ANNOTATION OF PROTEIN FUNCTION BY LIGAND DESCRIPTORS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 生物学中的一个关键问题是为已知的蛋白质分配功能。 序列，有时甚至是已知的结构，但未知的活动。 例子包括努力去孤儿受体，确定目标， 基于细胞的（功能）筛选和结构基因组学。多的努力 一直专注于生物信息学工具，但 化学信息在很大程度上被忽视了。许多蛋白质识别 有机分子（配体）的特征集，无论是在其 正常功能或作为中断该功能的试剂。我们 建议使用蛋白质的配体来“识别”蛋白质。基于 这种指纹与其他蛋白质的指纹相似， 可以创建基于配体化学的连锁图谱，并推断 蛋白质功能

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A key problem in biology is assigning function to proteins of known sequence, sometimes even known structures, but unknown activity. Examples include efforts to de-orphan receptors, determine targets in cell-based (functional) screens, and structural genomics. Much effort has been focused on bioinformatics tools, but a possible role for chemical information has largely been ignored. Many proteins recognize characteristic sets of organic molecules (ligands), either in their normal function or as reagents that interrupt this function. We propose to "fingerprint" proteins using their ligands. Based on the similarity of this fingerprint to those of other proteins, it should be possible to create ligand chemistry-based linkage maps and to infer protein function.