PRE CLINICAL EVALUATION OF LASER PORT WINE THERAPY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 PWS是一种先天性、进行性真皮血管畸形。 脉冲染料激光可以通过诱导靶血管内微血栓的形成来选择性地凝固PWS。然而，大多数患者需要多次治疗，只有一小部分患者的PWS达到100%消退。 拟议的研究的目的是发展光学多普勒断层扫描（ODT）的应用在PWS患者的临床管理提供了半定量的评价脉冲激光治疗的效率。 ODT提供的关于血管深度、大小和密度的信息将用于选择PWS治疗的最佳脉冲持续时间和激光照射光剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PWS is a congenital, progressive vascular malformation of the dermis. The pulsed dye laser can coagulate selectively PWS by inducing microthrombus formation within the targeted blood vessels. However, most patients requires multiple treatment and only a small proportion of patients obtain 100% fading of their PWS. The objective of the proposed research is the development of Optical Doppler Tomography (ODT) for application in the clinical management of patients with PWS by providing a semi-quantitative evaluation of the efficiency of pulsed laser therapy. The information provided by ODT on the depth, size, and density of the vasculatures will be used to select optimal pulse duration and light dosage of laser exposure for PWS therapy.