MESA

台面

• 批准号: 8065593
• 负责人: AARON R FOLSOM
• 金额: $ 4万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2015-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8065593
• 关键词: Abdomen; Ancillary Study; Ankle; Area; Atherosclerosis; Behavioral; Biological; Cardiac; Cardiovascular Diseases; Characteristics; Clinical; Contracts; Coronary Arteriosclerosis; Data; Data Set; Diabetic Angiopathies; Diabetic Retinopathy; Disease; Ethnic Origin; Event; Eye; Family; Funding; Fundus photography; Genetic; Health Status; Laboratories; Macular degeneration; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mentors; Minnesota; Myocardial; Nutritional; Participant; Pathology; Pharmaceutical Preparations; Phenotype; Photography; Policies; Population Heterogeneity; Process; Recruitment Activity; Research; Research Design; Research Personnel; Retinal; Risk Marker; Sampling; Severities; Signs and Symptoms; Systemic disease; Time; Training; Ultrasonography; United States National Institutes of Health; Universities; Ventricular Function; Visit; Visual; Visual Acuity; Visual impairment; Woman; Work; X-Ray Computed Tomography; aged; base; brachial artery; cohort; data sharing; design; digital; follow-up; imaging modality; indexing; interest; member; men; population based; psychologic; racial/ethnic difference; radial artery; sex; socioeconomics

The University of Minnesota serves as one of six Field Centers for the Multi-Ethnic Study of Atherosclerosis (MESA), a study of the correlates, predictors and progression of subclinical cardiovascular disease (CVD) (disease detected non-invasively before it has produced clinical signs and symptoms) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. Six thousand eight hundred and fourteen (6,814) participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tomometry, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, nutritional and environmental characteristics; and genetic factors. Selected components were repeated over three subsequent examinations through 2007. The cohort has been followed for clinical events since baseline to ascertain and characterize new clinical events and other changes in health status, including changes in medications. The four scientific objectives for the period 2008 through 2015 are (1) identify factors related to progression of subclinical to clinical CVD; (2) identify predictors of decline in ventricular function; (3) further understanding of the basis for racial/ethnic difference in CVD; and (4) provide a platform for in-depth ancillary studies of CVD and other areas. All surviving and willing members of the MESA cohort will be followed up during the time period and included in an fifth examination during 2010-2012. The study will support in-depth ancillary studies that are funded outside of the current contracts. These studies will be operationally integrated into the main study, and the data will be shared across both types of studies, per current MESA and NIH data-sharing policies. The study's data will be provided to interested investigators through a defined process that encourages maximum data utilization but that protects participant confidentially. The study will also serve as a training ground for junior investigators, who will work with senior investigators and be provided with access to the MESA data set and guidance on conducting research. The MESA-EYE component (refraction and fundus photography) was integrated into the second MESA visit in which 6235 people participated between September 2002 and December 2003. The aims of the ocular component were to document the presence and severity of retinal microvascular changes (as interpreted from digital retinal photos) indicative of macular degeneration and diabetic retinopathy, as well as to describe their interrelationships with cross-sectional and longitudinal measures of microvascular and macrovascular systemic disease as defined clinically, by imaging modality, or by analysis of biological laboratory measures. The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, determine the degree to which visual impairment could be reduced with better refractive correction, and correlate visual findings with retinal pathology. Analyses of various ocular phenotypes, including retinal microvascular disease in MESA Family's ancillary study.

明尼苏达大学是动脉粥样硬化多种族研究(MESA)的六个现场中心之一，该研究是一项关于亚临床心血管疾病(CVD)(在产生临床体征和症状之前非侵入性检测到的疾病)的相关性、预测因素和进展的研究，样本基于不同人群，年龄在45-84岁之间，基线没有临床心血管疾病的证据。在2000年至2002年期间，从6个野战中心招募了6,814(6,814)名参与者，检查了亚临床冠状动脉粥样硬化的证据，使用了计算机断层扫描、心脏核磁共振、颈动脉超声、血流介导的臂动脉扩张、放射动脉断层测量、踝臂指数测量和视网膜摄影，并在亚组中进行了腹主动脉CT、颈动脉核磁共振、心脏核磁共振标记以测量局部心肌功能；已建立的和可能的实验室风险标记物；社会经济、心理、行为、营养和环境特征；以及遗传因素。选定的部件在随后的三次检查中重复进行，直至2007年。自基线以来，一直跟踪临床事件队列，以确定和描述新的临床事件和健康状况的其他变化，包括药物变化。2008年至2015年期间的四个科学目标是：(1)确定与亚临床向临床心血管疾病进展有关的因素；(2)确定心功能下降的预测因素；(3)进一步了解心血管疾病种族/民族差异的基础；以及(4)为心血管疾病和其他领域的深入辅助研究提供平台。在此期间，将对MESA队列中所有幸存和自愿的成员进行跟踪，并将其纳入2010-2012年期间的第五次审查。这项研究将支持在现有合同之外提供资金的深入辅助研究。这些研究将在业务上纳入主要研究，数据将根据目前的MESA和NIH数据共享政策在两种类型的研究中共享。这项研究的数据将通过一个明确的程序提供给感兴趣的调查人员，该程序鼓励最大限度地利用数据，但保护参与者的机密。这项研究还将作为初级调查人员的培训基地，他们将与高级调查人员合作，并获得利用MESA数据集和开展研究的指导。 台眼部分(折射和眼底摄影)被纳入2002年9月至2003年12月期间有6235人参加的第二次台面访问。眼睛部分的目的是记录表明黄斑变性和糖尿病视网膜病变的视网膜微血管变化的存在和严重程度(从数字视网膜照片中解读)，并描述它们与临床、成像方式或生物实验室测量分析所定义的微血管和大血管系统疾病的横断面和纵向测量的相互关系。视力/客观屈光成分的设计是为了让我们能够根据性别和种族来估计视力损害，确定通过更好的屈光矫正可以减少视觉损害的程度，并将视觉发现与视网膜病理相关联。梅萨家族辅助研究中包括视网膜微血管疾病在内的各种眼部表型的分析。