Southern California Primary Infection Program

南加州初级感染计划

• 批准号: 7931675
• 负责人: DOUGLAS D RICHMAN
• 金额: $ 1.3万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-21 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7931675
• 关键词: Acute; Anti-Retroviral Agents; Apoptosis; Arts; Autologous; CD8B1 gene; California; Collaborations; Communication; Consensus; Databases; Generations; HIV; HIV Infections; HIV drug resistance; Immune response; Infection; Information Dissemination; Length; Longitudinal Studies; Los Angeles; Methods; Mutation; Natural History; Pathogenesis; Pharmaceutical Preparations; Population Biology; Preparation; Proliferating; Reading Frames; Relative (related person); Research Personnel; Resources; Role; Series; Site; System; Technology; Therapeutic Intervention; Training and Education; Vaccines; Virus; cohort; data management; design; genital secretion; neutralizing antibody; prevent; programs; prophylactic; response; therapeutic vaccine; transmission process

DESCRIPTION (provided by applicant): The Southern California Primary Infection Program includes sites in San Diego and Los Angeles with a track record of identifying substantial cohorts with acute and early HIV infection. These cohorts have participated in longitudinal studies of natural history, pathogenesis, and therapeutic interventions with both antiretroviral drugs and vaccines. A series of excellent collaborations have resulted in completed studies characterizing HIV dynamics, apoptosis, CTL and CD4 proliferate responses, neutralizing antibody, and transmission of HIV drug resistance. These studies consist of both site and AIEDRP-wide studies coordinated in San Diego. Ongoing and proposed studies include the characterization of CD4 and CD8 responses to full length HIV reading frames, the relative contributions of immune responses to consensus and autologous sequences of HIV, the generation of neutralizing antibody (nAb) responses to autologous virus, the emergence of escape mutations over the full length sequence of HIV to each of these immune responses, the role of Nef in CTL control of HIV infection and escape from it, the population biology of HIV in genital secretions, and the dynamics of latent HIV infection in primary infection. We have also coordinated an additional AIEDRP-wide study of CTL responses in preparation for a therapeutic vaccine study. These studies will not only help to better characterize the natural history and pathogenesis of primary HIV infection, they will provide invaluable information to design strategies to prevent HIV transmission, to reduce secondary HIV drug resistance and to design and evaluate strategies for both prophylactic and therapeutic vaccines. A major component of this application is also the commitment to provide a state-of-the-art data management system and methods capable of supporting the projects of multiple local investigators as well as complimenting the resources of the central AIEDRP database. We will develop a set of on-line resources and communications technologies that facilitate scholarly exchange, distance-independent collaboration, information dissemination, education and training.

描述（由申请方提供）：南加州原发感染项目包括圣地亚哥和洛杉矶的研究中心，这些研究中心具有识别大量急性和早期HIV感染队列的跟踪记录。这些队列参与了自然史、发病机制和抗逆转录病毒药物和疫苗治疗干预的纵向研究。一系列优秀的合作已经完成了表征HIV动力学、细胞凋亡、CTL和CD4增殖反应、中和抗体和HIV耐药性传播的研究。这些研究包括在圣地亚哥协调的研究中心和AIEDRP范围内的研究。正在进行的和拟议的研究包括对全长HIV阅读框架的CD4和CD8应答的表征、对HIV的共有序列和自体序列的免疫应答的相对贡献、对自体病毒的中和抗体（nAb）应答的产生、在HIV的全长序列上对这些免疫应答中的每一种的逃逸突变的出现，Nef在CTL控制HIV感染和逃逸中的作用，HIV在生殖器分泌物中的群体生物学，以及原发感染中潜伏HIV感染的动力学。我们还协调了一项额外的AIEDRP范围内的CTL应答研究，为治疗性疫苗研究做准备。这些研究不仅有助于更好地描述原发性艾滋病毒感染的自然史和发病机制，还将为设计预防艾滋病毒传播的策略、减少继发性艾滋病毒耐药性以及设计和评估预防性和治疗性疫苗的策略提供宝贵的信息。这一申请的一个主要组成部分也是承诺提供一个最先进的数据管理系统和方法，能够支持多个当地调查人员的项目，以及补充中央AIEDRP数据库的资源。 我们将开发一套在线资源和通信技术，以促进学术交流、远程独立合作、信息传播、教育和培训。