Functional Remapping of Hand Control

手动控制的功能重新映射

• 批准号: 7916579
• 负责人: FERDINANDO Alessandro MUSSA-IVALDI
• 金额: $ 40.32万
• 依托单位: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916579
• 关键词: Activities of Daily Living; Address; Anterior; Behavior; Behavioral; Collaborations; Complex; Computational Technique; Computers; Data; Data Analyses; Devices; Dimensions; Disabled Persons; Disease; Dorsal; Exposure to; Feedback; Fingers; Freedom; Functional Imaging; Gestures; Goals; Hand; Human; Image Analysis; Injury; Knowledge; Lead; Learning; Limb structure; Location; Manuals; Maps; Mechanics; Methods; Monitor; Motion; Motor; Movement; Muscle; Musculoskeletal; Nervous system structure; Organ; Outcome; Parietal; Patients; Pattern; Performance; Plastics; Population; Positioning Attribute; Posture; Powered wheelchair; Principal Component Analysis; Process; Property; Records; Recovery; Rehabilitation therapy; Relative (related person); Research; Research Personnel; Role; Self-Help Devices; Series; Shapes; Side; Signal Transduction; Solid; Spinal cord injury; Stroke; Structure; System; Techniques; Testing; Therapeutic Intervention; Training; Training Support; Water; arm; base; behavior observation; brain machine interface; design; disability; flexibility; grasp; human subject; independent component analysis; instrument; motor control; motor learning; neuroimaging; neuromechanism; novel; programs; prototype; public health relevance; relating to nervous system; research study; skills; two-dimensional; visual feedback

DESCRIPTION (provided by applicant): The purpose of this project is to develop a deeper understanding of the mechanisms that allow reorganization of motor functions, and to identify means of exploiting these adaptive mechanisms to facilitate training of novel hand movements. Movement reorganization is needed to compensate for disability as well in normal daily activities, for example when one learns to operate a new vehicle. These studies will use and expand a novel, non-invasive paradigm to investigate the behavioral, neural and computational mechanisms for remapping of motor functions. This paradigm has been developed by the PI and the two co-investigators in a set of preliminary studies. Subjects wear an instrumented data glove that records the angular motions of the fingers. The signals generated by the glove operate a remotely-controlled endpoint - such as a cursor on a computer screen. Subjects are instructed to execute movements of this endpoint with controlled motions of the fingers. The overarching question addressed through this new paradigm concerns the representation of motor space - the space in which the controlled actions take place. How flexible, or "plastic", is this representation and what is its relation to the space of motor control signals? The studies are organized in three specific aims: Aim 1: To investigate the formation of new coordinated hand movements for the control of a low- dimensional device Aim 2: To test the adaptive neural representations for reaching and grasping. Aim 3: To facilitate the learning of new motor maps for hand movements The expected outcomes will likely lead to more successful human-machine interactions and rehabilitation techniques for the disabled by identifying ways of selectively enhancing task-relevant visual feedback in order to better promote desired movement features, including more highly-individuated finger movements. PUBLIC HEALTH RELEVANCE This proposal is directed at understanding the mechanisms underlying the reorganization of motor functions and motor coordination through a combination of behavioral observations, functional neuroimaging and computational techniques. It is expected that this study will identify new means for exploiting the ability of the nervous system to reorganize itself so as to facilitate training novel hand movements and to recover skills lost to stroke and other neuromotor disorders

描述（由申请人提供）：本项目的目的是发展一个更深入的了解机制，允许重组的运动功能，并确定利用这些自适应机制，以促进新的手部动作的训练手段。运动重组是必要的，以弥补残疾以及在正常的日常活动，例如，当一个人学习操作一辆新车。这些研究将使用并扩展一种新的非侵入性范式，以研究重新映射运动功能的行为，神经和计算机制。PI和两名合作研究者在一系列初步研究中开发了这种范式。受试者戴着一个仪器数据手套，记录手指的角运动。手套产生的信号操作一个远程控制的端点--比如电脑屏幕上的光标。指导受试者通过手指的受控运动来执行该终点的运动。通过这种新范式解决的首要问题涉及运动空间的表征-受控动作发生的空间。这种表现有多灵活或“可塑性”，它与运动控制信号的空间有什么关系？这些研究被组织在三个特定的目标：目标1：研究形成新的协调的手运动的控制的低维设备目标2：测试的自适应神经表征达到和把握。目标3：为了促进手部运动的新运动地图的学习，预期的结果可能会导致更成功的人机交互和康复技术的残疾人通过识别的方式选择性地增强任务相关的视觉反馈，以更好地促进所需的运动功能，包括更高度个性化的手指运动。公共卫生相关性本提案旨在通过行为观察、功能性神经成像和计算技术的结合，了解运动功能重组和运动协调的潜在机制。预计这项研究将确定新的手段，利用神经系统的能力，重组本身，以促进训练新的手部动作和恢复技能失去了中风和其他神经运动障碍

项目成果

Dataglove measurement of joint angles in sign language handshapes.

• DOI: 10.1075/sll.15.1.03ecc
• 发表时间: 2012
• 期刊: Sign language and linguistics
• 影响因子: 0.8
• 作者: Eccarius P;Bour R;Scheidt RA
• 通讯作者: Scheidt RA

Sensory motor remapping of space in human-machine interfaces.

人机界面中空间的感觉运动重新映射。

• DOI: 10.1016/b978-0-444-53752-2.00014-x
• 发表时间: 2011
• 期刊: Progress in brain research
• 作者: Mussa-Ivaldi,FerdinandoA;Casadio,Maura;Danziger,ZacharyC;Mosier,KristineM;Scheidt,RobertA
• 通讯作者: Scheidt,RobertA

The influence of visual motion on motor learning.

• DOI: 10.1523/jneurosci.5528-11.2012
• 发表时间: 2012-07-18
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Danziger Z;Mussa-Ivaldi FA
• 通讯作者: Mussa-Ivaldi FA

The body-machine interface: a new perspective on an old theme.

• DOI: 10.1080/00222895.2012.700968
• 发表时间: 2012
• 期刊: Journal of motor behavior
• 影响因子: 1.4
• 作者: Casadio M;Ranganathan R;Mussa-Ivaldi FA
• 通讯作者: Mussa-Ivaldi FA