Oral Cancer Screening via Spectral Cytopathology

通过光谱细胞病理学筛查口腔癌

• 批准号: 7990194
• 负责人: MAX DIEM
• 金额: $ 20.29万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7990194
• 关键词: Abnormal Cell; Address; Alcohol consumption; Algorithms; Benign; Biochemical; Biopsy; Boston; Cancer Detection; Cancer Patient; Cancerous; Cells; Cervical Cancer Screening; Cessation of life; Clinical; Clinical Trials; Collaborations; Computers; Coupled; Cytology Histology; Cytopathology; DNA; Data; Data Set; Databases; Dental; Detection; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Disease; Early treatment; Epithelial; Ethnic Origin; Funding Mechanisms; Gender; Hand; Head and Neck Cancer; Head and Neck Part; Head and neck structure; Health; Healthcare; Herpes Simplex Infections; Hodgkin Disease; Individual; Invaded; Laboratories; Lesion; Location; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of nasopharynx; Malignant neoplasm of testis; Measurement; Medical center; Methodology; Methods; Monitor; Morbidity - disease rate; Mouth Diseases; Nasal cavity; Neck; Neoplasm Metastasis; Nicotine; Oral; Oral cavity; Pathology; Patients; Population; Premalignant; Preparation; Primary Neoplasm; Process; Race; Recurrence; Research; Research Ethics Committees; Sampling; School Dentistry; Screening for Oral Cancer; Screening for cancer; Screening procedure; Sensitivity and Specificity; Staging; Structure; Students; Survival Rate; Symptoms; System; Techniques; Testing; Time; Tissues; Training; Universities; Variant; Virus Diseases; Visit; Work; base; clinical application; clinically relevant; clinically significant; cost; data acquisition; high risk; improved; lymph nodes; malignant mouth neoplasm; melanoma; mortality; novel diagnostics; pre-clinical; public health relevance; response; tumor

DESCRIPTION (provided by applicant): This Application is submitted in response to PA-09-238 "Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis" under the R21 funding mechanism. The work proposed in this application is aimed at developing automatic screening methods for oral and nasopharyngeal cancer, based on Spectral Cytopathology (SCP) which is a new diagnostic method based on a spectroscopic measurement of individual cells coupled to computer-based analysis. Proof-of-principle for detecting abnormal cells from the oral cavity via SCP was achieved, and identification of abnormal cells was found to be possible even before morphological changes occur in the cells. This proposal emphasizes the clinical significance of oral cancer screening by spectral methods; furthermore, it will extend the study to other parts of the head-and-neck (H&N) region, and collect datasets of sufficient size to attract other funding mechanisms to take this research to a commercial product. Oral and H&N cancer screening was selected for a target because such screening is not being carried out at this point, although cancers of the oral cavity are a major health problem, with a mean 5- year survival rate less than that of cancers which are more in the public's view, such Hodgkin's lymphoma, testicular cancer, or malignant melanoma. As in all epithelial cancers, early detection and treatment will increase the survival rate from H&N cancers, which presently are detected often after they have penetrated deeply into the surrounding tissue, or have formed metastases. SCP-based oral and H&N cancer screening can be carried out as easily as cervical cancer screening, and will reduce the complications and mortality from this disease.

描述(申请人提供)：本申请是响应PA-09-238“癌症检测和诊断中的脱落细胞和循环DNA”在R21资助机制下提交的。本申请中提出的工作旨在开发基于光谱细胞病理学(SCP)的口腔和鼻咽癌自动筛查方法，SCP是一种新的诊断方法，基于对单个细胞的光谱测量和基于计算机的分析。实现了通过SCP从口腔中检测异常细胞的原理证明，并发现甚至在细胞发生形态变化之前就可以识别异常细胞。这项建议强调了用光谱方法进行口腔癌筛查的临床意义；此外，它将把这项研究扩展到头颈部(H&N)区域的其他部分，并收集足够大的数据集，以吸引其他资助机制将这项研究转化为商业产品。之所以选择口腔和H&N癌症筛查作为目标，是因为目前还没有进行这样的筛查，尽管口腔癌是一个主要的健康问题，其平均5年存活率低于公众认为更多的癌症，如霍奇金淋巴瘤、睾丸癌或恶性黑色素瘤。与所有上皮性癌症一样，早期发现和治疗将提高H&N癌的存活率，目前H&N癌通常是在深入到周围组织或形成转移后才被发现。基于SCP的口腔和H&N癌筛查可以像宫颈癌筛查一样容易进行，并将减少这种疾病的并发症和死亡率。