IMMUNOGENETICS AND FUNCTIONAL RESPONSE TO TYPE A INFLUENZA STRAINS

A 型流感病毒株的免疫遗传学和功能反应

• 批准号: 7960085
• 负责人: JONATHAN RUNSTADLER
• 金额: $ 21.33万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960085
• 关键词: Alaska; Alopex; Avian Influenza; Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Disease; Ecology; Environment; Funding; Genes; Genetic; Grant; Health; Immune; Immunogenetics; Infection; Influenza; Influenza A Virus, H5N1 Subtype; Institution; Rabies; Research; Research Personnel; Resources; Running; Sampling; Source; Type A Influenza; United States National Institutes of Health; environmental agent; response; wild bird

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research The arctic fox and rabies infection remains an attractive project, however, my lab currently remains very focused on avian influenza. I have two parts of this project running and two in development: 1) Avian influenza  surveillance for avian influenza in Alaska. This multiyear effort will serve as baseline data for collaborative projects to understand the emergence and ecology of avian influenza in the natural environment and in reservoir hosts. a. Summary of 900 2005 samples analyzed to date - 25% positive, 5 subtypes, no H5N1 2) Environmental samples  correlation of influenza in birds with influenza positives in the environment. a. 9 of 11 samples analyzed show matrix and np positives In development: 1) Immunogenetic studies in wild birds: Genetic characterization of immune relevant genes. 2) Functional assays of immune health

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究 北极狐和狂犬病感染仍然是一个有吸引力的项目，然而，我的实验室目前仍然非常专注于禽流感。 我有这个项目的两个部分运行和两个在开发中： 第一章 禽流感  阿拉斯加禽流感监测。 这项多年的努力将作为合作项目的基线数据，以了解自然环境和水库宿主中禽流感的出现和生态。 a. 迄今为止分析的900份2005年样本摘要----25%阳性，5种亚型，无H5N1 （二） 环境样品  禽流感与环境中流感阳性的相关性。 a. 分析的11份样品中有9份显示基质和np阳性 正在开发： 第一章 野生鸟类的免疫遗传学研究： 免疫相关基因的遗传特征。 （二） 免疫健康的功能测定