ANNOTATION OF PROTEIN FUNCTION BY LIGAND DESCRIPTORS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 生物学中的一个关键问题是为已知蛋白质分配功能 序列，有时甚至是已知的结构，但未知的活性。 例子包括去孤儿受体的努力，确定靶点 基于细胞的(功能)筛选和结构基因组学。很大的努力 一直专注于生物信息学工具，但可能扮演的角色 化学信息在很大程度上被忽视了。许多蛋白质都能识别 有机分子(配体)的特征集合，或者在它们的 正常功能或作为干扰这一功能的试剂。我们 建议使用蛋白质的配体来“提取”蛋白质的指纹。基于 这个指纹与其他蛋白质的指纹相似，它应该 有可能创建基于配基化学的连接图谱并推断 蛋白质的功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A key problem in biology is assigning function to proteins of known sequence, sometimes even known structures, but unknown activity. Examples include efforts to de-orphan receptors, determine targets in cell-based (functional) screens, and structural genomics. Much effort has been focused on bioinformatics tools, but a possible role for chemical information has largely been ignored. Many proteins recognize characteristic sets of organic molecules (ligands), either in their normal function or as reagents that interrupt this function. We propose to "fingerprint" proteins using their ligands. Based on the similarity of this fingerprint to those of other proteins, it should be possible to create ligand chemistry-based linkage maps and to infer protein function.