Evaluation of Single Nucleotide Polymorphisms (SNPs) in diabetic macular edema

单核苷酸多态性 (SNP) 在糖尿病性黄斑水肿中的评价

• 批准号: 8175488
• 负责人: DARBY THOMPSON
• 金额: $ 1.22万
• 依托单位: THE EMMES COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2011-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8175488
• 关键词: Acquired Immunodeficiency Syndrome; Area Analyses; Back; Blindness; Blood Glucose; Blood Vessels; Blood specimen; Case-Control Studies; Clinical Protocols; Clinical Research; Clinical Trials; Collection; Contractor; Data; Databases; Development; Diabetes Mellitus; Diabetic Retinopathy; Dyes; Early treatment; Economics; Enrollment; Epidemiology; Evaluation; Extramural Activities; Eye; Eye diseases; Flow-It; Fluorescein; Fluorescein Angiography; Fluoresceins; Genes; Genetic; Healthcare; Individual; Inherited; Injection of therapeutic agent; Intramural Research; Liquid substance; Medical History; Medicare; Monitor; Natural History; Ophthalmic examination and evaluation; Outcomes Research; Participant; Patients; Protocols documentation; Quality-of-Life Assessment; Research; Research Design; Risk; Severities; Single Nucleotide Polymorphism; Specific qualifier value; Support Contracts; Swelling; Uveitis; Vision Disorders; Work; cost effectiveness; data management; design; diabetic; diabetic patient; follow-up; macular edema; patient safety; preclinical study; trait

Evaluation of Single Nucleotide Polymorphisms (SNPs) in Patients with and without Diabetic Macular Edema Clinical Protocol support contract designed to attain extramural support for developing, designing, interpreting, and evaluating clinical trials, epidemiologic and natural history studies. In addition, it will provide for outcomes research involving eye diseases and visual disorders and some preclinical studies. The focus shall be on the design of studies and the collection, analysis, and interpretation of data emanating from these studies, as well as support, and monitoring patient safety and follow-up. Contractor shall also provide analytical and data management support, as described in the work statement, for specified clinical research data bases, cost-effectiveness and economic analyses, quality of life assessment and outcomes research. This will include, but not be limited to, the following areas: analysis of Medicare and other health care databases; evaluation of existing NEI databases such as, centralized NEI Intramural Research database, the Eye Disease Case Control Study, Early Treatment Diabetic Retinopathy Study, Framingham Eye Study, and intramural AIDS and uveitis databases. Objective of Clinical Protocol: - Diabetic macular edema (DME) is a common condition in people with diabetes. DME occurs when blood vessels in the eye leak fluid, resulting in swelling inside the back of the eye and progressive vision loss. Research has shown that good blood sugar control can reduce the risk and severity of DME. However, not all diabetic patients with poor blood sugar control develop DME, and some patients develop DME despite excellent blood sugar control. This suggests that other factors, such as genes or inherited traits, may predispose or protect a diabetic patient from developing DME. Objectives: - To investigate genetic factors that may influence the development of diabetic macular edema.

糖尿病性黄斑水肿与非糖尿病性黄斑水肿患者单核苷酸多态性（snp）的评价