Extramural Research Facilities Improvement Program

描述（由申请人提供）： 该项目的长期目标是在菲茨帕特里克跨学科工程、医学和应用科学中心 (CIEMAS) 内创建一个独特、最先进的生物工程和生物医学研究设施。该设施将联合生物医学工程师、生物医学科学家和临床医生来开发新设备、生物制剂和疾病疗法。具体来说，我们请求资金来完成 CIEMAS 地下室的外壳空间，用于动物园、研究实验室和办公室。该提案的具体目标是：1）让生物医学工程师与细胞生物学家、临床医生和基因组研究人员近距离接触，以便他们能够联手加速基础研究进展的转化； 2）应用先进的成像技术来识别小动物的表型变异； 3）提供具有模块化单元的设施，可以轻松适应当前和未来的研究需求； 4) 提供公共研究资源，可供设施中的所有研究人员和合作者轻松使用； 5) 创建公共基础设施资源，以便最大限度、高效地利用空间； 6) 提供扩大的动物圈舍 - 2,520 个小鼠笼、480 个大鼠笼和 40 个其他类型（例如豚鼠） - 这将显着改善长期动物圈舍并为 CIEMAS 的研究人员提供卫星设施； 7) 将动物研究和公共空间明确分开，以便严格控制和监测安全、噪音和空气处理，这对于高质量的动物护理和生物医学研究至关重要。

DESCRIPTION (provided by applicant): The long-term objective of the proposed project is to create a unique, state-of-the-art facility for bioengineering and biomedical research within the Fitzpatrick Center for Interdisciplinary Engineering, Medicine and Applied Sciences (CIEMAS). This facility will unite biomedical engineers with biomedical scientists and clinicians to develop new devices, biologies and disease therapies. Specifically, we request funds to complete shelled space in the basement of CIEMAS for a vivarium and research laboratories and offices. Specific Aims of the proposal are to: 1) bring biomedical engineers in close proximity to cell biologists, clinicians and genomic researchers so that they can join forces to accelerate the translation of basic research advances; 2) apply advanced imaging technologies to identify phenotypic variations in small animals; 3) provide a facility with modular units that are easily adaptable to current and future research needs; 4) offer common research resources that can be readily used by all researchers in the facility and by collaborators; 5) create common infrastructure resources so that space is used maximally and efficiently; 6) provide expanded animal housing - 2,520 mouse cages, 480 rat cages, and 40 other types (e.g., guinea pig) - that will markedly enhance long-term animal housing and provide a satellite facility for researchers in CIEMAS; and 7) establish a clear separation of animal research and public space so that security, noise, and air-handling can be tightly controlled and monitored, which is essential for high quality animal care and biomedical research.