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Visuospatial Function in Parkinson's Disease

帕金森病的视觉空间功能

基本信息

批准号：
7799913
负责人：
Alice Cronin-Golomb
金额：
$ 40.75万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-01 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7799913
关键词：
Adult Affect Age Alzheimer&apos s Disease Area Attention Basal Ganglia Brain Cognition Cognitive Comprehension Contralateral Contrast Sensitivity Detection Disease Elderly Emotional Ensure Environment Exhibits Frequencies Functional disorder Gait Health Professional Impairment Individual Lateral Lead Left Light Link Literature Measures Motion Motor NIH Program Announcements National Institute of Neurological Disorders and Stroke Nerve Degeneration Neurodegenerative Disorders Neuropsychological Tests Optical Coherence Tomography Optics Parietal Parkinson Disease Participant Patient Self-Report Patients Pattern Performance Population Problem Solving Quality of life Questionnaires Reporting Research Retinal Side Signal Transduction Source Subgroup Symptoms System Technology Testing Time Translational Research United States National Institutes of Health Vision Vision Tests Visual Visual Fields Visuospatial age related clinically relevant cognitive change cognitive function cognitive neuroscience daily functioning executive function follow-up innovation motor impairment normal aging retinal nerve fiber layer spatial vision standardize measure visual cognition visual process visual processing young adult

项目摘要

Parkinson's disease (PD) is a common age-related neurodegenerative disorder in which multiple aspects of visuospatial cognitive function are impaired. Spatial dysfunction arises from pathological changes in high- order association areas of the brain but also from defective input from lower-level visual processingareas. Deficits in vision are prevalent in PD but virtually nothing is known about the relation between vision, cognition, and daily function in this disorder. Also unknown are the cognitive sequelae of the side of initial motor impairment, despite PD nearly always having unilateral onset of neurodegeneration and unequivocal evidence linking spatial abnormalities to right-hemisphere dysfunction. We propose a multi-level approach to examining visuospatial dysfunction in PD. One major focus is on the visuospatial consequencesof visual deficits, specifically the reduced signal strength that results from contrast sensitivity loss. An innovative aspect of the study is our use of frequency doubling technology and optical coherence tomographyto assess visual (including retinal) function. A second focus is on the side of onset of motor impairment, contralateral o the hemisphere with predominant basal ganglia dysfunction. We plan to conduct control tests of motor- system and prefrontal function to ascertain the extent of independence of the occipital and parietal areas in affecting spatial function in PD. Further, we will conduct an exploration of the relation of visual and visuospatial impairments to daily function as assessed through self-report questionnaires and with an objective open-field measure of gait curvature. Assessmentwill occur at baseline and at one-year follow-up. We propose to examine the ability of 36 patients with left-onset PD (LPD), 36 with right-onset PD (RPD), 36 healthy age-matched adults, and 36 healthy young adults to perform on tests of vision and visuospatial function. Individuals with PD will likely exhibit poorer performance on most tests of vision and visuospatial function than age-matched adults, who in turn will exhibit poorer performance than young adults. We further expect that LPD will show more extensive visuospatial impairments than RPD, and that the pattern of impairments will distinguish the two subgroups. Our tests target visual and visuospatial symptoms reported by the patients themselves, ensuring that the elucidation of mechanisms will have clinical relevance. Demonstration of different profiles of performance in LPD and RPD would bolster arguments of selective visuospatial deficits in PD and suggest differential visual, cognitive, and functional enhancement strategies.

帕金森病（PD）是一种常见的与年龄相关的神经退行性疾病

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Parkinson's disease as a disconnection syndrome.

DOI：
10.1007/s11065-010-9128-8
发表时间：
2010-06
期刊：
NEUROPSYCHOLOGY REVIEW
影响因子：
5.8
作者：
Cronin-Golomb, Alice
通讯作者：
Cronin-Golomb, Alice

Visuospatial perception and navigation in Parkinson's disease.

DOI：
10.1016/j.visres.2010.08.029
发表时间：
2010-11-23
期刊：
VISION RESEARCH
影响因子：
1.8
作者：
Young, Daniel E.;Wagenaar, Robert C.;Lin, Cheng-Chieh;Chou, Ying-Hui;Davidsdottir, Sigurros;Saltzman, Elliot;Cronin-Golomb, Alice
通讯作者：
Cronin-Golomb, Alice

Web-based assessment of visual and visuospatial symptoms in Parkinson's disease.