Transmission Correlates
传输相关性
基本信息
- 批准号:8375407
- 负责人:
- 金额:$ 107.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-03-15 至 2015-02-28
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdjuvantAffectAntibody FormationAntigensB-LymphocytesBase SequenceBehavioralBiologicalBiological AssayBloodCD4 Positive T LymphocytesCD8B1 geneCellsCellular ImmunityCellular TropismCharacteristicsChlamydiaClinicalCollaborationsComputational TechniqueConstitutionContainmentCytomegalovirusDataDiseaseEpidemiologyEpitopesExhibitsGenesGeneticGenetic MarkersGenital systemGonorrheaHIVHIV InfectionsHIV-1Health SciencesHuman Herpesvirus 2Human PapillomavirusIndividualInfectionIntegration Host FactorsInterventionLaboratoriesLengthLymphocyteLymphocyte CountMale CircumcisionMeasuresMediatingMononuclearMutationPatternPhenotypePlasmaPredispositionPrevention strategyPrincipal InvestigatorProbabilityPublishingRNAReporterReportingResearchResearch Project GrantsResistanceResourcesRiskRoleSatellite VirusesSexual TransmissionSexually Transmitted DiseasesSourceSpecimenStagingStudy SubjectSyphilisSystemT cell responseT-Lymphocyte EpitopesTestingTexasUniversitiesVaccine DesignVaccinesVariantViralViral Load resultVirusWalkersbasechemokinecofactordata managementdesignfitnessgenetic elementgenital secretiongenome sequencingimprovedindexinginsightmedical schoolsneutralizing antibodypopulation basedprogramsresponsetransmission processvaccine candidatevaccine evaluationvirus genetics
项目摘要
Project 2 (Transmission Correlates) will characterize the biological, viral, and host correlates of HIV
sexual transmission. The Clinical and Specimen Core will identify study subjects and provide the blood and
genital secretion specimens for the research projects. Project 1 (Transmission Probability) will ascertain
rates of transmission and generate epidemiological and behavioral data. The Administrative Core will
coordinate these activities together with data management, and provide the statistical and analytical
resources to permit robust and valid conclusions regarding the data.
Aim 1 of Project 2 will measure the biologic correlates of sexual transmission of HIV. These include viral
loads in blood and the genital tract, lymphocyte numbers in genital secretions, and the presence of viral and
bacterial sexually transmitted infections. This aim will also address whether sexually transmitted HIV
infection is mediated by cell-free virus or by virus-infected lymphocytes.
Aim 2 will assess the viral correlates of sexual transmission of HIV. Extensive nucleotide sequencing
will extend our published observations characterizing virus in the genital compartment. The objective will be
to characterize the genotypic and phenotypic characteristics of transmitted HIV-1 variants.
Aim 3 will investigate host determinants of sexual transmission of HIV. We will extend our studies of the
neutralizing antibody response to HIV infection by determining the role of neutralizing antibody in blood and
the genital tract in selecting for transmitted viral variants. The other two components of the aim will leverage
our well characterized study subjects and their clinical specimens with two internationally recognized
laboratories with longstanding collaborations with our group. Dr. Sunil Ahuja from the University of Texas
Health Sciences Center will characterize the host genetics of both index subjects and their transmitting
partners. Drs. Walker, Allen, and Altfeld from Harvard Medical School will provide full length HIV genome
sequencing, viral phenotype, and CTL analyses that will characterize the role of cell mediated immunity,
escape, and fitness.
Each of these Aims is designed to address specific hypotheses. The data collected in Project 2,
together with the epidemiologic and behavioral data from Project 1, will permit comprehensive analyses to
determine which parameters are confounding, dependent, or independent determinants of HIV sexual
transmission. These insights should provide important leads into the design of better vaccine candidates
and other preventive strategies.
项目2(传播相关因素)将描述HIV的生物学、病毒和宿主相关因素
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DOUGLAS D RICHMAN其他文献
DOUGLAS D RICHMAN的其他文献
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{{ truncateString('DOUGLAS D RICHMAN', 18)}}的其他基金
Measuring the Latent Reservoir and Monitoring Eradication Strategies
测量潜在储库并监测根除策略
- 批准号:
8326895 - 财政年份:2011
- 资助金额:
$ 107.36万 - 项目类别:
Gene expression biomarkers of immune recovery in HIV infected patients
HIV感染者免疫恢复的基因表达生物标志物
- 批准号:
8591371 - 财政年份:2009
- 资助金额:
$ 107.36万 - 项目类别:
Gene expression biomarkers of immune recovery in HIV infected patients
HIV感染者免疫恢复的基因表达生物标志物
- 批准号:
8389836 - 财政年份:2009
- 资助金额:
$ 107.36万 - 项目类别:
Targeting regulators of cellular gene transcription to impact HIV latency
靶向细胞基因转录调节因子以影响 HIV 潜伏期
- 批准号:
7860484 - 财政年份:2009
- 资助金额:
$ 107.36万 - 项目类别:
Targeting regulators of cellular gene transcription to impact HIV latency
靶向细胞基因转录调节因子以影响 HIV 潜伏期
- 批准号:
7554818 - 财政年份:2009
- 资助金额:
$ 107.36万 - 项目类别:
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