Deep brain stimulation of the ventral anterior limb of the internal capsule for m

内囊腹侧前肢深部脑刺激治疗

• 批准号: 7847938
• 负责人: Andre Guelman Machado
• 金额: $ 235.5万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7847938
• 关键词: Absence of pain sensation; Affect; Affective; Analgesics; Anesthesia procedures; Anterior; Area; Behavior Control; Biological Neural Networks; Chronic; Country; Deep Brain Stimulation; Disabled Persons; Double-Blind Method; Emotions; Enrollment; Evaluation; Family Practice; Fiber; Functional Magnetic Resonance Imaging; Goals; Individual; Infusion procedures; Injury; Internal Capsule; Intractable Pain; Limb structure; Magnetoencephalography; Narcotics; Neural Pathways; Neurostimulation procedures of spinal cord tissue; Outcome Measure; Pain; Pain management; Pathway interactions; Patients; Population; Refractory; Research; Sensory; Syndrome; Thalamic structure; United States; Visual; abstracting; analog; base; chronic neuropathic pain; chronic pain; disability; indexing; innovation; neural circuit; neuroregulation; open label; painful neuropathy; primary outcome; public health relevance; secondary outcome; thalamic pain; transmission process

DESCRIPTION (Provided by the applicant) Abstract: Chronic neuropathic pain is a common cause of disability in the population. Most treatment options for patients with medically refractory neuropathic pain, such as spinal cord stimulation, thalamic deep brain stimulation or intrathecal infusion of narcotics, are aimed at producing analgesia and are known to have limited efficacy. We propose an innovative neuromodulation-based approach to treat patients with central thalamic pain syndrome, a particularly severe form of neuropathic pain characterized by relentless anesthesia dolorosa resulting from injury to the thalamic sensory pathways. We depart from the traditional goal of intervening in the sensory discriminative neural pathways of pain transmission in order to produce analgesia. Instead, we plan to target with deep brain stimulation (DBS) the ventral area of the anterior limb of the internal capsule (ALIC), a region densely populated by fibers related to neural networks related to the control of behavior and emotion. By electrically stimulating these networks, we expect to modulate the affective sphere of patients with otherwise intractable pain and, consequently, reduce pain related disability. We hypothesize that the improvement in pain related disability associated with modulation of the affective pain sphere will not be dependent on analgesic effects. For this reason, the visual analog scale will be used as a secondary outcome measure to control for pain levels and analgesia but the primary outcome measure of the study will be the pain disability index. Patients enrolled in this research will undergo baseline and post-DBS double blinded evaluations for a period of six months, followed by chronic open label stimulation. The neural circuits of emotion control and the effects of DBS upon these networks will be studied at regular intervals with functional magnetic resonance imaging and magnetoencephalography. Public Health Relevance: Chronic neuropathic pain is very common in the population, affecting 8% of individuals enrolled in family practices. It is a leading cause of disability in the United States and other countries. Although several treatment options exist, large shares of patients with chronic pain (up to 50%) fail to respond and remain disabled. In this proposal, we describe an innovative approach to alleviate suffering and disability among those with severe and refractory chronic neuropathic pain.

描述（由申请人提供） 翻译后摘要：慢性神经性疼痛是一种常见的原因，残疾的人口。对于医学上难治性神经性疼痛患者的大多数治疗选择，例如脊髓刺激、丘脑脑深部刺激或鞘内注射麻醉剂，旨在产生镇痛作用，并且已知疗效有限。我们提出了一种创新的基于神经调节的方法来治疗中枢丘脑疼痛综合征患者，中枢丘脑疼痛综合征是一种特别严重的神经性疼痛，其特征是丘脑感觉通路损伤导致的无情的麻醉痛。我们偏离了传统的目标，即干预疼痛传递的感觉辨别神经通路以产生镇痛。相反，我们计划用脑深部电刺激（DBS）靶向内囊前肢（ALIC）的腹侧区域，这是一个密集分布着与行为和情绪控制相关的神经网络相关的纤维的区域。通过电刺激这些网络，我们期望调节患有其他顽固性疼痛的患者的情感范围，从而减少疼痛相关的残疾。我们假设，与情感疼痛领域的调制相关的疼痛相关残疾的改善将不依赖于镇痛效果。因此，视觉模拟量表将用作控制疼痛水平和镇痛的次要结局指标，但研究的主要结局指标将是疼痛残疾指数。入组本研究的患者将接受为期6个月的基线和DBS后双盲评价，随后接受慢性开放标签刺激。情绪控制的神经回路和DBS对这些网络的影响将定期用功能性磁共振成像和脑磁图进行研究。 公共卫生相关性：慢性神经性疼痛在人群中非常常见，影响了8%参加家庭实践的个人。它是美国和其他国家残疾的主要原因。虽然有几种治疗方案，但大部分慢性疼痛患者（高达50%）没有反应并保持残疾。在这项提案中，我们描述了一种创新的方法，以减轻痛苦和残疾的严重和难治性慢性神经性疼痛。