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Structure and Function of Ascaris Neuropeptides

蛔虫神经肽的结构和功能

基本信息

批准号：
7759587
负责人：
ANTONY O. STRETTON
金额：
$ 33.71万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-02-15 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7759587
关键词：
Affect Affinity Antibodies Area Ascaris Ascaris suum Basic Science Behavior Biochemical Caenorhabditis elegans Cells Dorsal Drug resistance Family Ganglia Generations Genetic Grant High Pressure Liquid Chromatography In Situ Hybridization Indium Individual Interneurons Lasers Locomotion MALDI-TOF Mass Spectrometry Mass Spectrum Analysis Mediating Methods Molecular Molecular Biology Morphology Motor Motor Activity Motor Neurons Movement Muscle Muscle Cells Muscle Tension Myxoid cyst Nematoda Nerve Nerve Tissue Nervous system structure Neurons Neuropeptide Gene Neuropeptides Paralysed Parasitic nematode Peptides Pharmaceutical Preparations Physiological Play Positioning Attribute Process Relaxation Reporting Research Role Sampling Signal Transduction Site Source Structure System Techniques Testing Time Tissues Transcript Work base cellular targeting designer antibody falls immunocytochemistry in vivo interdisciplinary approach molecular mass neuromuscular system neuronal cell body novel protein aminoacid sequence relating to nervous system research study

项目摘要

The locomotory system of nematodes is the target of many currently used anthelminthics, since disruption of locomotory behavior interferes with the normal processes by which many nematodes maintain their position within the host. The problem of genetic drug resistance is making many of the available drugs less effective, so it is important to develop new generations of anti-nematdde drugs. The proposed research aims to describe new intercellular signaling systems that are important in the motornervous system that controls locomotion. Our strategy is based on our previous work in which we isolated and sequenced a large family of 29 novel endogenous neuropeptides in the parasitic nematode, Ascaris suum. Preliminary experiments have shown that almost all of the peptides tested have potent activity .on the neuromuscular system of Ascaris. Some cause paralysis, others exaggerate locomotory movements. Neuropeptides, therefore, play an important role in the overall activity of the motornervous system. There is every indication that there are many more peptides than the ones we have isolated so far. There is no indication that the currently available peptides are the most potent, so we propose to isolate new peptides, concentrating on those that are present in the motornervous system, in order to detect new peptides that have potent physiological activity. This is basic research upon which new generations of anthelminthics can ultimately be developed.

线虫的运动系统是许多目前使用的驱虫剂的靶标，因为运动行为的中断干扰了许多线虫维持生命的正常过程，在宿主中的位置。基因抗药性的问题使得许多可用的药物因此，开发新一代的抗抑郁药物非常重要。拟议研究目的是描述新的细胞间信号系统是重要的运动神经系统，控制运动我们的策略是基于我们以前的工作，我们分离和测序了一个大的猪蛔虫中29种新的内源性神经肽家族。初步实验表明，几乎所有测试的肽对神经肌肉蛔虫系统有些会导致瘫痪，有些则会夸大运动。神经肽，因此，在运动神经系统的整体活动中发挥重要作用。种种迹象比我们目前分离出的肽要多得多。没有迹象表明目前可用的肽是最有效的，所以我们建议分离新的肽，集中在那些存在于运动神经系统，以检测新的肽，具有强大的生理活动这是新一代驱虫药最终可以开发

项目成果

期刊论文数量（25）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Changes in cyclic nucleotides, locomotory behavior, and body length produced by novel endogenous neuropeptides in the parasitic nematode Ascaris suum.

寄生线虫猪蛔虫中新型内源神经肽产生的环核苷酸、运动行为和体长的变化。

DOI：
10.1016/j.molbiopara.2011.08.001
发表时间：
2011
期刊：
Molecular and biochemical parasitology
影响因子：
1.5
作者：
Reinitz,CatharineA;Pleva,AnthonyE;Stretton,AntonyOW
通讯作者：
Stretton,AntonyOW

The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum.

阿维菌素及乙酰胆碱、4-氨基丁酸相关药物对猪蛔虫神经传递的影响。

DOI：
10.1016/0166-6851(84)90114-2
发表时间：
1984
期刊：
Molecular and biochemical parasitology
影响因子：
1.5
作者：
Kass,IS;Stretton,AO;Wang,CC
通讯作者：
Wang,CC

Excitatory and inhibitory activity in the dorsal musculature of the nematode Ascaris evoked by single dorsal excitatory motonerons.

由单个背侧兴奋性运动元引起的线虫蛔虫背侧肌肉组织的兴奋性和抑制活性。

DOI：
10.1523/jneurosci.05-01-00016.1985
发表时间：
1985
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Walrond,JP;Stretton,AO
通讯作者：
Stretton,AO

Actions of cholinergic drugs in the nematode Ascaris suum. Complex pharmacology of muscle and motorneurons.