PRE CLINICAL EVALUATION OF LASER PORT WINE THERAPY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 PWS是一种先天性、进行性真皮血管畸形。 脉冲染料激光可以通过诱导靶血管内微血栓的形成来选择性地凝固PWS。然而，大多数患者需要多次治疗，只有一小部分患者的PWS达到100%消退。 拟议的研究的目的是发展光学多普勒断层扫描（ODT）的应用在PWS患者的临床管理提供了半定量的评价脉冲激光治疗的效率。 ODT提供的关于血管深度、大小和密度的信息将用于选择PWS治疗的最佳脉冲持续时间和激光照射光剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. PWS is a congenital, progressive vascular malformation of the dermis. The pulsed dye laser can coagulate selectively PWS by inducing microthrombus formation within the targeted blood vessels. However, most patients requires multiple treatment and only a small proportion of patients obtain 100% fading of their PWS. The objective of the proposed research is the development of Optical Doppler Tomography (ODT) for application in the clinical management of patients with PWS by providing a semi-quantitative evaluation of the efficiency of pulsed laser therapy. The information provided by ODT on the depth, size, and density of the vasculatures will be used to select optimal pulse duration and light dosage of laser exposure for PWS therapy.