PRE CLINICAL EVALUATION OF LASER PORT WINE THERAPY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 PWS是一种先天性的进行性真皮血管畸形。脉冲染料激光可以通过在目标血管内诱导微血栓形成来选择性地凝固PWS。然而，大多数患者需要多种治疗，只有一小部分患者的PWS 100%消退。本研究的目的是发展光学多谱勒断层扫描(ODT)技术，通过提供脉冲激光治疗效果的半定量评估，将其应用于PWS患者的临床治疗。ODT提供的关于血管的深度、大小和密度的信息将被用于选择用于PWS治疗的最佳脉冲持续时间和激光照射的光剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PWS is a congenital, progressive vascular malformation of the dermis. The pulsed dye laser can coagulate selectively PWS by inducing microthrombus formation within the targeted blood vessels. However, most patients requires multiple treatment and only a small proportion of patients obtain 100% fading of their PWS. The objective of the proposed research is the development of Optical Doppler Tomography (ODT) for application in the clinical management of patients with PWS by providing a semi-quantitative evaluation of the efficiency of pulsed laser therapy. The information provided by ODT on the depth, size, and density of the vasculatures will be used to select optimal pulse duration and light dosage of laser exposure for PWS therapy.