ARIC Neurocognitive Study (ARIC-NCS)

ARIC 神经认知研究 (ARIC-NCS)

• 批准号: 9134850
• 负责人: AARON R FOLSOM
• 金额: $ 89.26万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-07 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9134850
• 关键词: Address; African American; Age; Aging; Amyloid; Ancillary Study; Arrhythmia; Arterioloscleroses; Atherosclerosis; Attention; Behavior; Biochemical; Biological Assay; Blood Vessels; Brain; Brain imaging; Cardiac; Cardiovascular Diseases; Cardiovascular system; Carotid Atherosclerotic Disease; Cerebrum; Climacteric; Clinical; Cognition; Cognitive; Collection; Communities; Contracts; County; Data; Data Collection; Dementia; Demographic Factors; Diabetes Mellitus; Diagnosis; Diagnostic; Diet; Doctor of Philosophy; Drops; Echocardiography; Elderly; Evaluation; Funding; Genetic; Genomics; Glycosylated hemoglobin A; Goals; Health; Hemostatic Agents; Hypertension; Image; Impaired cognition; Incidence; Individual; Intracranial Arterial Stenosis; Kidney; Knowledge; Laboratories; Language; Learning; Longevity; Magnetic Resonance Imaging; Manuscripts; Measures; Memory; Methods; Microvascular Dysfunction; Modification; National Heart, Lung, and Blood Institute; Nerve Degeneration; Neurocognitive; Optical Coherence Tomography; Orthostatic Hypotension; Outcome; Paper; Participant; Performance; Peripheral; Persons; Pharmaceutical Preparations; Phase; Physical Function; Physical activity; Physiologic pulse; Population; Positioning Attribute; Positron-Emission Tomography; Principal Investigator; Procedures; Process; Psychosocial Factor; Public Health; Race; Recruitment Activity; Research Infrastructure; Research Personnel; Resources; Retinal; Risk; Risk Factors; Risk Marker; Sampling; Schedule; Science; Smoking; Source; Stroke; Structure; Testing; Time; Translating; Uncertainty; Vascular Diseases; Vision; Visit; Washington; Woman; Work; adjudicate; aged; arterial stiffness; base; cognitive ability; cognitive change; cognitive performance; cognitive testing; cohort; data sharing; design; executive function; experience; follow-up; hazard; hearing impairment; inflammatory marker; meetings; men; metabolomics; middle age; mild cognitive impairment; modifiable risk; mortality; neuropsychological; processing speed; prospective; public health relevance; racial minority; response; trait; vascular contributions; vascular factor; white matter

 DESCRIPTION (provided by applicant): ARIC Neurocognitive Study (ARIC-NCS) Renewal 1 of 5 Johns Hopkins Washington County Field Center Principal Investigator (Josef Coresh, MD, PhD). Rationale: Dementia and mild cognitive impairment (MCI) pose a large and increasing health and societal burden on the aging US population and ARIC is uniquely suited to contribute critical information on the vascular, and potentially preventable, contributions to dementia and MCI incidence. Progress: ARIC NCS (Visit 5: 2011-13) measured a battery of cognitive tests on ARIC participants aged 70- 89 and all study goals were met or exceeded, completing 6,538 exams, 2009 MRIs (520 in African-Americans) with a large number of dementia and Mild Cognitive Impairment (MCI) cases currently being adjudicated. Early papers were submitted within a month of completion of data collection and promising work is ongoing (~50 manuscript proposals). Collection of cognitive decline in late-life is needed and time sensitive since the cohort is experiencing ~5% annual mortality (mean age 78 years). Design: Follow-up cognitive testing (~30-year f/u, 2015-2018), at ages where cognitive decline begins to manifest across several domains or accelerates, thus providing many additional, diverse outcomes in the ARIC cohort (15,792 men and women ages 45-65 recruited in 1986-1989 and followed with detailed examinations). Outcomes: The late life cognitive outcomes targeted in the renewal differ from the one-time static measures of cognitive performance now available from the ARIC NCS baseline exam. A. Decline in global cognitive ability, executive function/processing speed, memory, and language - assessed during in ~4214, ~4 years after V5 (more comprehensive than possible in previous visits which had a more limited 3 test battery similar to older cardiovascular studies; 2nd visit in oldest subset). B. Incidence of MCI and dementia - detect ~1,521 dementia 1,134 MCI incident cases using procedures established after NCS V5 (2011-2013; expanded ARIC's semi-annual calls; response rate ~90%). C. Progression from MCI to dementia - following the 1,402 MCI cases identified at V5. Aims: We will study a wealth of modifiable vascular risk factors and measures of microvascular disease and atherosclerosis in midlife, many not available in other studies of cognition, for their contribution to late life cogntive decline and physical function. We will study the detailed 3T brain MRI imaging at visit 5 as a risk factor for cognitive decline at older age. We will determine if any of these associations are different in African- Americans, where longitudinal cognitive data are nearly non-existent and vascular burden is high, than in white ARIC participants. We will share these data all ARIC ancillaries (Appendix 4), including detailed genetic and biochemical studies across the lifespan. Summary: This NCS visit (V6: 2015-2018; V7: 2017-2018 in oldest subset) will advance knowledge about the potentially modifiable vascular contribution to cognitive decline in late life and provide the cornerstone for other synergistic ancillary studies by a large community of investigators which would not otherwise be possible.

