Oral Cancer Screening via Spectral Cytopathology

通过光谱细胞病理学筛查口腔癌

• 批准号: 8088196
• 负责人: MAX DIEM
• 金额: $ 16.4万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8088196
• 关键词: Abbreviations; Abnormal Cell; Address; Administrative Supplement; Affect; Alcohol consumption; Algorithms; Benign; Biochemical; Biological Assay; Biological Markers; Biopsy; Boston; Cancer Detection; Cancer Etiology; Cancer Patient; Cancerous; Cells; Cellular Morphology; Cervical Cancer Screening; Cessation of life; Clinical; Clinical Trials; Collaborations; Collecting Cell; Computers; Conceptions; Coupled; Cytology; Cytology Histology; Cytopathology; DNA; Data; Data Set; Databases; Dental; Dental Hygienists; Dentists; Detection; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Diagnostic tests; Discrimination; Disease; Early treatment; Epithelial; Ethnic Origin; Fixatives; Funding Mechanisms; Gender; Gene Structure; Head and Neck Cancer; Head and Neck Part; Head and neck structure; Health; Healthcare; Herpes Simplex Infections; Hodgkin Disease; Individual; Institutional Review Boards; Invaded; Knowledge; Laboratories; Lesion; Location; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of nasopharynx; Malignant neoplasm of testis; Measurement; Measures; Medical center; Methodology; Methods; Mining; Molecular; Monitor; Morbidity - disease rate; Mouth Diseases; Multivariate Analysis; Nasal cavity; Neck; Neoplasm Metastasis; Nicotine; Normal Cell; Oral; Oral cavity; Paper; Pathology; Patients; Physicians; Population; Premalignant; Preparation; Prevention; Primary Neoplasm; Principal Component Analysis; Process; Proteins; Proteome; Published Comment; Publishing; Race; Reading; Recurrence; Relative (related person); Research; Sampling; School Dentistry; Screening for Oral Cancer; Screening for cancer; Screening procedure; Sensitivity and Specificity; Shapes; Signal Transduction; Staging; Structure; Students; Survival Rate; Symptoms; System; Techniques; Testing; Text; Time; Tissues; Training; Tumor Tissue; Universities; Variant; Virus Diseases; Visit; Voice; Work; base; cancer cell; cancer diagnosis; clinical application; clinically relevant; clinically significant; cost; data acquisition; high risk; improved; lymph nodes; malignant mouth neoplasm; melanoma; mortality; novel diagnostics; pre-clinical; response; sample fixation; tissue fixing; tool; tumor

DESCRIPTION (provided by applicant): This Application is submitted in response to PA-09-238 "Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis" under the R21 funding mechanism. The work proposed in this application is aimed at developing automatic screening methods for oral and nasopharyngeal cancer, based on Spectral Cytopathology (SCP) which is a new diagnostic method based on a spectroscopic measurement of individual cells coupled to computer-based analysis. Proof-of-principle for detecting abnormal cells from the oral cavity via SCP was achieved, and identification of abnormal cells was found to be possible even before morphological changes occur in the cells. This proposal emphasizes the clinical significance of oral cancer screening by spectral methods; furthermore, it will extend the study to other parts of the head-and-neck (H&N) region, and collect datasets of sufficient size to attract other funding mechanisms to take this research to a commercial product. Oral and H&N cancer screening was selected for a target because such screening is not being carried out at this point, although cancers of the oral cavity are a major health problem, with a mean 5- year survival rate less than that of cancers which are more in the public's view, such Hodgkin's lymphoma, testicular cancer, or malignant melanoma. As in all epithelial cancers, early detection and treatment will increase the survival rate from H&N cancers, which presently are detected often after they have penetrated deeply into the surrounding tissue, or have formed metastases. SCP-based oral and H&N cancer screening can be carried out as easily as cervical cancer screening, and will reduce the complications and mortality from this disease.

描述（由申请人提供）：在R21融资机制下，该申请是针对PA-09-238“癌症检测和诊断中的脱落细胞和循环DNA”提交的。基于光谱细胞病理学（SCP），该应用程序中提出的工作旨在开发口服和鼻咽癌的自动筛查方法，该方法基于对基于计算机基于计算机的分析的单个细胞的光谱测量，这是一种新的诊断方法。通过SCP从口腔中检测出异常细胞的原理证明，甚至在细胞中形态变化发生之前就发现了异常细胞的鉴定。该提议强调了通过光谱方法进行口腔癌筛查的临床意义。此外，它将研究将研究扩展到头颈（H＆N）区域的其他部分，并收集足够大小的数据集，以吸引其他资金机制将这项研究带入商业产品。由于目前尚未进行筛查，因此选择了口腔和H＆N癌症筛查，尽管口腔癌是一个主要的健康问题，但平均5年的存活率小于公众认为霍奇金的淋巴瘤，睾丸癌，睾丸癌，或恶性糖果的癌症的平均生存率。与所有上皮癌一样，早期检测和治疗将增加H＆N癌症的存活率，H＆N癌症目前经常被检测到它们深入到周围组织中或形成转移量后。基于SCP的口服和H＆N癌症筛查可以像宫颈癌筛查一样容易，并将降低这种疾病的并发症和死亡率。

项目成果

Vibrational spectroscopic changes of B-lymphocytes upon activation.

B 淋巴细胞激活后的振动光谱变化。

• DOI: 10.1002/jbio.201200136
• 发表时间: 2013
• 期刊: Journal of biophotonics
• 影响因子: 2.8
• 作者: Mazur,AntonellaI;Monahan,JenniferL;Miljkovic,Milos;Laver,Nora;Diem,Max;Bird,Benjamin
• 通讯作者: Bird,Benjamin