Optical Methods for Lesion Activity Assessment

病变活动评估的光学方法

• 批准号: 9769674
• 负责人: Daniel Fried
• 金额: $ 38.12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769674
• 关键词: Air; Chemicals; Clinical Management; Clinical Markers; Clinical Research; Clinical assessments; Custom; Dehydration; Dental Cavity Preparation; Dental caries; Development; Diagnosis; Dimensions; Effectiveness; Fissural; Fluorides; Hand; Image; Imaging technology; In Vitro; Intervention; Lesion; Measurable; Measurement; Measures; Methods; Microradiography; Minerals; Mission; Monitor; National Institute of Dental and Craniofacial Research; Nonionizing Radiation; Optical Methods; Optics; Plant Roots; Polarization Microscopy; Population; Porosity; Public Health; Research; Root Caries; Severities; Stains; Structure; Surface; Testing; Therapeutic Intervention; Thick; Time; Tissues; Tooth structure; clinical decision-making; contrast imaging; deciduous tooth; demineralization; design; imaging modality; improved; in vivo; light scattering; novel diagnostics; preservation; remineralization; restoration; success; tool

ABSTRACT The overall objective of this proposed research is to develop methods for the clinical assessment of lesion structure and activity. New imaging technologies employing non- ionizing radiation are needed to aid in caries diagnosis and management. It is not sufficient to simply detect caries lesions, methods are needed to assess the lesion activity and determine if chemical intervention is needed. Measurements of lesion structure and the optical and dimensional changes to lesions that occur during dehydration offer the potential for lesion activity assessment during a single examination. The central hypothesis underlying this proposal is that there are structural differences between active and arrested lesions and these differences can be quantified using near- IR (NIR) imaging methods. The objectives of this proposal will be achieved through the following specific aims: (1) To test the hypothesis that NIR reflectance measurements during lesion dehydration are more sensitive to changes in lesion structure and activity than existing methods and that NIR imaging can be used to assess the activity of coronal caries lesions in vivo. (2) To test the hypothesis that cross-polarization OCT (CP-OCT) can be used to assess changes in lesion structure and activity in the pits and fissures of primary teeth before and after chemical intervention. (3) To test the hypothesis that CP-OCT can be used to assess the activity of lesions on root surfaces and monitor the efficacy of conservative intervention in vivo. Success of this proposal will provide methods for assessing the activity of lesions in a single examination and for monitoring the efficacy of chemical intervention, thereby enabling the use of new intervention therapies to avert cavitation and restoration.

摘要 这项拟议研究的总体目标是开发用于临床的方法， 评估病变结构和活性。新的成像技术采用非 需要电离辐射来帮助龋齿诊断和处理。不 足以简单地检测龋齿损伤，需要评估损伤的方法 活动，并确定是否需要化学干预。病变测量 结构和光学和尺寸的变化，发生病变， 脱水提供了在单次检查中评估病变活动性的可能性。 这一提议的核心假设是， 活动性和停滞病变之间的差异，这些差异可以量化使用近- IR（NIR）成像方法。本提案的目标将通过以下方式实现： 以下具体目的：（1）检验近红外反射率测量的假设， 在病变脱水更敏感的病变结构和活动的变化 比现有的方法，近红外成像可以用来评估活动， 体内冠龋病变。(2)为了检验交叉偏振OCT （CP-OCT）可用于评估病变结构的变化和小凹中的活动， 乳牙化学干预前后的裂隙。(3)测试 假设CP-OCT可用于评估牙根表面病变的活动性 并在体内监测保守干预的疗效。 这项建议的成功将提供评估方法的活动，病变在一个 单次检查和监测化学干预的功效，从而 使得能够使用新的介入疗法来避免气穴和恢复。