临床试验取得成功，这些新的牙科硬组织成像技术将被用于检测和监测早期龋齿病变，而不使用电离辐射，从而能够进行保守的非手术干预和保存健康的组织结构。此外，这项拟议的成像技术很可能使临床医生能够检测和量化由于周围健全的组织结构而无法用传统放射学解决的咬合病变的严重程度。