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UPDATE AND EXPAND VITAL RESOURCES

更新和扩展重要资源

基本信息

批准号：
8166255
负责人：
ROBERT P DOTTIN
金额：
$ 22.95万
依托单位：
HUNTER COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-14 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8166255
关键词：
10 year old Accreditation Address Animals Area Behavior Caring Cellular Structures Censuses Certification Computer Retrieval of Information on Scientific Projects Database Core Facility Data Development Drug abuse Electron Microscope Electron Microscopy Funding Gene Structure Genes Grant IACUC Image Imagery Immunology Institution Internet Investigation Laboratory Animals Lasers Microscope Modeling Molecular Monitor Nanotechnology Nervous system structure Neurobiology Organic Chemistry Output Pain Recruitment Activity Research Research Personnel Resources Running Sampling Scanning Scientist Source Time United States National Institutes of Health Update Vertebrates Veterinarians Video Microscopy analog animal care animal facility base bioimaging college digital digital imaging experimental analysis gene function health disparity image processing instrument meetings programs protein structure function repaired research study transmission process

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Scientists at the Center for Study of Gene Structure and Function (Gene Center) at Hunter College use animals in their outstanding research programs. Their investigations are monitored by an active Institutional Animal Care and Use Committee (IACUC) committee and supported by a well run Animal Facility. The facility maintains a variety of vertebrate animal species. We have made major efforts during the past funding period to upgrade and expand the Animal Care Facility. Because of the increased research involving animals, the animal census has increased significantly. To maintain adequate care and surveillance of the animals, it is now essential to hire a full-time veterinarian. We plan to recruit and hire a veterinarian with RCMI grant funds. At the end of the next five year period, the institution will provide a permanent line for this hire. These improvements will enable research scientists at the Gene Center to be more productive, especially in research that addresses health disparities. The planned improvements, including the full-time veterinarian, will also bring the facility in line with Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) standards for certification. The Digital Bio-Imaging Core Facility, established in 1995, offers visualization of sub-cellular structures with digital image processing and video microscopy. The facility also provides for laser scanning analysis of experimental data. Gene Center Researchers use the facility to conduct pioneering research in the following areas: Damage and Repair of the Nervous System, Neurobiology of Drug Abuse, Molecular Mechanism of Pain, Protein Structure and Function, Molecular Basis of Behavior, Immunology and Development, Nanotechnology and Bio-Organic Chemistry. Our plan is to replace an obsolete ten-year-old confocal microscope with an instrument that meets our research needs. We also plan to purchase a digital transmission electron microscope (TEM) to replace a very old and obsolete analog model so that we may serve the needs of our researchers. The two microscopes will be located in the Digital Bioimaging Core Facility, which will be renovated using institutional funds to accommodate the instruments. We are also requesting RCMI grant support to hire a research assistant with expertise in preparing samples for electron microscopy. This research assistant will be supervised by Dr. Lloyd Williams, the manager of the facility. The proposed improvements will significantly upgrade the facility, while making it possible to perform sophisticated and quantitative experiments and to share research results through the internet in real time. These improvements will make a major impact on the research output of the Gene Center.

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