 描述（由申请人提供）：ARIC神经认知研究（ARIC-NCS）更新1/5约翰霍普金斯华盛顿县现场中心首席研究员（Josef Coresh，MD，PhD）。基本原理：痴呆症和轻度认知障碍（MCI）对美国老龄化人口构成了巨大且日益增加的健康和社会负担，ARIC特别适合提供有关血管的关键信息，并且可能是可预防的，有助于痴呆症和MCI的发病率。进度：ARIC NCS（访视5：2011-13）测量了一组对70- 89岁ARIC参与者的认知测试，所有研究目标都达到或超过了，完成了6，538次检查，2009次MRI（非洲裔美国人中有520次），目前正在裁定大量痴呆和轻度认知障碍（MCI）病例。早期论文在数据收集完成后一个月内提交，有希望的工作正在进行中（约50份手稿提案）。由于该队列的年死亡率约为5%（平均年龄78岁），因此需要收集晚年认知功能下降的数据，并且具有时间敏感性。设计图：随访认知测试（约30年随访，2015-2018年），在认知下降开始在多个领域出现或加速的年龄，从而在ARIC队列中提供许多额外的，不同的结果（1986-1989年招募的15，792名45-65岁的男性和女性，随后进行详细检查）。成果：更新中针对的晚年认知结果与ARIC NCS基线检查中现有的认知表现的一次性静态测量不同。总体认知能力、执行功能/处理速度、记忆和语言下降-在V5后约4年的约4214年进行评估（比之前访视更全面，之前访视的3项测试组合更有限，类似于旧的心血管研究;第2次访视在最早的子集中进行）。 B。MCI和痴呆的发病率-使用NCS V5后建立的程序检测~ 1，521例痴呆1，134例MCI事件病例（2011-2013年;扩大ARIC的半年度电话;应答率~90%）。 C.从MCI到痴呆的进展-在V5时确定的1，402例MCI病例之后。目的：我们将研究大量可改变的血管危险因素和中年微血管疾病和动脉粥样硬化的测量，许多在其他认知研究中不可用，因为它们对晚年认知下降和身体功能的贡献。我们将在访视5时研究详细的3 T脑部MRI成像，作为风险 老年认知能力下降的因素。我们将确定这些相关性在非裔美国人中是否与白色ARIC参与者不同，因为非裔美国人几乎不存在纵向认知数据，血管负担很高。我们将分享所有ARIC患者的这些数据（附录4），包括整个生命周期的详细遗传和生化研究。总结：本次NCS访视（V6：2015-2018; V7：2017-2018（最古老的子集）将推进有关血管对晚年认知能力下降的潜在可改变贡献的知识，并为大量研究者进行的其他协同辅助研究提供基石，否则这是不可能的。