Optimising myelin repair and restoring neuronal function in the demyelinated brain

优化脱髓鞘大脑中的髓磷脂修复并恢复神经元功能

• 批准号: nhmrc : 1140962
• 负责人: Dr Tobias Merson
• 金额: $ 68.29万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/optimising-myelin-repair-demyelinated-brain/1319344
• 关键词: Optimising; myelin; repair; restoring; neuronal

Multiple sclerosis is a disease of the brain and spinal cord caused by damage to white matter. In healthy brains, a substance in white matter called myelin insulates the axons (cables) of nerve cells, which speeds up electrical conduction. In MS, myelin is destroyed which impairs conduction and can lead to permanent loss of axons and nerve cells. To prevent this, we will test whether increasing electrical activity in nerve cells helps restore myelin by activating myelin-forming stem cells.

多发性硬化症是一种由白色物质损伤引起的脑和脊髓疾病。在健康的大脑中，白色物质中的一种物质称为髓磷脂，它使神经细胞的轴突（电缆）绝缘，从而加速电传导。在MS中，髓鞘被破坏，这损害了传导，并可能导致轴突和神经细胞的永久性丧失。为了防止这种情况，我们将测试神经细胞中增加的电活动是否有助于通过激活髓鞘形成干细胞来恢复髓鞘。