CLINICAL EXAMINATION CENTER

临床检验中心

基本信息

批准号：
8429350
负责人：
AARON R FOLSOM
金额：
$ 285.43万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-11-15 至 2016-11-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8429350
关键词：
African American Age American American Heart Association Ancillary Study Atrial Fibrillation Behavioral Biological Markers Blood Vessels Cardiology Cardiovascular Diseases Cardiovascular system Caring Cessation of life Clinic Clinical Cohort Studies Communities Contracts Coronary heart disease County Dietary intake Environmental Risk Factor Epidemiologic Studies Etiology Event Genetic Genetic Markers Health Status Heart failure Incidence Individual Inpatients Measurement Medical Monitor Myocardial Infarction Natural History Outcome Outcomes Research Outpatients Participant Probability Samples Recruitment Activity Research Personnel Risk Factors Staging Stroke Telephone Training Ventricular Dysfunction Visit Washington Woman aged cohort college data sharing demographics design follow-up human old age (65+)member men mortality prospective pulmonary function social trend

项目摘要

ARIC is a prospective epidemiologic study conducted in four U.S. communities: Washington County, MD; Forsyth County, NC; Jackson, MS; and Minneapolis, MN. The study is designed to monitor the trends in incidence and mortality of coronary heart disease (CHD) and heart failure in communities, and to investigate the etiology, natural history, and progression of subclinical and clinical cardiovascular disease such as CHD, heart failure, and stroke. Accordingly, ARIC includes a Community Surveillance Component and Cohort Study Component. For the community surveillance, the four communities are investigated to determine the occurrence of hospitalized myocardial infarction and CHD deaths in approximately 800,000 men and women aged 35-84 years. Starting in 2006, surveillance of inpatient (ages 55 years and older) and outpatient heart failure (ages 65 years and older) is included for the events beginning in 2005. Under the new contract, community surveillance will continue to monitor long-term trends in hospitalized MI, CHD deaths, and heart failure (inpatient and outpatient). For the cohort study, approximately 4,000 individuals aged 45-64 years were recruited by probability sampling from each of the four communities under surveillance. A total of 15,792 participants (11,478 whites, 4,266 African Americans, and 48 other) received an extensive baseline examination in 1987-1989. Three repeat examinations were conducted in 1990-92, 1993-95, and 1996-98. The examinations collected information on demographics, psycho-social and behavioral factors, dietary intakes, physical measurements, and biological and genetic markers. Under the new contract, the surviving cohort members will receive another clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants of its decline. Participants are also contacted twice a year by telephone to assess health status. Under the new contract, the study will also be enhanced with cardiovascular outcomes research to assess quality and outcomes of medical care for heart failure risk factors and heart failure.

ARIC是一项在美国四个社区进行的前瞻性流行病学研究：马里兰州华盛顿县；北卡罗来纳州福赛斯县；杰克逊，女士；和明尼苏达州明尼阿波利斯。该研究旨在监测社区冠心病（CHD）和心力衰竭的发病率和死亡率的趋势，并研究亚临床和临床心血管疾病的病因，自然病史和进展，例如CHD，心力衰竭，心力衰竭和中风。因此，ARIC包括一个社区监视组件和队列研究部分。对于社区的监视，对这四个社区进行了调查，以确定大约80万名35-84岁的男性和女性的住院心肌梗死和冠心病死亡的发生。从2006年开始，从2005年开始对住院（55岁及55岁以上）和门诊心力衰竭（年龄在65岁以上）的监视开始。从2005年开始。根据新合同，社区监视将继续监测住院的MI，CHD，CHD，心力衰竭和心力衰竭的长期趋势。在队列研究中，大约4,000名45-64岁的人通过监视的四个社区中的每个社区中的每个社区的概率取样招募。 1987 - 1989年，共有15,792名参与者（11,478名白人，4,266名非裔美国人和48位）进行了广泛的基线检查。在1990 - 92年，1993 - 95年和1996 - 98年进行了三次重复检查。检查收集了有关人口统计学，心理社会和行为因素，饮食摄入量，身体测量以及生物学和遗传标记的信息。根据新合同，幸存的队列成员将接受另一项诊所检查，以表征心力衰竭阶段，确定导致心室功能障碍和血管僵硬的遗传和环境因素，并评估肺功能的纵向变化并确定其下降的决定因素。还每年通过电话与参与者联系，以评估健康状况。根据新合同，通过心血管结果研究，该研究还将得到增强，以评估医疗护理的质量和心力衰竭危险因素和心力衰竭。