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Cellular responses to oligodendrcyte apoptosis: modeling the early pathogenesis of Multiple Sclerosis

Cellular responses to oligodendrcyte apoptosis: modeling the early pathogenesis of Multiple Sclerosis
细胞对少突胶质细胞凋亡的反应:模拟多发性硬化症的早期发病机制
批准号:
nhmrc : 628749
负责人:
Dr Tobias Merson
金额:
$30.68万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

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中文摘要
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英文摘要
In Multiple Sclerosis, oligodendrocytes (the myelin-producing cells of the brain) are damaged and myelin is lost. This process results in damage to nerve cells. We have generated a model of oligodendrocyte death that results in nerve cell damage. We will use this model to understand how nerve cells become damaged when oligodendrocytes die and whether the brain can make new oligodendrocytes to protect nerve cells from further damage.
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Optimising myelin repair and restoring neuronal function in the demyelinated brain
  • 批准号:
    nhmrc : 1140962
  • 项目类别:
    Project Grants
  • 资助金额:
    $68.29万
  • 财政年份:
    2018
  • 负责人:
    Dr Tobias Merson
  • 依托单位:
Optimising myelin repair and restoring neuronal function in the demyelinated brain
  • 批准号:
    nhmrc : GNT1140962
  • 项目类别:
    Project Grants
  • 资助金额:
    $100.99万
  • 财政年份:
    2018
  • 负责人:
    Dr Tobias Merson
  • 依托单位:
Assessing the mechanisms and dynamics of myelination in the brain
  • 批准号:
    FT150100207
  • 项目类别:
    ARC Future Fellowships
  • 资助金额:
    $47.74万
  • 财政年份:
    2016
  • 负责人:
    Dr Tobias Merson
  • 依托单位:
Investigating mechanisms of axonal pathology following oligodendrocyte apoptosis: avenues for neuroprotection in early MS
  • 批准号:
    nhmrc : 1066199
  • 项目类别:
    Project Grants
  • 资助金额:
    $45.22万
  • 财政年份:
    2014
  • 负责人:
    Dr Tobias Merson
  • 依托单位:
海外基金