Extramural Research Facilities Improvement Program

描述(由申请人提供)： 拟议项目的长期目标是在菲茨帕特里克跨学科工程、医学和应用科学中心(CIEMAS)内创建一个独特的、最先进的生物工程和生物医学研究设施。该设施将把生物医学工程师与生物医学科学家和临床医生联合起来，开发新的设备、生物和疾病疗法。具体地说，我们要求提供资金，以完成CIEMAS地下室的炮击空间，用于隔间和研究实验室和办公室。该提案的具体目标是：1)使生物医学工程师与细胞生物学家、临床医生和基因组研究人员密切接触，以便他们能够联合起来，加快基础研究进展的转化；2)应用先进的成像技术来识别小动物的表型变异；3)提供具有易于适应当前和未来研究需要的模块单元的设施；4)提供可供设施中的所有研究人员和合作者随时使用的公共研究资源；5)创建公共基础设施资源，以最大限度和有效地利用空间；6)提供扩大的动物收容所--2,520个鼠笼、480个鼠笼和40个其他类型的动物收容所(如豚鼠)--这将显著增强长期动物收容所，并为CIEMAS的研究人员提供卫星设施；以及7)将动物研究和公共空间明确分开，以便可以严格控制和监控安全、噪音和空气处理，这对高质量的动物护理和生物医学研究至关重要。

DESCRIPTION (provided by applicant): The long-term objective of the proposed project is to create a unique, state-of-the-art facility for bioengineering and biomedical research within the Fitzpatrick Center for Interdisciplinary Engineering, Medicine and Applied Sciences (CIEMAS). This facility will unite biomedical engineers with biomedical scientists and clinicians to develop new devices, biologies and disease therapies. Specifically, we request funds to complete shelled space in the basement of CIEMAS for a vivarium and research laboratories and offices. Specific Aims of the proposal are to: 1) bring biomedical engineers in close proximity to cell biologists, clinicians and genomic researchers so that they can join forces to accelerate the translation of basic research advances; 2) apply advanced imaging technologies to identify phenotypic variations in small animals; 3) provide a facility with modular units that are easily adaptable to current and future research needs; 4) offer common research resources that can be readily used by all researchers in the facility and by collaborators; 5) create common infrastructure resources so that space is used maximally and efficiently; 6) provide expanded animal housing - 2,520 mouse cages, 480 rat cages, and 40 other types (e.g., guinea pig) - that will markedly enhance long-term animal housing and provide a satellite facility for researchers in CIEMAS; and 7) establish a clear separation of animal research and public space so that security, noise, and air-handling can be tightly controlled and monitored, which is essential for high quality animal care and biomedical research.