Transmission Correlates
传输相关性
基本信息
- 批准号:8375407
- 负责人:
- 金额:$ 107.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-03-15 至 2015-02-28
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdjuvantAffectAntibody FormationAntigensB-LymphocytesBase SequenceBehavioralBiologicalBiological AssayBloodCD4 Positive T LymphocytesCD8B1 geneCellsCellular ImmunityCellular TropismCharacteristicsChlamydiaClinicalCollaborationsComputational TechniqueConstitutionContainmentCytomegalovirusDataDiseaseEpidemiologyEpitopesExhibitsGenesGeneticGenetic MarkersGenital systemGonorrheaHIVHIV InfectionsHIV-1Health SciencesHuman Herpesvirus 2Human PapillomavirusIndividualInfectionIntegration Host FactorsInterventionLaboratoriesLengthLymphocyteLymphocyte CountMale CircumcisionMeasuresMediatingMononuclearMutationPatternPhenotypePlasmaPredispositionPrevention strategyPrincipal InvestigatorProbabilityPublishingRNAReporterReportingResearchResearch Project GrantsResistanceResourcesRiskRoleSatellite VirusesSexual TransmissionSexually Transmitted DiseasesSourceSpecimenStagingStudy SubjectSyphilisSystemT cell responseT-Lymphocyte EpitopesTestingTexasUniversitiesVaccine DesignVaccinesVariantViralViral Load resultVirusWalkersbasechemokinecofactordata managementdesignfitnessgenetic elementgenital secretiongenome sequencingimprovedindexinginsightmedical schoolsneutralizing antibodypopulation basedprogramsresponsetransmission processvaccine candidatevaccine evaluationvirus genetics
项目摘要
Project 2 (Transmission Correlates) will characterize the biological, viral, and host correlates of HIV
sexual transmission. The Clinical and Specimen Core will identify study subjects and provide the blood and
genital secretion specimens for the research projects. Project 1 (Transmission Probability) will ascertain
rates of transmission and generate epidemiological and behavioral data. The Administrative Core will
coordinate these activities together with data management, and provide the statistical and analytical
resources to permit robust and valid conclusions regarding the data.
Aim 1 of Project 2 will measure the biologic correlates of sexual transmission of HIV. These include viral
loads in blood and the genital tract, lymphocyte numbers in genital secretions, and the presence of viral and
bacterial sexually transmitted infections. This aim will also address whether sexually transmitted HIV
infection is mediated by cell-free virus or by virus-infected lymphocytes.
Aim 2 will assess the viral correlates of sexual transmission of HIV. Extensive nucleotide sequencing
will extend our published observations characterizing virus in the genital compartment. The objective will be
to characterize the genotypic and phenotypic characteristics of transmitted HIV-1 variants.
Aim 3 will investigate host determinants of sexual transmission of HIV. We will extend our studies of the
neutralizing antibody response to HIV infection by determining the role of neutralizing antibody in blood and
the genital tract in selecting for transmitted viral variants. The other two components of the aim will leverage
our well characterized study subjects and their clinical specimens with two internationally recognized
laboratories with longstanding collaborations with our group. Dr. Sunil Ahuja from the University of Texas
Health Sciences Center will characterize the host genetics of both index subjects and their transmitting
partners. Drs. Walker, Allen, and Altfeld from Harvard Medical School will provide full length HIV genome
sequencing, viral phenotype, and CTL analyses that will characterize the role of cell mediated immunity,
escape, and fitness.
Each of these Aims is designed to address specific hypotheses. The data collected in Project 2,
together with the epidemiologic and behavioral data from Project 1, will permit comprehensive analyses to
determine which parameters are confounding, dependent, or independent determinants of HIV sexual
transmission. These insights should provide important leads into the design of better vaccine candidates
and other preventive strategies.
项目2(传播相关性)将描述艾滋病毒的生物学、病毒和宿主相关性
性传播临床和标本中心将确定研究受试者,并提供血液和
生殖器分泌物标本的研究项目。项目1(传输概率)将确定
传播率,并生成流行病学和行为数据。行政核心将
协调这些活动与数据管理,并提供统计和分析
资源,以便对数据得出可靠且有效的结论。
项目2的目标1将衡量艾滋病毒性传播的生物相关因素。其中包括病毒
血液和生殖道中的载量,生殖器分泌物中的淋巴细胞数量,以及病毒和
细菌性性传播感染这一目标还将解决性传播艾滋病毒是否
感染由无细胞病毒或由病毒感染的淋巴细胞介导。
目标2将评估艾滋病毒性传播的病毒相关性。广泛核苷酸测序
将扩展我们发表的观察结果,描述生殖器隔室中的病毒。这一目标的方式是
以表征传播的HIV-1变异体的基因型和表型特征。
目标3将调查艾滋病毒性传播的宿主决定因素。我们将继续研究
通过确定血液中中和抗体的作用,
生殖道在选择传播的病毒变异。该目标的其他两个组成部分将利用
我们充分表征的研究对象及其临床标本具有两种国际公认的
与我们集团长期合作的实验室。德克萨斯大学的Sunil Ahuja博士
健康科学中心将描述两个指标受试者的宿主遗传学及其传播
伙伴来自哈佛医学院的步行者、艾伦和阿尔特菲尔德博士将提供全长艾滋病毒基因组
测序、病毒表型和CTL分析将表征细胞介导的免疫的作用,
逃生和健身
这些目标中的每一个都旨在解决特定的假设。项目2中收集的数据,
与项目1的流行病学和行为数据一起,将允许进行全面的分析,
确定哪些参数是HIV性传播的混杂、依赖或独立决定因素
传输这些见解应该为设计更好的候选疫苗提供重要的线索
以及其他预防策略。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DOUGLAS D RICHMAN其他文献
DOUGLAS D RICHMAN的其他文献
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{{ truncateString('DOUGLAS D RICHMAN', 18)}}的其他基金
Measuring the Latent Reservoir and Monitoring Eradication Strategies
测量潜在储库并监测根除策略
- 批准号:
8326895 - 财政年份:2011
- 资助金额:
$ 107.36万 - 项目类别:
Gene expression biomarkers of immune recovery in HIV infected patients
HIV感染者免疫恢复的基因表达生物标志物
- 批准号:
8591371 - 财政年份:2009
- 资助金额:
$ 107.36万 - 项目类别:
Gene expression biomarkers of immune recovery in HIV infected patients
HIV感染者免疫恢复的基因表达生物标志物
- 批准号:
8389836 - 财政年份:2009
- 资助金额:
$ 107.36万 - 项目类别:
Targeting regulators of cellular gene transcription to impact HIV latency
靶向细胞基因转录调节因子以影响 HIV 潜伏期
- 批准号:
7860484 - 财政年份:2009
- 资助金额:
$ 107.36万 - 项目类别:
Targeting regulators of cellular gene transcription to impact HIV latency
靶向细胞基因转录调节因子以影响 HIV 潜伏期
- 批准号:
7554818 - 财政年份:2009
- 资助金额:
$ 107.36万 - 项目类别:
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