U.S./Costa Rica Neuropsychiatric Genetics Research Training Program

美国/哥斯达黎加神经精神遗传学研究培训计划

• 批准号: 7695344
• 负责人: Michael A Escamilla
• 金额: $ 5.65万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-08 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7695344
• 关键词: Aging; Area; Biological; Bipolar Disorder; Central America; Chronic; Clinical; Clinical assessments; Cognitive; Complement; Costa Rica; Costa Rican; Country; Dementia; Development; Disease; Doctor of Philosophy; Fellowship; Funding; Genetic; Genetic Research; Goals; Grant; Health; Healthcare; Impaired cognition; Knowledge; Life; Longevity; Measures; Medical; Nerve Degeneration; Neurodevelopmental Disorder; Phenotype; Postdoctoral Fellow; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Schizophrenia; Scientist; Students; Testing; Training; Training Programs; Universities; base; experience; high standard; improved; interest; neuroimaging; neuropathology; neuropsychiatry; prevent; programs; psychologic; public health relevance

DESCRIPTION (provided by applicant): Costa Rica has progressed rapidly in the last fifty years and has the highest standard of living in Central America. Despite these gains significant health problems continue to severely impact the country. Of these illnesses, neuropsychiatric/neurodevelopmental disorders such as schizophrenia, bipolar disorder and progressive dementias pose a particular burden. With increasing longevity these illness require progressively greater resources to adequately treat them. Additionally, while health care and its infrastructure has greatly improved, there has not been the same progress in the development of independent sustainable Costa Rica- based research and scientists. This application's goal is to provide funding to continue this very successful program. Although we have been successful in training medical scientists for the University of Costa Rica since the inception of our Fogarty-funded training program in 2002, we have identified needed improvements in several areas and will implement them in the current project: One goal is to provide training for Ph.D students, who will now be fully integrated in the Biomedical Graduate Program and will focus on the genetics of these chronic neurodevelopmental disorders. While their base training will be in genetics, we recognize that genetics is not monolithic but requires knowledge of the biological context. Thus we will also encourage our Ph.D trainees to take advantage of the full range of potential academic programs at our training center and affiliated programs at our university, to complement their genetic training. We will also limit the post doctoral program to training in identifying a variety of phenotypes using the three most needed technological approaches for the research program at the University of Costa Rica and additional training in clinical assessments related to disorders of aging and neurodegeneration. The phenotyping variables of interest are neuroimaging, neuropathology and cognitive testing and clinical experiences will be in measuring and assessing dementias and cognitive declines associated with aging. As new developments in phenotyping related to schizophrenia and bipolar disorder develop, we will also accommodate targeted mini- fellowships for psychiatric and psychologic researchers as well. PUBLIC HEALTH RELEVANCE: We have identified neurodevelopmental disorders as serious, understudied health problems in Costa Rica. One of the biggest impediments to sustainable advances to prevent and treat these illnesses are the lack of Costa Rican Scientist studying these illnesses, especially in the area of genetics. To overcome this problem this grant extends our current Costa Rican Training Program to include the study of the genetics of neurodevelopmental disorders.

描述（由申请人提供）：哥斯达黎加在过去五十年中发展迅速，在中美洲拥有最高的生活水平。尽管取得了这些成就，但重大的健康问题继续严重影响着该国。在这些疾病中，精神分裂症、躁郁症和进行性痴呆等神经精神/神经发育障碍造成了特别的负担。随着寿命的延长，这些疾病需要越来越多的资源来充分治疗。此外，虽然保健及其基础设施有了很大改善，但在发展独立的可持续哥斯达黎加研究和科学家方面没有取得同样的进展。这个应用程序的目标是提供资金，继续这个非常成功的计划。尽管自2002年Fogarty资助的培训计划开始以来，我们已经成功地为哥斯达黎加大学培训了医学科学家，但我们已经确定了几个领域需要改进的地方，并将在当前项目中实施这些改进：一个目标是为博士生提供培训，他现在将完全融入生物医学研究生课程，并将专注于这些慢性神经发育障碍的遗传学。虽然他们的基础训练将在遗传学，我们认识到，遗传学不是铁板一块，但需要生物背景的知识。因此，我们还将鼓励我们的博士生利用我们培训中心和我们大学附属项目的全方位潜在学术课程，以补充他们的遗传训练。我们还将限制博士后计划的培训，以确定各种表型使用三个最需要的技术方法在哥斯达黎加大学的研究计划和额外的培训，在临床评估有关的疾病的老化和神经退行性疾病。感兴趣的表型变量是神经影像学、神经病理学和认知测试，临床经验将用于测量和评估与衰老相关的痴呆和认知下降。随着与精神分裂症和双相情感障碍相关的表型研究的新进展，我们还将为精神病和心理学研究人员提供有针对性的迷你奖学金。公共卫生相关性：我们已经确定神经发育障碍是哥斯达黎加严重的、研究不足的健康问题。在预防和治疗这些疾病方面取得可持续进展的最大障碍之一是缺乏研究这些疾病的哥斯达黎加科学家，特别是在遗传学领域。为了克服这一问题，这项赠款扩大了我们目前的哥斯达黎加培训方案，将神经发育障碍遗传学研究包括在内。