U.S./Costa Rica Neuropsychiatric Genetics Research Training Program

美国/哥斯达黎加神经精神遗传学研究培训计划

• 批准号: 7910548
• 负责人: Michael A Escamilla
• 金额: $ 22.26万
• 依托单位: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-08 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7910548
• 关键词: Aging; Area; Biological; Bipolar Disorder; Central America; Chronic; Clinical; Clinical assessments; Cognitive; Complement; Costa Rica; Costa Rican; Country; Dementia; Development; Disease; Doctor of Philosophy; Fellowship; Funding; Genetic; Genetic Research; Goals; Grant; Health; Healthcare; Impaired cognition; Knowledge; Life; Longevity; Measures; Medical; Nerve Degeneration; Neurodevelopmental Disorder; Phenotype; Postdoctoral Fellow; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Schizophrenia; Scientist; Students; Testing; Training; Training Programs; Universities; base; experience; high standard; improved; interest; neuroimaging; neuropathology; neuropsychiatry; prevent; programs; psychologic; public health relevance

DESCRIPTION (provided by applicant): Costa Rica has progressed rapidly in the last fifty years and has the highest standard of living in Central America. Despite these gains significant health problems continue to severely impact the country. Of these illnesses, neuropsychiatric/neurodevelopmental disorders such as schizophrenia, bipolar disorder and progressive dementias pose a particular burden. With increasing longevity these illness require progressively greater resources to adequately treat them. Additionally, while health care and its infrastructure has greatly improved, there has not been the same progress in the development of independent sustainable Costa Rica- based research and scientists. This application's goal is to provide funding to continue this very successful program. Although we have been successful in training medical scientists for the University of Costa Rica since the inception of our Fogarty-funded training program in 2002, we have identified needed improvements in several areas and will implement them in the current project: One goal is to provide training for Ph.D students, who will now be fully integrated in the Biomedical Graduate Program and will focus on the genetics of these chronic neurodevelopmental disorders. While their base training will be in genetics, we recognize that genetics is not monolithic but requires knowledge of the biological context. Thus we will also encourage our Ph.D trainees to take advantage of the full range of potential academic programs at our training center and affiliated programs at our university, to complement their genetic training. We will also limit the post doctoral program to training in identifying a variety of phenotypes using the three most needed technological approaches for the research program at the University of Costa Rica and additional training in clinical assessments related to disorders of aging and neurodegeneration. The phenotyping variables of interest are neuroimaging, neuropathology and cognitive testing and clinical experiences will be in measuring and assessing dementias and cognitive declines associated with aging. As new developments in phenotyping related to schizophrenia and bipolar disorder develop, we will also accommodate targeted mini- fellowships for psychiatric and psychologic researchers as well. PUBLIC HEALTH RELEVANCE: We have identified neurodevelopmental disorders as serious, understudied health problems in Costa Rica. One of the biggest impediments to sustainable advances to prevent and treat these illnesses are the lack of Costa Rican Scientist studying these illnesses, especially in the area of genetics. To overcome this problem this grant extends our current Costa Rican Training Program to include the study of the genetics of neurodevelopmental disorders.

描述（由申请人提供）：哥斯达黎加在过去的五十年中取得了迅速的进步，并且在中美洲的生活水平最高。尽管有这些问题，但健康问题仍在严重影响该国。在这些疾病中，神经精神/神经发育障碍，例如精神分裂症，双相情感障碍和进行性痴呆症，会造成特殊的负担。随着寿命的增加，这些疾病需要逐渐增加资源才能充分治疗它们。此外，尽管医疗保健及其基础设施大大改善，但在基于哥斯达黎加的独立可持续性研究和科学家的发展方面并没有取得相同的进步。该应用程序的目标是提供资金，以继续这项非常成功的计划。尽管自2002年Fogarty资助的培训计划成立以来，我们就已经成功地培训了哥斯达黎加大学的医学科学家，但我们已经确定了在几个领域的需要进行的改进，并将在当前项目中实施它们：一个目标是为Ph.D学生提供培训，他们将完全集成这些生物医学研究生级的遗传学neetrode neurode neurode neurords necorrest of ChreTical Neurode nection。尽管他们的基础训练将是遗传学的，但我们认识到遗传学不是单一的，而是需要了解生物学环境的知识。因此，我们还将鼓励我们的博士学位学员利用我们的培训中心的各种潜在学术课程以及我们大学的附属计划，以补充他们的基因培训。我们还将使用哥斯达黎加大学研究计划的三种最需要的技术方法以及与与衰老和神经变性疾病有关的临床评估进行其他培训，以限制博士后课程来识别各种表型的培训。感兴趣的表型变量是神经影像学，神经病理学和认知测试，临床经验将在测量和评估痴呆症和与衰老相关的认知下降。随着与精神分裂症和躁郁症有关的表型的新发展，我们还将为精神病和心理学研究人员提供针对性的迷你奖学金。公共卫生相关性：我们已经确定神经发育障碍是哥斯达黎加严重，研究的健康问题。预防和治疗这些疾病的可持续进步的最大障碍之一是缺乏研究这些疾病的哥斯达黎加科学家，尤其是在遗传学领域。为了克服这个问题，该赠款扩展了我们当前的哥斯达黎加培训计划，以包括对神经发育障碍的遗传学的研究。