SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER

MESA是一项为期10年的观察性研究，对亚临床心血管疾病(在产生临床体征和症状之前非侵入性检测到的疾病)和风险因素的特征进行观察，这些风险因素预测发展为临床明显的心血管疾病，并预测亚临床疾病本身的进展，研究对象为年龄在45-84岁的6500名具有代表性的男性和女性。大约40%的人将是白人，30%的非裔美国人，20%的西班牙裔和10%的华裔美国人。该队列将从六个现场中心招募，并针对各种亚临床心血管疾病措施、标准冠状动脉风险因素、社会人口因素、生活方式因素和心理社会因素进行特征分析。血液样本将被检测出可能的生化危险因素，并储存起来用于病例对照研究。DNA将被提取，淋巴细胞将永生，用于研究候选基因，并可能进行全基因组扫描。计划进行四次临床检查，间隔18-24个月。将对参与者进行跟踪，以确定和描述心血管疾病事件和接受的干预措施。

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.